Misexpression of testicular microRNA in sterile Xenopus hybrids points to tetrapod-specific microRNAs associated with male fertility [0.03%]
无受精能力的非洲爪蟾杂交种中睾丸特异性微小核糖核酸的错表达揭示了与雄性生育力相关的四足动物特有的微小核糖核酸
Mercedita J Madison-Villar,Pawel Michalak
Mercedita J Madison-Villar
Spermatogenesis is one of the most complex biological processes undergone by any organism, making it susceptible to perturbations that result in male sterility. Research has demonstrated that mutant phenotypes can be obtained from the disru...
Two polymorphic residues account for the differences in DNA binding and transcriptional activation by NF-κB proteins encoded by naturally occurring alleles in Nematostella vectensis [0.03%]
两个多态性残基解释了Nematostella vectensis中天然存在的等位基因编码的NF-κB蛋白在DNA结合和转录激活方面的差异
Francis S Wolenski,Sushil Chandani,Derek J Stefanik et al.
Francis S Wolenski et al.
The NF-κB family of transcription factors is activated in response to many environmental and biological stresses, and plays a key role in innate immunity across a broad evolutionary expanse of animals. A simple NF-κB pathway is present in...
Is there a twelfth protein-coding gene in the genome of influenza A? A selection-based approach to the detection of overlapping genes in closely related sequences [0.03%]
流感病毒基因组中存在第12个编码蛋白的基因吗？一种用于检测紧密相关序列中的重叠基因的选择性方法
Niv Sabath,Jeffrey S Morris,Dan Graur
Niv Sabath
Protein-coding genes often contain long overlapping open-reading frames (ORFs), which may or may not be functional. Current methods that utilize the signature of purifying selection to detect functional overlapping genes are limited to the ...
A revised timeline for the origin of Plasmodium falciparum as a human pathogen [0.03%]
疟原虫作为人类病原体起源时间的一个修订版timeline
Jason M Baron,John M Higgins,Walter H Dzik
Jason M Baron
While Plasmodium falciparum is known to have had a strong effect on human evolution, the time period when P. falciparum first infected ancestors of modern humans has remained uncertain. Recent advances demonstrated that P. falciparum evolve...
An expansion of age constraints for microbial clades that lack a conventional fossil record using phylogenomic dating [0.03%]
基于系统基因组的年代地层学扩大了缺乏传统化石记录的微生物类群的地质时代约束上限
Carrine E Blank
Carrine E Blank
Most microbial taxa lack a conventional microfossil or biomarker record, and so we currently have little information regarding how old most microbial clades and their associated traits are. Building on the previously published oxygen age co...
Evaluating the impact of post-mortem damage in ancient DNA: a theoretical approach [0.03%]
古代DNA死后损伤影响的理论评估方法
Martyna Molak,Simon Y W Ho
Martyna Molak
The growth of ancient DNA research has offered exceptional opportunities and raised great expectations, but has also presented some considerable challenges. One of the ongoing issues is the impact of post-mortem damage in DNA molecules. Nuc...
Genome-wide comparative analysis of pogo-like transposable elements in different Fusarium species [0.03%]
臂菌亚属中pogo类转座子的全基因组比较分析
Marie Dufresne,Olivier Lespinet,Marie-Josée Daboussi et al.
Marie Dufresne et al.
The recent availability of genome sequences of four different Fusarium species offers the opportunity to perform extensive comparative analyses, in particular of repeated sequences. In a recent work, the overall content of such sequences in...
Comparative Study
Journal of molecular evolution. 2011 Oct;73(3-4):230-43. DOI:10.1007/s00239-011-9472-1 2011
Self-replication reactions dependent on tertiary interaction motifs in an RNA ligase ribozyme [0.03%]
依赖三级相互作用基元的RNA连接酶核酶的自我复制反应
Rei Ohmori,Hirohide Saito,Yoshiya Ikawa et al.
Rei Ohmori et al.
RNA can function both as an informational molecule and as a catalyst in living organisms. This duality is the premise of the RNA world hypothesis. However, one flaw in the hypothesis that RNA was the most essential molecule in primitive lif...
Unassigned codons, nonsense suppression, and anticodon modifications in the evolution of the genetic code [0.03%]
未赋予功能的密码子、终止密码子的抑制以及反密码子修饰在遗传密码进化中的作用
Peter T S van der Gulik,Wouter D Hoff
Peter T S van der Gulik
The origin of the genetic code is a central open problem regarding the early evolution of life. Here, we consider two undeveloped but important aspects of possible scenarios for the evolutionary pathway of the translation machinery: the rol...
Evolution of the TOR pathway [0.03%]
TOR途径的进化
Teunis J P van Dam,Fried J T Zwartkruis,Johannes L Bos et al.
Teunis J P van Dam et al.
The TOR kinase is a major regulator of growth in eukaryotes. Many components of the TOR pathway are implicated in cancer and metabolic diseases in humans. Analysis of the evolution of TOR and its pathway may provide fundamental insight into...