Effects of Chemical Fixatives on Kinetic Measurements of Biomolecular Interaction on Cell Membrane [0.03%]
化学固定剂对细胞膜上生物分子相互作用的动态测量的影响
Tianbao Dong,Shengyang Wan,Yanhui Wang et al.
Tianbao Dong et al.
Understanding the interaction between ligands and membrane proteins is important for drug design and optimization. Although investigation using live cells is desirable, it is not feasible in some circumstances and cell fixation is performed...
Lidocaine Inhibits Rat Prostate Cancer Cell Invasiveness and Voltage-Gated Sodium Channel Expression in Plasma Membrane [0.03%]
利多卡因抑制雄性大鼠前列腺癌细胞的侵略性以及质膜中电压门控钠通道的表达
Nahit Rizaner,Scott P Fraser,Ilknur Bugan Gul et al.
Nahit Rizaner et al.
There is increasing evidence, mostly from breast cancer, that use of local anaesthetics during surgery can inhibit disease recurrence by suppressing the motility of the cancer cells dependent on inherent voltage-gated sodium channels (VGSCs...
Identification of Prognostic and Immune Characteristics of Two Lung Adenocarcinoma Subtypes Based on TRPV Channel Family Genes [0.03%]
基于瞬时受体电位V家族基因的两种肺腺癌亚型预后和免疫特征的识别
Jianhua Jiang,Pengchao Zheng,Lei Li
Jianhua Jiang
Lung adenocarcinoma (LUAD) is one of the deadliest malignant tumors worldwide. Transient receptor potential vanilloid (TRPV) channels take pivotal parts in many cancers, but their impact on LUAD remains unexplored. In this study, LUAD sampl...
Exploration of the Catalytic Cycle Dynamics of Vigna Radiata H+-Translocating Pyrophosphatases Through Hydrogen-Deuterium Exchange Mass Spectrometry [0.03%]
氢氘交换质谱技术揭示光盘病毒H+-驱动的焦磷酸酶催化循环动力学
Li-Kun Huang,Yi-Cyuan Huang,Pin-Chuan Chen et al.
Li-Kun Huang et al.
Vigna radiata H+-translocating pyrophosphatases (VrH+-PPases, EC 3.6.1.1) are present in various endomembranes of plants, bacteria, archaea, and certain protozoa. They transport H+ into the lumen by hydrolyzing pyrophosphate, which is a by-...
Alexey S Ladokhin
Alexey S Ladokhin
Host Lipid Manipulation by Intracellular Bacteria: Moonlighting for Immune Evasion [0.03%]
胞内细菌操纵宿主脂质合成以逃避免疫攻击
Naveen Challagundla,Deepti Phadnis,Aakriti Gupta et al.
Naveen Challagundla et al.
Lipids are complex organic molecules that fulfill energy demands and sometimes act as signaling molecules. They are mostly found in membranes, thus playing an important role in membrane trafficking and protecting the cell from external dang...
Aurelia R Honerkamp-Smith
Aurelia R Honerkamp-Smith
Published Erratum
The Journal of membrane biology. 2023 Dec;256(4-6):341. DOI:10.1007/s00232-023-00297-7 2023
Role of Hydrophobic Amino-Acid Side-Chains in the Narrow Selectivity Filter of the CFTR Chloride Channel Pore in Conductance and Selectivity [0.03%]
CFTR氯通道孔道中疏水氨基酸侧链在传导性和选择性中的窄选择滤器作用
Paul Linsdell
Paul Linsdell
Cystic fibrosis is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel. Structural analysis of CFTR has identified a narrow, hydrophobic region close to the extracellular end of the open chann...
Aurelia R Honerkamp-Smith
Aurelia R Honerkamp-Smith
Cationic Proteins Rich in Lysine Residue Trigger Formation of Non-bilayer Lipid Phases in Model and Biological Membranes: Biophysical Methods of Study [0.03%]
富含赖氨酸残基的阳离子蛋白触发模型和生物膜中非双层脂质相形成的分子机制研究：生物物理方法研究
Meiyi Li,Edward S Gasanoff
Meiyi Li
Cationic membrane-active toxins are the most abundant group of proteins in the venom of snakes and insects. Cationic proteins such as cobra venom cytotoxin and bee venom melittin are known for their pharmacological reactions including antic...