Deciphering the Influence of Side Chains of Short Cationic Hydrophobic Peptides on Macroscopic and Molecular Properties of Mixed Lipid Bilayers [0.03%]
短阳离子疏水肽侧链对混合脂质双层宏观性质和分子性质影响的研究
Lea Pašalić,Andreja Jakas,Ana Čikoš et al.
Lea Pašalić et al.
Cell-penetrating peptides (CPPs) are increasingly used for delivering cargo into cells, but the mechanisms of their membrane crossing remain poorly understood, even for shorter cationic hydrophobic peptides. This study explores how cationic...
Mechanistic Insights into Human Defensin Antimicrobial Activity from Membrane Simulations [0.03%]
基于膜模拟的人类防御素抗菌活性机制研究
Anna K Manukyan
Anna K Manukyan
Defensins function as critical effectors of innate immunity, displaying broad-spectrum antimicrobial activity against bacteria, fungi, and viruses. While experimental studies have extensively characterized these peptides, the molecular mech...
Rapid Single-cell Measurement of Transient Transmembrane Water Flow under Osmotic Gradient [0.03%]
一种快速测量渗透压梯度下单细胞膜瞬态水平衡流动的方法
Hong Jiang,Jinnawat Jongkhumkrong,Y J Chao et al.
Hong Jiang et al.
Aquaporins (AQPs) are critical for transmembrane water transport in response to osmotic gradients, but their gating and regulatory mechanisms remain poorly understood. A central challenge is the lack of methods to measure water flow across ...
Analysis of the Effect of the Magnetic Field on Water Flux Through TIP3;1 Aquaporins Using Molecular Dynamics in GROMACS [0.03%]
利用GROMACS软件中分子动力学模拟磁场对TIP3;1水通道蛋白的水通量影响分析
Diego Fernando Nieto-Giraldo,José Mauricio Rodas Rodríguez,Javier Torres-Osorio
Diego Fernando Nieto-Giraldo
Magnetobiology studies the effects of magnetic fields on biological systems. In this context, the Magnetobiology Research Group at the University of Caldas has hypothesized that magnetic treatment may influence water flow through cell membr...
Membrane Remodeling Activity of Dengue Virus NS4A and NS1 Proteins: A Computational Perspective [0.03%]
登革病毒NS4A和NS1蛋白的膜重塑作用：计算视角
Dwaipayan Chaudhuri,Kalyan Giri
Dwaipayan Chaudhuri
Dengue virus (DENV) non-structural protein NS4A and NS1 are crucial for viral replication and have the ability to cause extensive remodeling of the host cell membrane. Here, a computational strategy has been used to study the structural and...
Oxysterol Induced Fluid-Fluid Phase Separation in Saturated Phosphatidylcholine Membranes: Influence of Lipid Chain Length [0.03%]
氧化固醇诱导的饱和卵磷脂膜中的液液相分离：脂质链长的影响
P K Shabeeb,Sreeja Sasidharan,S Madhukar et al.
P K Shabeeb et al.
We have recently reported the observation of closed-loop fluid-fluid immiscibility in 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) lipid membranes containing either 25-hydroxycholesterol (25HCH) or 27-hydroxycholesterol (27HCH) (Kamal...
Targeting hORAI1-Mediated Calcium Influx in Triple-Negative Breast Cancer: A Computational Drug Discovery Approach [0.03%]
计算药物发现方法在三阴性乳腺癌中靶向hORAI1介导的钙离子流入方面的研究
Sangavi Pandi,Hemavathy Nagarajan,Sneha Subramaniyan et al.
Sangavi Pandi et al.
Store-operated calcium entry (SOCE) is a crucial pathway that aids in restoring depleted calcium levels in the endoplasmic reticulum (ER), consequently regulating cellular calcium homeostasis. When calcium stores are low, two key proteins a...
Na+ Uptake Triggered in Adrenal Chromaffin Cells by a 5-ns Electric Pulse is Facilitated by Ca2+ Influx Via an L-Type-Like Ca2+ Channel Independent of Changes in Membrane Potential [0.03%]
由5 ns电脉冲引发的肾上腺嗜铬细胞中Na+内流由类似L型的Ca2+通道介导，且与膜电位的变化无关
Lisha Yang,Josette Zaklit,Thomas W Gould et al.
Lisha Yang et al.
Whole-cell voltage patch clamp studies have shown that in bovine adrenal chromaffin cells held at -70 mV, a single 5-ns, 5 MV/m pulse activates a membrane conductance carried partially by Na+ through TRPC4/5 channels and the sodium leak cha...
Peptide-Assisted Membrane Permeabilization: Effects of Waveform Polarity, Inter-Monopulse Interval, and Surface Charge in Red Blood Cells and Planar Lipid Bilayers [0.03%]
肽辅助的膜渗透性：红细胞和平面脂质双层中的波形极性、单脉冲间隔和表面电荷的影响
José Alexander Alvarez-Bustamante,Diego Ortiz-Mejía,Victor V Lemeshko
José Alexander Alvarez-Bustamante
Permeabilization of biomembranes by polycationic peptides is known to depend on the membrane potential, although the exact mechanism of this process is not yet completely defined, to be effectively controlled. We quantified peptide-assisted...