Residues of TRPM8 at the Lipid-Water-Interface have Coevolved with Cholesterol Interaction and are Relevant for Diverse Health Disorders [0.03%]
TRPM8通道脂水界面残基与胆固醇相互作用共进化并与多种健康疾病相关
Deep Shikha,Ritesh Dalai,Shamit Kumar et al.
Deep Shikha et al.
TRPM8 is a non-selective cation channel that is expressed in several tissues and cells and also has a unique property to be activated by low-temperature. In this work, we have analyzed the conservation of amino acids that are present in the...
Feasibility Study for the Use of Gene Electrotransfer and Cell Electrofusion as a Single-Step Technique for the Generation of Activated Cancer Cell Vaccines [0.03%]
基因电转染和细胞电融合技术一步法产生激活型癌症疫苗的可行性研究
Marko Ušaj,Mojca Pavlin,Maša Kandušer
Marko Ušaj
Cell-based therapies hold great potential for cancer immunotherapy. This approach is based on manipulation of dendritic cells to activate immune system against specific cancer antigens. For the development of an effective cell vaccine platf...
A Model for Reversible Electroporation to Deliver Drugs into Diseased Tissues [0.03%]
一种可逆电穿孔向病变组织递送药物的模型
Nilay Mondal,D C Dalal
Nilay Mondal
Drug delivery through electroporation could be highly beneficial for the treatment of different types of diseased tissues within the human body. In this work, a mathematical model of reversible tissue electroporation is presented for inject...
Correlation Between Antimicrobial Structural Classes and Membrane Partitioning: Role of Emerging Lipid Packing Defects [0.03%]
抗菌分子结构类型与生物膜亲和力之间的关联性：脂质堆积缺陷发挥的作用
S V Sankaran,Roni Saiba,Samapan Sikdar et al.
S V Sankaran et al.
In this study, a combination of bioinformatics and molecular dynamics simulations is employed to investigate the partitioning behavior of different classes of antimicrobial peptides (AMPs) into model membranes. The main objective is to iden...
A Critical Review of Short Antimicrobial Peptides from Scorpion Venoms, Their Physicochemical Attributes, and Potential for the Development of New Drugs [0.03%]
用于新药开发的蝎毒短抗菌肽及其理化性质批判性综述
Pedro Alejandro Fong-Coronado,Verónica Ramirez,Verónica Quintero-Hernández et al.
Pedro Alejandro Fong-Coronado et al.
Scorpion venoms have proven to be excellent sources of antimicrobial agents. However, although many of them have been functionally characterized, they remain underutilized as pharmacological agents, despite their evident therapeutic potenti...
Sperm-Specific CatSper is Not Conserved in All Vertebrates and May Not be the Only Progesterone-Responsive Ion Channel Present in Sperm [0.03%]
精子特异性CatSper通道并未在所有脊椎动物中保守且可能不是唯一响应孕酮的精子离子通道
Nishant Kumar Dubey,Vikash Kumar,Chandan Goswami
Nishant Kumar Dubey
Progesterone (P4) acts as a key conserved signalling molecule in vertebrate reproduction. P4 is especially important for mature sperm physiology and subsequent reproductive success. "CatSpermasome", a multi-unit molecular complex, has been ...
N-Glycosylation Deficiency in Transgene α7 nAChR and RIC3 Expressing CHO Cells Without NACHO [0.03%]
无烟碱乙酰胆碱受体通道的α7尼古丁乙酰胆碱受体和RIC3转基因表达缺陷的研究-中国仓鼠卵巢细胞模型中的N-连接糖基化缺陷
Sabrina Brockmöller,Lara Maria Molitor,Thomas Seeger et al.
Sabrina Brockmöller et al.
The human neuronal nicotinic acetylcholine receptor α7 (nAChR) is an important target implicated in diseases like Alzheimer's or Parkinson's, as well as a validated target for drug discovery. For α7 nAChR model systems, correct folding an...
Aggregation Behavior of Amyloid Beta Peptide Depends Upon the Membrane Lipid Composition [0.03%]
淀粉样β肽的聚集行为依赖于膜脂质组成
Lipika Mirdha
Lipika Mirdha
Protein aggregation plays a crucial role in the development of several neurodegenerative diseases. It is important to understand the aggregation process for the detection of the onset of these diseases. Alzheimer's Disease (AD) is one of th...
Abundance of the Membrane Proteome in Yeast Cells Lacking Spc1, a Non-catalytic Subunit of the Signal Peptidase Complex [0.03%]
缺乏信号肽酶复合物非催化亚基Spc1的酵母细胞中的膜蛋白组丰度
Chewon Yim,Yeonji Chung,Sungjoon Son et al.
Chewon Yim et al.
The signal peptidase complex (SPC) mediates processing of signal peptides of secretory precursors. But, recent studies show that the eukaryotic SPC also cleaves internal transmembrane segments of some membrane proteins, and its non-catalyti...
Beyond Hormones: Investigating the Impact of Progesterone Receptor Membrane Component 1 in Lung Adenocarcinoma [0.03%]
超越激素：探究肺腺癌中黄体酮受体膜组分1的影响
Solaipriya Solairaja,Sivaramakrishnan Venkatabalasubramanian
Solaipriya Solairaja
Progesterone Receptor Membrane Component 1 (PGRMC1) is a candidate oncogene with a prominent involvement in the pathogenesis of diverse cancers (ovarian, thyroid, breast, colon, head, and neck). Our study ascertains the ability of PGRMC1 to...