Behor Eleazar Cohen
Behor Eleazar Cohen
Cell swelling is known to be involved in various stages of the growth of plant cells and microorganisms but in mammalian cells how crucial a swollen state is for determining the fate of the cellular proliferation remains unclear. Recent evi...
Sphingomyelin Inhibits Hydrolytic Activity of Heterodimeric PLA2 in Model Myelin Membranes: Pharmacological Relevance [0.03%]
鞘磷脂抑制模型髓鞘膜中异二聚体PLA2的水解活性：药理学意义
Anwaar S Chaudary,Yanglin Guo,Yuri N Utkin et al.
Anwaar S Chaudary et al.
In this work, the heterodimeric phospholipase A2, HDP-2, from viper venom was investigated for its hydrolytic activity in model myelin membranes as well as for its effects on intermembrane exchange of phospholipids (studied by phosphorescen...
Postsynaptic Density Proteins and Their Role in the Trafficking of Group I Metabotropic Glutamate Receptors [0.03%]
postsynaptic density蛋白及其在I组代谢型谷氨酸受体转运中的作用
K Aruna,Subhajit Pal,Ankita Khanna et al.
K Aruna et al.
Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system that regulates multiple different forms of synaptic plasticity, including learning and memory. Glutamate transduces its signal by activating ionotrop...
Yan Zhang,Jiawen Wu,Yuxian Zheng et al.
Yan Zhang et al.
Ion channels are integral components of the nervous system, playing a pivotal role in shaping membrane potential, neuronal excitability, synaptic transmission and plasticity. Dysfunction in these channels, such as improper expression or loc...
Enhancing Anti-Cancer Immune Response by Acidosis-Sensitive Nanobody Display [0.03%]
一种酸敏纳米抗体展示技术可增强抗癌免疫应答
Leah E Knepper,Emily T Ankrom,Damien Thévenin
Leah E Knepper
One of the main challenges with many cancer immunotherapies is that biomarkers are needed for targeting. These biomarkers are often associated with tumors but are not specific to a particular tumor and can lead to damage in healthy tissues,...
Early Events in β2AR Dimer Dynamics Mediated by Activation-Related Microswitches [0.03%]
β2肾上腺素能受体二聚体动力学的早期事件由激活相关的微开关介导
Aneesh Kotipalli,Shruti Koulgi,Vinod Jani et al.
Aneesh Kotipalli et al.
G-Protein-Coupled Receptors (GPCRs) make up around 3-4% of the human genome and are the targets of one-third of FDA-approved drugs. GPCRs typically exist as monomers but also aggregate to form higher-order oligomers, including dimers. β2AR...
Evolution of Bioelectric Membrane Potentials: Implications in Cancer Pathogenesis and Therapeutic Strategies [0.03%]
生物电膜电位的演变：对癌症发生机制及治疗策略的意义
Anju Shrivastava,Amit Kumar,Lalit Mohan Aggarwal et al.
Anju Shrivastava et al.
Electrophysiology typically deals with the electrical properties of excitable cells like neurons and muscles. However, all other cells (non-excitable) also possess bioelectric membrane potentials for intracellular and extracellular communic...
Residues of TRPM8 at the Lipid-Water-Interface have Coevolved with Cholesterol Interaction and are Relevant for Diverse Health Disorders [0.03%]
TRPM8通道脂水界面残基与胆固醇相互作用共进化并与多种健康疾病相关
Deep Shikha,Ritesh Dalai,Shamit Kumar et al.
Deep Shikha et al.
TRPM8 is a non-selective cation channel that is expressed in several tissues and cells and also has a unique property to be activated by low-temperature. In this work, we have analyzed the conservation of amino acids that are present in the...
Feasibility Study for the Use of Gene Electrotransfer and Cell Electrofusion as a Single-Step Technique for the Generation of Activated Cancer Cell Vaccines [0.03%]
基因电转染和细胞电融合技术一步法产生激活型癌症疫苗的可行性研究
Marko Ušaj,Mojca Pavlin,Maša Kandušer
Marko Ušaj
Cell-based therapies hold great potential for cancer immunotherapy. This approach is based on manipulation of dendritic cells to activate immune system against specific cancer antigens. For the development of an effective cell vaccine platf...
A Model for Reversible Electroporation to Deliver Drugs into Diseased Tissues [0.03%]
一种可逆电穿孔向病变组织递送药物的模型
Nilay Mondal,D C Dalal
Nilay Mondal
Drug delivery through electroporation could be highly beneficial for the treatment of different types of diseased tissues within the human body. In this work, a mathematical model of reversible tissue electroporation is presented for inject...