Rajan Lamichhane
Rajan Lamichhane
Schisandrin B Improves Mitochondrial Function and Inhibits HT22 Cell Apoptosis by Regulating Sirt3 Protein [0.03%]
五味子乙素通过调节Sirt3蛋白改善线粒体功能及抑制HT22细胞凋亡作用机制研究
Fei Hu,Songlin Tong,Hongming Xu
Fei Hu
Neurological diseases refer to pathological changes that occur in the brain, spinal cord, and peripheral nerves. Their etiologies are complex, treatment outcomes are poor, and prognoses are unfavorable. Therefore, how to improve the treatme...
Gamma-Aminobutyric Acid Action on Membrane and Electrical Properties of Synaptosomes and Model Lipid Bilayers [0.03%]
γ-氨基丁酸对突触囊泡和模型脂质双分子层膜及电性质的作用
Virjinia Doltchinkova,Victoria Vitkova,Ognyan Petkov et al.
Virjinia Doltchinkova et al.
Dysfunction of the main inhibitory neurotransmitter gamma-aminobutyric acid (GABA) is the underlying reason behind many neurological disorders including Alzheimer's and Huntington's diseases, autism spectrum disorders, anxiety, depression, ...
Computational Insights on the Assembly of the Dengue Virus Membrane-Capsid-RNA Complex [0.03%]
登革病毒包膜-衣壳-RNA复合物组装的计算研究
Dwaipayan Chaudhuri,Satyabrata Majumder,Joyeeta Datta et al.
Dwaipayan Chaudhuri et al.
Dengue virus, an arbovirus from the genus Flavivirus in the family Flaviviridae, forms a nucleocapsid structure through interactions between its genome and multiple copies of the capsid protein. Experimental studies have confirmed the inter...
Dengue Virus Fusion Peptide Promotes Hemifusion Formation by Disordering the Interfacial Region of the Membrane [0.03%]
登革病毒融合肽通过干扰膜界面区域有序性来促进半融合体的形成
Smruti Mishra,Hirak Chakraborty
Smruti Mishra
Membrane fusion is the first step in the infection process of the enveloped viruses. Enveloped viruses fuse either at the cell surface or enter the cell through endocytosis and transfer their internal genetic materials by fusing with the en...
Pharmacodynamic characterization and evaluation of oxidative stress effects of digitoxigenin derivatives on HeLa cells [0.03%]
digitoxigenin 衍生物的药理学特征及对氧化应激影响海拉细胞的作用评价
Jessica M M Valadares,Pedro Azalim-Neto,Xiaofan Liu et al.
Jessica M M Valadares et al.
Cancer is a leading cause of death worldwide and its treatment is hampered by the lack of specificity and side effects of current drugs. Cardiotonic steroids (CTS) interact with Na+/K+-ATPase (NKA) and induce antineoplastic effects, but the...
Karen Stephania González-Ponce,Samuel Celaya-Herrera,María Fernanda Mendoza-Acosta et al.
Karen Stephania González-Ponce et al.
The Cell-Free Protein Synthesis (CFPS) is an innovative technique used to produce various proteins. It has several advantages, including short expression times, no strain engineering is required, and toxic proteins such as membrane proteins...
Remya Satheesan,Asuma Janeena,Kozhinjampara R Mahendran
Remya Satheesan
Protein nanopores are emerging as versatile single-molecule sensors with broad applications in DNA and protein sequencing. However, their narrow size restricts the range of detectable analytes, necessitating the development of advanced nano...
Interaction of an Oomycete Nep1-like Cytolysin with Natural and Plant Cell-Mimicking Membranes [0.03%]
霜霉菌Nep1样细胞溶解毒蛋白与天然及植物仿生膜的相互作用
Tina Snoj,Tjaša Lukan,Kristina Gruden et al.
Tina Snoj et al.
Plants are attacked by various pathogens that secrete a variety of effectors to damage host cells and facilitate infection. One of the largest and so far understudied microbial protein families of effectors is necrosis- and ethylene-inducin...
Effect of Triterpenoids Betulin and Betulinic Acid on Pulmonary Surfactant Membranes [0.03%]
桦皮素和桦皮酸对肺表面活性剂膜的影响
Cisem Altunayar-Unsalan,Ozan Unsalan
Cisem Altunayar-Unsalan
The purpose of this work is to examine how triterpenoids betulin (BE) and betulinic acid (BA) affect the thermotropic phase behaviour and bilayer packing in pulmonary surfactant membranes. Therefore, the interaction of these triterpenoids w...