Remya Satheesan,Asuma Janeena,Kozhinjampara R Mahendran
Remya Satheesan
Protein nanopores are emerging as versatile single-molecule sensors with broad applications in DNA and protein sequencing. However, their narrow size restricts the range of detectable analytes, necessitating the development of advanced nano...
Interaction of an Oomycete Nep1-like Cytolysin with Natural and Plant Cell-Mimicking Membranes [0.03%]
霜霉菌Nep1样细胞溶解毒蛋白与天然及植物仿生膜的相互作用
Tina Snoj,Tjaša Lukan,Kristina Gruden et al.
Tina Snoj et al.
Plants are attacked by various pathogens that secrete a variety of effectors to damage host cells and facilitate infection. One of the largest and so far understudied microbial protein families of effectors is necrosis- and ethylene-inducin...
Effect of Triterpenoids Betulin and Betulinic Acid on Pulmonary Surfactant Membranes [0.03%]
桦皮素和桦皮酸对肺表面活性剂膜的影响
Cisem Altunayar-Unsalan,Ozan Unsalan
Cisem Altunayar-Unsalan
The purpose of this work is to examine how triterpenoids betulin (BE) and betulinic acid (BA) affect the thermotropic phase behaviour and bilayer packing in pulmonary surfactant membranes. Therefore, the interaction of these triterpenoids w...
Behor Eleazar Cohen
Behor Eleazar Cohen
Cell swelling is known to be involved in various stages of the growth of plant cells and microorganisms but in mammalian cells how crucial a swollen state is for determining the fate of the cellular proliferation remains unclear. Recent evi...
Sphingomyelin Inhibits Hydrolytic Activity of Heterodimeric PLA2 in Model Myelin Membranes: Pharmacological Relevance [0.03%]
鞘磷脂抑制模型髓鞘膜中异二聚体PLA2的水解活性：药理学意义
Anwaar S Chaudary,Yanglin Guo,Yuri N Utkin et al.
Anwaar S Chaudary et al.
In this work, the heterodimeric phospholipase A2, HDP-2, from viper venom was investigated for its hydrolytic activity in model myelin membranes as well as for its effects on intermembrane exchange of phospholipids (studied by phosphorescen...
Postsynaptic Density Proteins and Their Role in the Trafficking of Group I Metabotropic Glutamate Receptors [0.03%]
postsynaptic density蛋白及其在I组代谢型谷氨酸受体转运中的作用
K Aruna,Subhajit Pal,Ankita Khanna et al.
K Aruna et al.
Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system that regulates multiple different forms of synaptic plasticity, including learning and memory. Glutamate transduces its signal by activating ionotrop...
Yan Zhang,Jiawen Wu,Yuxian Zheng et al.
Yan Zhang et al.
Ion channels are integral components of the nervous system, playing a pivotal role in shaping membrane potential, neuronal excitability, synaptic transmission and plasticity. Dysfunction in these channels, such as improper expression or loc...
Enhancing Anti-Cancer Immune Response by Acidosis-Sensitive Nanobody Display [0.03%]
一种酸敏纳米抗体展示技术可增强抗癌免疫应答
Leah E Knepper,Emily T Ankrom,Damien Thévenin
Leah E Knepper
One of the main challenges with many cancer immunotherapies is that biomarkers are needed for targeting. These biomarkers are often associated with tumors but are not specific to a particular tumor and can lead to damage in healthy tissues,...
Early Events in β2AR Dimer Dynamics Mediated by Activation-Related Microswitches [0.03%]
β2肾上腺素能受体二聚体动力学的早期事件由激活相关的微开关介导
Aneesh Kotipalli,Shruti Koulgi,Vinod Jani et al.
Aneesh Kotipalli et al.
G-Protein-Coupled Receptors (GPCRs) make up around 3-4% of the human genome and are the targets of one-third of FDA-approved drugs. GPCRs typically exist as monomers but also aggregate to form higher-order oligomers, including dimers. β2AR...
Evolution of Bioelectric Membrane Potentials: Implications in Cancer Pathogenesis and Therapeutic Strategies [0.03%]
生物电膜电位的演变：对癌症发生机制及治疗策略的意义
Anju Shrivastava,Amit Kumar,Lalit Mohan Aggarwal et al.
Anju Shrivastava et al.
Electrophysiology typically deals with the electrical properties of excitable cells like neurons and muscles. However, all other cells (non-excitable) also possess bioelectric membrane potentials for intracellular and extracellular communic...