Passage of the Channel-Forming Agent Nystatin Through Ergosterol-Containing Lipid Membranes [0.03%]
含麦角固醇的脂质膜上的通道形成剂奈斯替丁的透过性研究
Megi Tinev,Luka Kristanc,Gregor Gomišček et al.
Megi Tinev et al.
The passage of nystatin through the ergosterol-containing phospholipid bilayer was studied on monovesicular and multivesicular giant unilamellar vesicles (GUVs and MVVs). Phase-contrast optical microscopy was used to examine vesicles compos...
Mycobacterium tuberculosis TtfA is a Highly Stable Membrane-Anchored DNA-Binding Protein [0.03%]
稳定锚定于膜的DNA结合蛋白米氏体TtfA
Saksham Jain,Akanksha Gajanan Patil,Saniya Patil et al.
Saksham Jain et al.
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is a deadly intracellular pathogen, with a persistent infectivity and high morbidity rate. Mtb has successfully evaded drugs and modern antibiotics, while also deve...
Harsha Bajaj
Harsha Bajaj
Introduction to Special Issue on Role of Membranes in the Pore-Formation Mechanism of Pore-Forming Proteins and Toxins [0.03%]
图论在蛋白质和毒蛋白穿孔机制中的作用研究专题介绍
Kausik Chattopadhyay
Kausik Chattopadhyay
Resurrection of the Helical Hairpin Hypothesis for Understanding Coronavirus Fusion [0.03%]
冠状病毒融合的螺旋发夹假说重获新生
Sahil Lall,M Vijayasarathy,N V Joshi et al.
Sahil Lall et al.
Coronaviruses use the spike protein (spike) to bind to target cells, and fuse the viral envelope with a host lipid membrane. Spike is a large trimeric surface glycoprotein, anchored to the viral membrane (envelope) by a single membrane-span...
Oxysterols Outcompete Cholesterol Binding to the Membrane-Inserted Cytolysin A Pore Complex [0.03%]
氧化固醇通过细胞毒蛋白A通道与胆固醇竞争膜结合
Samlesh Choudhury,Bharath Desikan,K Ganapathy Ayappa
Samlesh Choudhury
Pore-forming toxins (PFTs) belong to a class of proteins expressed by bacteria to initiate infections by unregulated pore formation on the plasma membrane of host cells. Although cholesterol is a key sterol motif that promotes toxin activit...
Cholesterol Affects the Pore Formation and the Membrane-Membrane Interaction Induced by an Antimicrobial Peptide, NK-2, in Phospholipid Vesicles [0.03%]
胆固醇影响抗菌肽NK-2诱导的磷脂囊泡中的孔道形成及膜相互作用
Surajit Das,Rajeev Jain,Kalyan Kumar Banerjee et al.
Surajit Das et al.
Antimicrobial peptides are part of the innate immune response and show their antimicrobial activity by forming pores, followed by disintegration of the membrane. Cholesterol in the membrane can affect the pore formation process, as choleste...
Ranjit Bhoi,Tuhina Mitra,Kallam Tejaswi et al.
Ranjit Bhoi et al.
Ion channels play an integral role in the normal functioning of the brain. They regulate neuronal electrical properties like synaptic activity, generation of action potentials, maintenance of resting membrane potential and neuronal plastici...
Pore Formation by Pore Forming Proteins in Lipid Membranes: Structural Insights Through Cryo-EM [0.03%]
脂质膜中穿孔蛋白的成孔作用：通过冷冻电镜获得的结构见解
Arnab Chatterjee,Prasenjit Naskar,Suman Mishra et al.
Arnab Chatterjee et al.
Many pathogenic bacteria utilize their complicated appalling arsenal, bacterial virulence factors, to attack host cells by damaging the host cell membrane and neutralizing host defense mechanisms. Bacterial pore-forming proteins (PFPs) are ...
Cholesterol Concentration in Cell Membranes and its Impact on Receptor-Ligand Interaction: A Computational Study of ATP-Sensitive Potassium Channels and ATP Binding [0.03%]
细胞膜中的胆固醇浓度及其对受体-配体相互作用的影响：ATP敏感性钾通道和ATP结合的计算研究
Cesar Millan-Pacheco,Iris N Serratos,Gerardo J Félix-Martínez et al.
Cesar Millan-Pacheco et al.
This work describes a computer study that looks at how different amounts of cholesterol (0%, 25%, and 50%) in cell membranes change the relationship between ATP and the KATP channel. This could explain why pancreatic beta-cells secrete insu...