Analysis of the Effect of the Magnetic Field on Water Flux Through TIP3;1 Aquaporins Using Molecular Dynamics in GROMACS [0.03%]
利用GROMACS软件中分子动力学模拟磁场对TIP3;1水通道蛋白的水通量影响分析
Diego Fernando Nieto-Giraldo,José Mauricio Rodas Rodríguez,Javier Torres-Osorio
Diego Fernando Nieto-Giraldo
Magnetobiology studies the effects of magnetic fields on biological systems. In this context, the Magnetobiology Research Group at the University of Caldas has hypothesized that magnetic treatment may influence water flow through cell membr...
Membrane Remodeling Activity of Dengue Virus NS4A and NS1 Proteins: A Computational Perspective [0.03%]
登革病毒NS4A和NS1蛋白的膜重塑作用：计算视角
Dwaipayan Chaudhuri,Kalyan Giri
Dwaipayan Chaudhuri
Dengue virus (DENV) non-structural protein NS4A and NS1 are crucial for viral replication and have the ability to cause extensive remodeling of the host cell membrane. Here, a computational strategy has been used to study the structural and...
Oxysterol Induced Fluid-Fluid Phase Separation in Saturated Phosphatidylcholine Membranes: Influence of Lipid Chain Length [0.03%]
氧化固醇诱导的饱和卵磷脂膜中的液液相分离：脂质链长的影响
P K Shabeeb,Sreeja Sasidharan,S Madhukar et al.
P K Shabeeb et al.
We have recently reported the observation of closed-loop fluid-fluid immiscibility in 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) lipid membranes containing either 25-hydroxycholesterol (25HCH) or 27-hydroxycholesterol (27HCH) (Kamal...
Targeting hORAI1-Mediated Calcium Influx in Triple-Negative Breast Cancer: A Computational Drug Discovery Approach [0.03%]
计算药物发现方法在三阴性乳腺癌中靶向hORAI1介导的钙离子流入方面的研究
Sangavi Pandi,Hemavathy Nagarajan,Sneha Subramaniyan et al.
Sangavi Pandi et al.
Store-operated calcium entry (SOCE) is a crucial pathway that aids in restoring depleted calcium levels in the endoplasmic reticulum (ER), consequently regulating cellular calcium homeostasis. When calcium stores are low, two key proteins a...
Na+ Uptake Triggered in Adrenal Chromaffin Cells by a 5-ns Electric Pulse is Facilitated by Ca2+ Influx Via an L-Type-Like Ca2+ Channel Independent of Changes in Membrane Potential [0.03%]
由5 ns电脉冲引发的肾上腺嗜铬细胞中Na+内流由类似L型的Ca2+通道介导，且与膜电位的变化无关
Lisha Yang,Josette Zaklit,Thomas W Gould et al.
Lisha Yang et al.
Whole-cell voltage patch clamp studies have shown that in bovine adrenal chromaffin cells held at -70 mV, a single 5-ns, 5 MV/m pulse activates a membrane conductance carried partially by Na+ through TRPC4/5 channels and the sodium leak cha...
Peptide-Assisted Membrane Permeabilization: Effects of Waveform Polarity, Inter-Monopulse Interval, and Surface Charge in Red Blood Cells and Planar Lipid Bilayers [0.03%]
肽辅助的膜渗透性：红细胞和平面脂质双层中的波形极性、单脉冲间隔和表面电荷的影响
José Alexander Alvarez-Bustamante,Diego Ortiz-Mejía,Victor V Lemeshko
José Alexander Alvarez-Bustamante
Permeabilization of biomembranes by polycationic peptides is known to depend on the membrane potential, although the exact mechanism of this process is not yet completely defined, to be effectively controlled. We quantified peptide-assisted...
Correction: Evolutionary Analysis of the Lysine-Rich N-terminal Cytoplasmic Domains of the Gastric H+, K+-ATPase and the Na+, K+-ATPase [0.03%]
关于胃H+,K+-ATP酶和Na+,K+-ATP酶富含赖氨酸的N-末端胞质结构域进化分析的更正公告
Ronald J Clarke
Ronald J Clarke
Published Erratum
The Journal of membrane biology. 2025 Oct 21. DOI:10.1007/s00232-025-00364-1 2025
Predicting Toxicity of Insect Venom-Derived Antimicrobial Peptides Using MD Simulations: A Comparative Study of Multi-Component and Realistic Mammalian Membrane Models [0.03%]
基于MD模拟的昆虫毒液来源抗菌肽毒性预测及其多组分和哺乳动物膜模型的比较研究
P Chandra Sekar,Ulka Gawde,Chandan Kumar et al.
P Chandra Sekar et al.
Insect venom-derived antimicrobial peptides (AMPs) hold significant therapeutic promise, but their application is constrained by mammalian cell toxicity. Toxicity assays are rapid and high-throughput, but screening large peptide libraries r...
Celebrating 50 Years of Single-Channel Recording with the Patch Clamp [0.03%]
纪念膜片钳技术发明50周年：单通道记录的里程碑
Luigi Catacuzzeno,Fabio Franciolini
Luigi Catacuzzeno
Fifty years ago, Erwin Neher and Bert Sakmann published a Nature paper on their recording of discrete, step-like currents of a few picoamps passing through individual acetylcholine receptor channels of frog muscle fibers. This observation, ...