Electrostatic Interaction as a Key Modulator of Na+,K+-ATPase Function [0.03%]
静电作用作为Na+,K+-ATP酶功能的关键调节因素
Shadreen Fairuz,Zhitong Li,Amy Gorman et al.
Shadreen Fairuz et al.
The Na+,K+-ATPase is an integral membrane protein present in all animal plasma membranes. It uses the energy of ATP hydrolysis to pump 3 Na+ ions per ATP hydrolysed from the cell cytoplasm into the extracellular fluid in exchange for 2 K+ i...
Evolutionary Prevalence of the Electrostatic Switch Mechanism in P-type ATPases [0.03%]
P型ATP酶中静电开关机制的进化普适性
Nikita S Badve,Alyssa V Buda,Jonas A Káral et al.
Nikita S Badve et al.
P-type ATPases are active transporter enzymes that maintain ion electrochemical gradients for functions such as muscle contraction, kidney function, digestion, and nerve signalling. The dysfunction of these ATPases has been linked to severa...
Structure-Function Insights into Anionic and Cationic Undecapeptides: A Combined Modeling and Antibacterial Study [0.03%]
阳离子和阴离子十一肽的结构-功能关系的理论与实验研究
Thang Nguyen Quoc,Hai Bui Thi Phuong,Duc Nguyen Van et al.
Thang Nguyen Quoc et al.
Antimicrobial peptides (AMPs) represent a promising class of alternatives to conventional antibiotics. In this study, we compared the structural and functional properties of three synthetic undecapeptides: the anionic Cn-AMP2 and its N-term...
Fluorescence Lifetime Spectroscopy Reveals Distinct Allosteric Mechanisms of SERCA Inhibitors [0.03%]
荧光寿命谱学揭示出SERCA抑制剂的特异别构机制
Jaroslava Šeflová,Carlos Cruz-Cortés,Seth L Robia et al.
Jaroslava Šeflová et al.
We recently developed a time-correlated single photon counting (TCSPC) spectroscopy approach to investigate the activation mechanisms of the calcium pump SERCA (sarcoplasmic reticulum Ca2+-ATPase). Here, we apply this approach to characteri...
Deciphering Membrane Pore Formation Mechanisms of Plasmodium falciparum Perforin-Like Protein 1 (PfPLP1) [0.03%]
恶性疟原虫裂解素样穿孔蛋白1介导细胞膜裂解的机制研究
Sanket B Patil,Subrata Dasgupta,Prasenjit Bhaumik
Sanket B Patil
Membrane Attack Complex/Perforin (MACPF) domain proteins are β-pore forming toxins (β-PFTs) involved in the pathogenesis of various organisms. Among them, Perforin-like proteins (PLPs), produced by Plasmodium species, play essential roles...
Molecular Partners of Voltage-Gated Calcium Channel β and α2δ Auxiliary Subunits: Roles in Channel Complex Regulation and Beyond [0.03%]
电压门控钙通道β和α2δ辅助亚基的分子伙伴：在通道复合物调节及其他方面的功能
Alejandra Corzo-López,Margarita Leyva-Leyva,Ricardo González-Ramírez et al.
Alejandra Corzo-López et al.
Research on the auxiliary subunits β (CaVβ) and α2δ (CaVα2δ) of voltage-gated calcium channels has gained increasing interest as novel and unexpected functional interactions for these proteins are discovered. Beyond their classic role...
Deciphering the Influence of Side Chains of Short Cationic Hydrophobic Peptides on Macroscopic and Molecular Properties of Mixed Lipid Bilayers [0.03%]
短阳离子疏水肽侧链对混合脂质双层宏观性质和分子性质影响的研究
Lea Pašalić,Andreja Jakas,Ana Čikoš et al.
Lea Pašalić et al.
Cell-penetrating peptides (CPPs) are increasingly used for delivering cargo into cells, but the mechanisms of their membrane crossing remain poorly understood, even for shorter cationic hydrophobic peptides. This study explores how cationic...
Mechanistic Insights into Human Defensin Antimicrobial Activity from Membrane Simulations [0.03%]
基于膜模拟的人类防御素抗菌活性机制研究
Anna K Manukyan
Anna K Manukyan
Defensins function as critical effectors of innate immunity, displaying broad-spectrum antimicrobial activity against bacteria, fungi, and viruses. While experimental studies have extensively characterized these peptides, the molecular mech...
Rapid Single-cell Measurement of Transient Transmembrane Water Flow under Osmotic Gradient [0.03%]
一种快速测量渗透压梯度下单细胞膜瞬态水平衡流动的方法
Hong Jiang,Jinnawat Jongkhumkrong,Y J Chao et al.
Hong Jiang et al.
Aquaporins (AQPs) are critical for transmembrane water transport in response to osmotic gradients, but their gating and regulatory mechanisms remain poorly understood. A central challenge is the lack of methods to measure water flow across ...