Effect of γ-Oryzanol on the LE-LC Phase Coexistence Region of DPPC Langmuir Monolayer [0.03%]
γ-稻醇对DPPC Langmuir单分子膜LE-LC共存区域的影响
Raghavendra,Bharat Kumar,Siva N Chari
Raghavendra
We have studied the effect of relative composition of γ-Oryzanol (γ-Or) on the liquid expanded-liquid condensed phase coexistence region in the mixed Langmuir monolayer of γ-Or and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) molec...
Computational Study on Effect of KCNQ1 P535T Mutation in a Cardiac Ventricular Tissue [0.03%]
KCNQ1P535T突变的心室组织电生理效应的模拟研究
Helan Satish,Ramasubba Reddy Machireddy
Helan Satish
Heart diseases such as arrhythmia are the main causes of sudden death. Arrhythmias are typically caused by mutations in specific genes, damage in the cardiac tissue, or due to some chemical exposure. Arrhythmias caused due to mutation is ca...
Assessment of Purity, Functionality, Stability, and Lipid Composition of Cyclofos-nAChR-Detergent Complexes from Torpedo californica Using Lipid Matrix and Macroscopic Electrophysiology [0.03%]
使用脂质基质和宏观电生理评估Torpedo californica中Cyclofos-nAChR-去垢剂复合物的纯度、功能、稳定性和脂质组成
Orestes Quesada,Joel E González-Nieves,José Colón et al.
Orestes Quesada et al.
The main objective of the present study was to find detergents that can maintain the functionality and stability of the Torpedo californica nicotinic acetylcholine receptor (Tc-nAChR). We examined the functionality, stability, and purity an...
Peptide Flexibility and the Hydrophobic Moment are Determinants to Evaluate the Clinical Potential of Magainins [0.03%]
肽的柔韧性及疏水性是评价Magainins临床潜力的重要因素
Daniel Balleza
Daniel Balleza
Using a flexibility prediction algorithm and in silico structural modeling, we have calculated the intrinsic flexibility of several magainin derivatives. In the case of magainin-2 (Mag-2) and magainin H2 (MAG-H2) we have found that MAG-2 is...
Jiajing Li,Hongfei Zhang,Qian Du et al.
Jiajing Li et al.
For a long time, the physiological activity of TRP ion channels and the response to various stimuli have been the focus of attention, and the physiological functions mediated by ion channels have subtle links with the occurrence of various ...
Rapid Pacing Decreases L-type Ca2+ Current and Alters Cacna1c Isogene Expression in Primary Cultured Rat Left Ventricular Myocytes [0.03%]
快速心率抑制大鼠左室心肌细胞L型Ca2+电流并改变Cacna1c基因表达
Anne Ritzer,Tobias Roeschl,Sandra Nay et al.
Anne Ritzer et al.
The L-type calcium current (ICaL) is the first step in cardiac excitation-contraction-coupling and plays an important role in regulating contractility, but also in electrical and mechanical remodeling. Primary culture of cardiomyocytes, a w...
Enhanced Drug Uptake on Application of Electroporation in a Single-Cell Model [0.03%]
电穿孔在单细胞模型给药吸收中的应用增强
Nilay Mondal,K S Yadav,D C Dalal
Nilay Mondal
Electroporation method is a useful tool for delivering drugs into various diseased tissues in the human body. As a result of an applied electric field, drug particles enter the intracellular compartment through the temporarily permeabilized...
Hussein Riyadh Abdul Kareem Al-Hetty,Sada Jasim Abdulameer,Maha Waleed Alghazali et al.
Hussein Riyadh Abdul Kareem Al-Hetty et al.
Osteoarthritis (OA) is the most common type of arthritis. Its high prevalence, especially in the elderly, and its negative impact on physical function make it a leading cause of disability in the elderly. Joint pain as well joint stiffness ...
Interaction of Odoroside A, A Known Natural Cardiac Glycoside, with Na+/K+-ATPase [0.03%]
卡宁化合物皂甙A与Na+/K+-ATP酶的作用机制研究
Yohei Takada,Kazuhiro Kaneko,Yoshiyuki Kawakami
Yohei Takada
The nature of odoroside A, a cardiac glycoside (CG) extracted from Nerium oleander, as well as its chemical structure is quite similar to a well-known CG, ouabain possessing a steroid skeleton, a five-membered unsaturated lactone ring, and ...
Role of Cholesterol and its Biosynthetic Precursors on Membrane Organization and Dynamics: A Fluorescence Approach [0.03%]
胆固醇及其生物前体在膜组织和动态中的作用：一种荧光方法
Sandeep Shrivastava,Yamuna Devi Paila,Amitabha Chattopadhyay
Sandeep Shrivastava
Cholesterol is the most representative sterol present in membranes of higher eukaryotes, and is the end product of a long and multistep biosynthetic pathway. Lathosterol and zymosterol are biosynthetic precursors of cholesterol in Kandutsch...