RBM15B promotes hepatocellular carcinoma progression via IGF2BP1-mediated ITSN2 mRNA stabilization [0.03%]
RBM15B通过IGF2BP1介导的ITSN2 mRNA稳定促进肝细胞癌进展
Yongfang Xu,Mengqi Xiong,Wei Chen et al.
Yongfang Xu et al.
Background: N6-methyladenosine (m6A) is a chemical modification of adenosine in RNA that plays a crucial role in the regulation of gene expression. As the most abundant form of RNA chemical methylation, m6A is aberrantly ...
Hormonal management after risk-reducing surgery in BRCA-mutated triple-negative breast cancer survivors [0.03%]
BRCA突变三阴性乳腺癌幸存者风险降低手术后的激素管理
Inna Jörg,Dimitrios Chronas
Inna Jörg
Premenopausal women carrying a BRCA1 or BRCA2 mutation are frequently advised to undergo risk-reducing bilateral salpingo-oophorectomy (BSO) to lower their significantly increased lifetime risk of ovarian cancer. However, this procedure ind...
Targeting SLC6A8 suppresses tumor growth and enhances ferroptosis in hepatocellular carcinoma [0.03%]
靶向SLC6A8可抑制肝细胞癌的肿瘤生长并增强铁死亡效应
Wenfang Bao,Yang Yu,Guofeng Yu et al.
Wenfang Bao et al.
Background: Hepatocellular carcinoma (HCC) persists as a therapeutic challenge owing to restricted treatment alternatives and the dearth of effective biomarkers. The creatine transporter SLC6A8 has been documented to part...
From mechanism to clinic: a panoramic perspective on targeting HMOX1 to overcome drug resistance [0.03%]
从机制到临床：全景式综述靶向HMOX1克服耐药性研究进展
Dan Huang,Yuxin Ma,Wenya Gao et al.
Dan Huang et al.
Drug resistance is a pivotal factor leading to the failure of cancer therapy, within which heme oxygenase-1 (HMOX1) plays a complex and paradoxical dual role. On one hand, HMOX1 protects cancer cells from oxidative damage induced by chemoth...
Real-world monitoring strategies and predictors guiding the transition from active surveillance to treatment in ISUP 1 prostate cancer [0.03%]
国际前列腺癌分类1期的主动监测转为治疗的预测因素和真实世界监测策略
Giulia Giannini,Amer Mousa,Eberhard Steiner et al.
Giulia Giannini et al.
Purpose: Active surveillance (AS) is the standard approach for managing ISUP 1 prostate cancer (PCa), ensuring oncological safety while minimizing overtreatment. However, AS protocols vary significantly. This study assess...
Modified clear cell likelihood score and a new CAT score in the assessment of indeterminate small renal masses [0.03%]
修改后的透明细胞可能性评分和新的CAT评分在评估不确定小肾肿瘤中的应用
Tomasz Blachura,Patrycja S Matusik,Aleksander Kowal et al.
Tomasz Blachura et al.
Purpose: In recent decades, small renal masses (SRMs) have become common incidental findings in cross-sectional studies; however, a widely implemented approach for the characterization of SRMs is still lacking. Thus, in t...
Crosstalk between mitophagy and breast cancer: mechanisms of action and clinical applications [0.03%]
线粒体自噬与乳腺癌的相互作用：作用机制及临床应用
Kun Rui,Jingjing Qiu,Minghao Li et al.
Kun Rui et al.
Mitophagy, a key mechanism of selective autophagy, maintains cellular homeostasis by removing dysfunctional mitochondria, and its dysregulation is closely associated with tumor initiation and progression. As breast cancer remains one of the...
Comparative cross-methodological analysis of the IDH-wildtype glioblastoma tumor microenvironment [0.03%]
IDH野生型胶质母细胞瘤肿瘤微环境的比较跨方法分析
Pinar Cakmak,Jennifer H Lun,Miriam Köhler et al.
Pinar Cakmak et al.
Purpose: Glioblastoma, IDH-wildtype is a highly aggressive and often recurrent brain malignancy characterized by a profoundly immunosuppressive and heterogeneous tumor microenvironment. In this study, we aimed to systemat...
Personalizing cancer risk: a systematic review of risk communication strategies [0.03%]
癌症风险个性化：一项系统性回顾研究风险沟通策略
Akila Anandarajah,Rachelle Roy,Grace Cross et al.
Akila Anandarajah et al.
Purpose: Personalized risk communication (PRCom) can help individuals make informed decisions about electing to undergo cancer screening based on their specific risk. In this systematic review, we examined existing risk communication strate...
When AI joins the table: evaluating large language model performance in soft tissue sarcoma tumor board decisions [0.03%]
当AI加入讨论：评估大型语言模型在软组织肉瘤肿瘤委员会决策中的表现
Reza Dehdab,Saif Afat,Fiona Mankertz et al.
Reza Dehdab et al.
Objectives: Multidisciplinary tumor boards (MDTs) are critical for the personalized management of soft tissue sarcomas (STS), but they are limited by time, costs, and resource demands. With recent advances in large langua...