KLRG1 defines a distinct tumor-infiltrating granzyme K+ CD8 + T cell population [0.03%]
KLRG1定义了具有细胞毒性的CD8+T细胞群
Jerin Thomas,Sophia Kennedy,Stella Darcy et al.
Jerin Thomas et al.
Purpose: Emerging evidence indicates that granzyme K expressing tumor infiltrating CD8 + T-cells play a critical role in mediating anti-tumor T-cell immunity and immunotherapy treatment response. However, precise characte...
Diagnostic and therapeutic challenges in claudin 18.2-positive gastric cancer treated with zolbetuximab: Intrapatient heterogeneity or secondary loss of expression? [0.03%]
Claudin 18.2阳性胃癌接受zolbetuximab治疗的诊断和治疗挑战：病体内异质性或继发性表达缺失？
O Morath,U Lindig,K Katenkamp et al.
O Morath et al.
Background: Claudin 18.2 (CLDN18.2) has emerged as a promising therapeutic target in advanced gastric cancer (GC). Data on resistance to zolbetuximab due to secondary antigen loss or baseline intrapatient heterogeneity ar...
No-touch versus conventional radiofrequency ablation for treating solitary recurrent hepatocellular carcinoma ≤ 3 cm: a retrospective cohort study [0.03%]
无接触与传统射频消融治疗单发≤3cm的小肝癌复发的回顾性队列研究
Guodong Wu,Xia Ou,Mengda Zou et al.
Guodong Wu et al.
Objective: This study aimed to compare the outcomes of no-touch radiofrequency ablation (NT-RFA) and conventional RFA (C-RFA) in the treatment of solitary recurrent hepatocellular carcinoma (rHCC) ≤ 3 cm. ...
Exosome-based vaccines in cancer immunotherapy: antitumor mechanisms, engineering strategies, and challenges [0.03%]
癌症免疫治疗中基于外泌体的疫苗：抗肿瘤机制、工程策略与挑战
Huanling Zhou,Yuanxin Shi,Yueyue Wang et al.
Huanling Zhou et al.
Exosome-based vaccines hold significant promise in cancer immunotherapy, yet their native forms face inherent challenges, including imprecise targeting, suboptimal immunogenicity, and poor controllability of antigen loading. This review pos...
Investigating the oncogenic potential of MTHFD2 in oral squamous cell carcinoma [0.03%]
MTHFD2在舌鳞癌中的致癌潜能研究
Jiusong Hang,Wei Wang,Simin Li et al.
Jiusong Hang et al.
Purpose: Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2), a mitochondrial bifunctional enzyme, is reportedly upregulated in several malignancies, demonstrating cancer-associated dysregulation. However, its functional c...
The features and prognostic value of ARID1A mutation and protein expression in endometrial cancer of no specific molecular profile (NSMP) subtype: a retrospective study in a large Chinese cohort [0.03%]
ARID1A基因突变和蛋白表达在子宫内膜癌非特异性分子分型亚型中的特征及预后价值：一项对中国大型队列的回顾性研究
Xinhui Yuan,Mengyuan Cai,Changmin Yu et al.
Xinhui Yuan et al.
Purpose: Endometrial cancer (EC) of no specific molecular profile (NSMP) subtype constitutes the majority of EC and shows significant heterogeneity. This study aims to explore the role of ARID1A mutation and protein expre...
Efficacy and safety of neoadjuvant chemoimmunotherapy versus neoadjuvant chemoradiotherapy in locally advanced resectable esophageal squamous cell carcinoma [0.03%]
新辅助化疗免疫治疗与新辅助放化疗治疗局部晚期食管鳞癌患者的疗效和安全性比较：一项随机、开放标签的3期临床试验
Yuanyuan Jiang,Zijie Wu,Wei Wang et al.
Yuanyuan Jiang et al.
Objective: To compare the efficacy and safety of neoadjuvant chemoradiotherapy (NCRT) versus chemoimmunotherapy (NCIT) in resectable locally advanced esophageal squamous cell carcinoma (LA-ESCC). ...
Ubiquitin C-terminal hydrolase L3 promotes liver cancer cell proliferation by modulating the AMP-activated protein kinase signaling pathway [0.03%]
泛素羧基末端水解酶L3通过调节腺苷酸活化蛋白激酶信号通路促进肝癌细胞增殖
Yan Liu,Jingbo Lu,Hao Wang et al.
Yan Liu et al.
Purpose: The deubiquitinase Ubiquitin C-Terminal Hydrolase L3 (UCHL3) is highly expressed in multiple cancer types and generally considered as an oncogene. However, its functions in liver cancer are unclear. This study in...
Prognostic factors for lymph node infestation, long-term survival and recurrence rates in patients with vaginal cancer: a population-based study in Germany [0.03%]
基于德国人口的阴道癌淋巴结侵犯、长期生存率和复发率的预后因素研究
Shirin Wenning,Michael Gerken,Thomas Papathemelis et al.
Shirin Wenning et al.
Purpose: Vaginal cancer (ICD-10: C52) is one of the rarest gynecological malignancies, with limited research on its frequency, long-term survival, therapy-dependent survival, and follow-up of recurrences. This knowledge d...
Nora Tabea Sibert,Maike Wellbrock,Ahmed Bedir et al.
Nora Tabea Sibert et al.
Background: Social inequalities in cancer constitute a major public health challenge. A lower socioeconomic position (SEP) is consistently associated with higher exposure to cancer risk factors, lower participation in scr...