The efficacy and toxicity of TRT on metastatic NSCLC in patients treated with targeted therapy and chemoimmunotherapy [0.03%]
靶向及免疫化疗的转移性非小细胞肺癌患者雄激素剥夺治疗的有效性和毒性分析
Lishan Xue,Jinquan Yao,Qian Xu et al.
Lishan Xue et al.
Purpose: The role of thoracic radiotherapy (TRT) combined with first-line systemic therapy for metastatic non-small cell lung cancer (NSCLC) remains controversial. Its application is not routinely recommended due to incon...
High serum ferritin is associated with genetic instability in myelodysplastic neoplasms [0.03%]
血清铁蛋白升高与骨髓增生异常肿瘤的遗传不稳定性相关
Christina Ganster,Hannes Treiber,Gina Westhofen et al.
Christina Ganster et al.
Purpose: Serum ferritin is an independent prognostic marker in myelodysplastic neoplasms (MDS) and serves as a surrogate parameter for iron overload. Oxidative stress derived from iron overload may induce genomic damage, ...
Clinicopathological features and prognostic analysis of 30 patients with laryngeal and hypopharyngeal adenoid cystic carcinoma: a single-center retrospective study [0.03%]
喉咽腺样囊性癌的临床病理特征及预后分析：单中心回顾性研究
Mingzhu Wang,Jing Zhou,Tingyao Ma et al.
Mingzhu Wang et al.
Purpose: To evaluate clinical characteristics, treatment outcomes, and prognostic factors in patients with laryngeal and hypopharyngeal adenoid cystic carcinoma (LHACC). ...
Phosphorylated mTOR immunohistochemistry-guided use of temsirolimus in recurrent IDH-wildtype glioblastoma: a real-world retrospective series [0.03%]
基于磷酸化mTOR免疫组化的替西罗莫司治疗IDH野生型复发胶质母细胞瘤的现实世界回顾系列研究
Teresa Schmidt,Mavie Surau,Christoph Oster et al.
Teresa Schmidt et al.
OLFM4 orchestrates the immunosuppressive microenvironment and drives gallbladder cancer progression [0.03%]
OLFM4调控免疫抑制微环境并促进胆囊癌进展
Wenxin Li,Kun Liu,Fan Yang et al.
Wenxin Li et al.
Purpose: Gallbladder cancer (GBC) is the most common biliary tract malignancy, characterized by complex microenvironment and poor prognosis. Olfactomedin-4 (OLFM4) has been identified as a key regulator of GBC progression...
Improving the diagnosis of renal tumours of young people through integrated molecular analysis [0.03%]
通过综合分子分析改进年轻人大肾肿瘤的诊断
Sarah M Leiter,Aisosa O Guobadia,Ben Fleming et al.
Sarah M Leiter et al.
Background: Renal tumours account for one in twenty paediatric cancers, with Wilms tumour (WT) the most common in young children and renal cell carcinoma (RCC) predominating in adolescents and young adults. Diagnostic wor...
Precision cancer medicine in Europe: a mixed-methods study on infrastructure for extended molecular diagnostics [0.03%]
精准癌症医学在欧洲的现状：扩展分子诊断基础设施的混合研究方法研究
Pia S Henkel,Kine Pedersen,Kjetil Taskén et al.
Pia S Henkel et al.
Purpose: Precision cancer medicine (PCM), targeting cancer treatment to patients' individual genomic profiles, has the potential to improve diagnosis and outcomes substantially. Implementing PCM in healthcare systems requ...
Allogeneic CD56+ cell-based immunotherapy in a patient with Fanconi anemia developing acute myeloid leukemia [0.03%]
Fanconi贫血症并发急性髓系白血病患者采用同种异体CD56阳性细胞免疫治疗一例
Mehdi Bakhtiyari Dovvombaygi,Amin Shahbaz Ghasabeh,Shiva Eskandarian et al.
Mehdi Bakhtiyari Dovvombaygi et al.
Background: Fanconi anemia (FA) is a rare inherited disorder characterized by genomic instability, bone marrow failure, and a markedly increased risk of developing acute myeloid leukemia (AML). The intrinsic hypersensitiv...
Interventional management of unresectable pancreatic cancer using transarterial chemoembolization and microwave ablation: a single-center evaluation over 12 years [0.03%]
不可切除胰腺癌经导管动脉化疗栓塞联合微波消融的介入治疗体系建立及疗效评估
Thomas J Vogl,Ruxandra Cojocaru,Daniel M Dahm et al.
Thomas J Vogl et al.
Purpose: The aim of this study is to evaluate the safety and clinical outcomes of combined transarterial chemoembolization (TACE) and microwave ablation (MWA) as well as TACE monotherapy in patients with unresectable panc...
CT-based intratumoral, peritumoral radiomics and clinical features: a combined model for perineural invasion prediction in PDAC [0.03%]
基于CT的肿瘤内、肿瘤周影像组学及临床特征结合模型预测胰腺导管腺癌患者癌性神经侵犯阳性状况
Qi Lan,Yuying Wang,Fan Xia et al.
Qi Lan et al.
Purpose: To develop and validate a general radiomics nomogram capable of identifying perineural invasion (PNI) status in pancreatic ductal adenocarcinoma (PDAC) patients. ...