LAC-TME classifier: machine learning-driven model predicts survival and prioritizes targeted therapy in clear cell renal cell carcinoma [0.03%]
LAC-TME分类器：一种机器学习驱动的模型可预测透明细胞肾细胞癌患者的生存率并优先选择靶向治疗方案
Jiawei He,Lin Qi,Yi Cai et al.
Jiawei He et al.
Background: Clear cell renal cell carcinoma (ccRCC) is a major type of kidney cancer, making up about 80% of cases, with advanced stages showing low survival rates. Current treatments face challenges like toxicity and dru...
Hematological parameters as predictors of oral cancer prognosis: a systematic review and meta-analysis [0.03%]
血液学参数作为口腔癌预后的预测因素：系统评价和 Meta 分析
Abdullah M Alshahrani,Kanwalpreet Kaur,Ravinder S Saini et al.
Abdullah M Alshahrani et al.
Objective: This systematic review and meta-analysis aimed to assess the prognostic value of pre-treatment hematological parameters, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platel...
Efficacy and safety of neoadjuvant therapy combined with immunotherapy in MMR‑proficient/microsatellite stable non‑metastatic rectal cancer: a systematic review and meta‑analysis [0.03%]
mismatch修复型/微卫星稳定非转移性直肠癌新辅助治疗联合免疫治疗的疗效和安全性：系统评价和meta分析
Yuegang Li,Chengcheng Han,Jianqiang Tang
Yuegang Li
Objective: To comprehensively evaluate the efficacy and safety of neoadjuvant therapy combined with immunotherapy in patients with MMR-proficient/microsatellite stable (pMMR/MSS) non-metastatic rectal cancer. ...
Phage therapy and the microbiome in hematologic malignancies: opportunities, mechanisms, and early evidence [0.03%]
噬菌体治疗和微生物组在血液系统恶性肿瘤中的作用：机遇、机制及初步证据
Juanwen Zhang,Jin Liu,Alireza Bayani
Juanwen Zhang
Hematologic malignancies remain among the most difficult cancers to treat, challenged by profound heterogeneity, treatment-induced immune dysfunction, and the frequent emergence of drug resistance. Beyond tumor-intrinsic mechanisms, dysbios...
Impact of preoperative geriatric screening and comorbidity assessment in patients with vulvar and vaginal cancer [0.03%]
术前老年患者筛查和合并症评估对外阴及阴道癌症的影响
Valerie Catherine Linz,Emma Liebau,Markus Schepers et al.
Valerie Catherine Linz et al.
Purpose: Patients with vulvar (VC) and vaginal (VaC) cancer are often frail and should be prescreened before a time-consuming comprehensive geriatric assessment (CGA). This study assessed the impact of the preoperatively ...
157Gd-DHK: enhancing targeted gadolinium neutron capture for pancreatic adenocarcinoma [0.03%]
157GD-DHK：增强针对胰腺癌的钆中子捕获作用
Liang Xie,Cuiping Song,Jialin Qin et al.
Liang Xie et al.
Gadolinium-neutron capture therapy (Gd-NCT) employs Gadolinium (Gd) isotopes and thermal neutrons to specifically target and kill cancer at cells level. This study investigates the targeting efficacy of 157Gd-DOTA-HK (DHK), a novel agent de...
Concept and feasibility of privacy-preserving record linkage of cancer registry data and claims data in Germany: results from the DigiNet study on stage IV non-small cell lung cancer [0.03%]
德国癌症登记数据和索赔数据隐私保护记录链接的概念和可行性：来自DigiNet研究中IV期非小细胞肺癌的结果
Anika Kästner,Christopher Hampf,Pia Naumann et al.
Anika Kästner et al.
Objective: While cancer registry and health insurance data are valuable resources for oncological health services research, these are rarely linked at the individual level due to data protection concerns and technical lim...
TKI plus ICI versus ICI alone in high tumor burden hepatocellular carcinoma: a retrospective cohort study [0.03%]
高肿瘤负荷的肝细胞癌患者接受靶向治疗联合免疫治疗与单独使用免疫治疗的疗效比较：一项回顾性队列研究
Po-Ting Lin,Wei Teng,Wei-Ting Chen et al.
Po-Ting Lin et al.
Background: Combination regimens and monotherapy are both employed in the treatment of hepatocellular carcinoma (HCC). However, the optimal combination regimen for specific scenarios remains unclear. Therefore, our aim is...
The c.1744G > C, p.(Glu582Gln) missense variant in coding exon 14 of APC increases skipping of a natural occurring isoform and causes Familial Adenomatous Polyposis [0.03%]
编码 exon 14 中的错义变异 c.1744G > C，p。(Glu582Gln) 可增加自然发生的异构体的跳读并导致家族性腺瘤性息肉病
Anne Marie Jelsig,Maria Bejerholm Boelman,Ulf Birkedal et al.
Anne Marie Jelsig et al.
Insights into SUMOylation in gastric cancer: molecular mechanisms and emerging therapeutic opportunities [0.03%]
胃癌中的SUMO化研究：分子机制和新兴治疗机会
Peyman Tabnak,Mohammad Ebrahimnezhad
Peyman Tabnak
Gastric cancer remains a significant global health challenge due to its aggressive behavior, high mortality rates, and limited treatment success. Growing research underscores the critical role of SUMOylation, a reversible post-translational...