The chlorite adduct of aquacobalamin: contrast with chlorite dismutase [0.03%]
氯化高铁血红素的氯化物加合物：与氯酸脱氨酶对比
Maria Lehene,Cezara Zagrean-Tuza,Stefania D Iancu et al.
Maria Lehene et al.
In the reaction of aquacobalamin (aquaCbl) with chlorite, a stable species is detected and assigned as a Co(III)-chlorite complex, Co(III)-OClO-. Its UV-Vis spectrum is almost identical to that of aquaCbl, except for some minor differences ...
Donut-shaped [NaP5W30O110]14- polyoxometalate as a promising antidiabetic drug-candidate: putative mechanisms of action [0.03%]
甜甜圈形[NaP5W30O110]14-杂多酸盐作为有前景的抗糖尿病药物候选体：可能的作用机制
Marko Dinčić,Mirjana B Čolović,Jasna Todorović et al.
Marko Dinčić et al.
The aim of this study was to elucidate the potential mechanism of the antihyperglycemic action of the donut-shaped Preyssler-Pope-Jeannin polyanion salt (NH4)14[NaP5W30O110] 31H2O (NaP5W30) and its effect on metabolic disorders associated w...
The activation of the metal-containing regulatory protein NiaR from Thermotoga maritima by its effector, nicotinic acid [0.03%]
来自海洋栖热菌的含金属调节蛋白NiaR及其效应物烟酸的激活作用
Wai Chung Dorothy Cheng,Yuxin Li,Maileen Nakashima et al.
Wai Chung Dorothy Cheng et al.
NiaR is a regulatory protein that represses the expression of proteins involved in the de novo biosynthesis and uptake of nicotinic acid (NA), with NA acting as a co-repressor. The previously published structure of NiaR from Thermotoga mari...
A semisynthetic, multicofactor artificial metalloenzyme retains independent site activity [0.03%]
一种半合成含多元辅因子的人工金属酶保持独立活性站点功能
Ashlee E Wertz,Ilmari Rosenkampff,Philippe Ibouanga et al.
Ashlee E Wertz et al.
Native metalloenzymes are unparalleled in their ability to perform efficient small molecule activation reactions, converting simple substrates into complex products. Most of these natural systems possess multiple metallocofactors to facilit...
Brighton A Skeel,Daniel L M Suess
Brighton A Skeel
Iron-sulfur proteins perform a wide variety of reactions central to the metabolisms of all living organisms. Foundational to their reaction chemistry are the rich electronic structures of their constituent Fe-S clusters, which differ in imp...
Deepak Shrestha,Bett Kimutai,Christine S Chow
Deepak Shrestha
The discovery of cisplatin (cisPt) as an effective anticancer agent was a milestone in the health industry. Despite its success, undesired side effects and acquired resistance still limit the therapeutic usefulness of cisPt. Intrastrand add...
Nitric oxide transfer between nominal Fe and Co biomimetics of the nitrile hydratase active site [0.03%]
氮芥水合酶活性部位拟物间的亚硝酸根传递：铁和钴物种之间的差异性研究
Sarnali Sanfui,Manish Jana,Nadia Small et al.
Sarnali Sanfui et al.
Related to the inactive form of nitrile hydratase, NHase, that contains Fe(NO) within tripeptide N2S2 binding environment, the NO transfer reactivity of (bis-mercaptoethane diazacycloheptane)Fe(NO) and (bis-mercaptoethane diazadimethylethan...
Comparison of lipid dynamics and permeability in styrene-maleic acid and diisobutylene-maleic acid copolymer lipid nanodiscs by electron paramagnetic resonance spectroscopy [0.03%]
电子顺磁共振光谱法比较苯乙烯-马来酸和二异丁烯-马来酸共聚物脂质纳米盘的动力学和渗透性
Andrew K Morris,Robert M McCarrick,Gary A Lorigan
Andrew K Morris
Lipid nanoparticles formed with copolymers are a new and increasingly powerful tool for studying membrane proteins, but the extent to which these systems affect the physical properties of the membrane is not completely understood. This is c...
Anticancer potential of benzo[b]thiophene functionalized thiosemicarbazone ligands and their organoruthenium complexes [0.03%]
苯并噻吩功能化半碳半氨醇配体及其有机钌配合物的抗肿瘤潜力
Emine Öztürk,Elif Subaşı,Gizem Kurşunluoğlu et al.
Emine Öztürk et al.
As novel promising anticancer candidates, the piano-stool type complexes of ruthenium, [RuCl(η6-p-cymene)(N,S-Ln)]PF6, K1-4, were synthesized from the reaction of the substituted benzo[b]thiophene based thiosemicarbazone ligands (L1-4) wit...
Iron-sulfur cluster redox chemistry and dimer dissociation in the outer mitochondrial membrane protein, mitoNEET [0.03%]
外线粒体膜蛋白mitoNEET中的铁硫团簇氧化还原化学与二聚体解离
Kanita A Chaudhry,Krishani K Rajanayake,Richard T Carroll et al.
Kanita A Chaudhry et al.
The outer mitochondrial membrane protein known as mitoNEET was discovered when it was labeled by a photoaffinity derivative of the anti-diabetes medication, pioglitazone. The biological role for mitoNEET and its specific mechanism for achie...