Impact of a strategy using multiplex PCR on targeted antibiotic therapy for patients with suspected ventilator-associated pneumonia or hospital-acquired pneumonia requiring mechanical ventilation: a randomized, single-blind trial [0.03%]
多重PCR策略对疑似呼吸机相关性肺炎或需要机械通气的医院获得性肺炎的目标抗生素治疗的影响：随机单盲试验
Guillaume Millot,Anahita Rouze,Frédéric Wallet et al.
Guillaume Millot et al.
Purpose: Ventilator-associated pneumonia (VAP) and hospital-acquired pneumonia requiring mechanical ventilation (vHAP) are frequent in intensive care units and require prompt diagnosis. The FilmArray Pneumonia Panel (FAPP...
Mathieu Jozwiak,Mervyn Singer,Djillali Annane
Mathieu Jozwiak
Respiratory mechanics modifies the impact of ventilator settings on clinical outcome in patients with acute brain injury [0.03%]
呼吸力学改变重症脑损伤患者机械通气设置对临床结局的影响
Domenico Luca Grieco,Alessandro Stronati,Chiara Robba et al.
Domenico Luca Grieco et al.
Purpose: To investigate whether respiratory system elastance (ERS) modifies the associations of tidal volume (VT) and respiratory rate with clinical outcomes in mechanically ventilated patients with acute brain injury. ...
Early red blood cell transfusion strategy in septic shock among patients with cancer: the TRANSPORT randomized controlled trial [0.03%]
脓毒症休克合并肿瘤患者的早期红细胞输注策略：一项随机对照研究（TRANSPORT试验）
Frédéric Pène,Clara Vigneron,Antoine Lafarge et al.
Frédéric Pène et al.
Purpose: Septic shock in cancer patients remains associated with a grim prognosis. With regard to the high prevalence of anemia, the optimal hemoglobin target to restore tissue oxygenation remains uncertain. ...
Randomized Controlled Trial
Intensive care medicine. 2026 Oct;52(10):2096-2107. DOI:10.1007/s00134-026-08582-4 2026
Machine learning for prediction in secondary hemophagocytic lymphohistiocytosis: real progress, real limits, and the potential of synthetic data [0.03%]
机器学习在继发性噬血细胞综合征预测中的应用：实证进步、局限及合成数据的潜力
Louis Delamarre,Jan-Inge Henter
Louis Delamarre
ARDS management beyond the guidelines: a practical physiology-based approach to individualized care [0.03%]
超越指南的急性呼吸窘迫综合征管理：基于生理学的个体化护理实用方法
Nattapat Wongtirawit,Luca Salvatore Menga,Roberto Brito et al.
Nattapat Wongtirawit et al.
Practice guidelines for acute respiratory distress syndrome (ARDS) have established lung-protective ventilation as the standard of care, but optimized management requires further individualization to each patient's specific physiological ch...
Fully flexing the potential of AI in intensive care: reinforcement learning with randomization when needed [0.03%]
充分挖掘人工智能在重症监护中的潜力：必要时进行随机化的强化学习
Paul Elbers,Ari Ercole,Derek C Angus
Paul Elbers
Corticosteroids in ARDS: old controversies, new insights, and future directions [0.03%]
ARDS的皮质类固醇治疗：老话题，新启示和未来方向
Tara Daoud,Jesus Villar,Djillali Annane
Tara Daoud
Corticosteroids modulate key inflammatory and fibroproliferative pathways involved in ARDS through genomic and non-genomic glucocorticoid receptor signaling. Advances in ARDS pathophysiology have highlighted the importance of timing, inflam...
Ultra-early versus early adjunctive vasopressin initiation after norepinephrine escalation in septic shock: a target trial emulation [0.03%]
在多巴胺升阶梯治疗后超早期与早期联合使用加压素治疗脓毒性休克：一种靶试验模拟研究
Takaya Nakashima,Taiga Ichinomiya,Mikio Nakajima et al.
Takaya Nakashima et al.
Purpose: The optimal timing of adjunctive vasopressin after norepinephrine escalation in septic shock remains uncertain. We emulated a target trial comparing ultra-early vasopressin initiation within 0-3 h with early init...
Katerina Rusinova,Robert Rusina,Steven Z Pantilat
Katerina Rusinova