Genome-wide association analysis of canine atopic dermatitis and identification of disease related SNPs [0.03%]
犬特应性皮炎的基因组范围关联分析及鉴定与疾病相关的SNP位点
Shona Hiedi Wood,Xiayi Ke,Tim Nuttall et al.
Shona Hiedi Wood et al.
In humans, genome-wide association studies (GWAS) have been shown to be an effective and thorough approach for identifying polymorphisms associated with disease phenotypes. Here, we describe the first study to perform a genome-wide associat...
NK gene complex and chromosome 19 loci enhance MHC resistance to murine cytomegalovirus infection [0.03%]
自然杀伤基因复合体和第19号染色体上的座位点增强了主要组织相容性复合体对抗小鼠巨细胞病毒的抵抗力
Michael D Stadnisky,Ani Manichaikul,Alyssa G Lundgren et al.
Michael D Stadnisky et al.
An H-2(k) MHC locus is critical for murine cytomegalovirus (MCMV) resistance in MA/My mice and virus control is abolished if H-2(k) is replaced with H-2(b) MHC genes from MCMV-susceptible C57L mice. Yet, H-2(k) resistance varies with geneti...
Susceptibility to Crohn's disease is mediated by KIR2DL2/KIR2DL3 heterozygosity and the HLA-C ligand [0.03%]
克罗恩病易感性由KIR2DL2/KIR2DL3杂合性和HLA-C配体介导
Jill A Hollenbach,Martha B Ladner,Koy Saeteurn et al.
Jill A Hollenbach et al.
In the present study, we investigated the relationship between the KIR loci and the genes encoding their HLA ligands and genetic susceptibility to Crohn's disease (CD). Analyses of the interactions between KIR3DL1, KIR2DL1, KIR2DL2, and KIR...
Identification of novel MHC class I sequences in pig-tailed macaques by amplicon pyrosequencing and full-length cDNA cloning and sequencing [0.03%]
通过靶向扩增子测序和全长cDNA克隆及序列测定在食蟹猴中鉴定新的MHC I类基因编码区序列
Claire E O&#x;Leary,Roger W Wiseman,Julie A Karl et al.
Claire E O&#x;Leary et al.
Pig-tailed macaques (Macaca nemestrina) provide important animal models in biomedical research, but utility of this species for HIV and other disease pathogenesis research is limited by incomplete knowledge of major histocompatibility compl...
TCRJ and BCRJ gene segments contain 5' D-segment sequences that contribute to repertoire diversity [0.03%]
TCRJ和BCRJ基因片段含有贡献于多样性的5'D节段序列
Christopher L Reardon
Christopher L Reardon
T cell receptor (TCR) and B cell receptors (BCR) junctions, also known as the CDR3, are where the V, D, and J gene segments converge, coding for a loop structure important for contacting ligands. J segments contribute to the formation of th...
Comparative Study
Immunogenetics. 2009 Oct;61(10):673-87. DOI:10.1007/s00251-009-0388-5 2009
Mortality in adult intensive care patients with severe systemic inflammatory response syndromes is strongly associated with the hypo-immune TNF -238A polymorphism [0.03%]
成人重症监护患者严重全身炎症反应综合征的死亡率与低免疫TNF-238A多态性密切相关
John V Pappachan,Tim G Coulson,Nicholas J A Child et al.
John V Pappachan et al.
The systemic inflammatory response syndrome (SIRS) is associated with activation of innate immunity. We studied the association between mortality and measures of disease severity in the intensive care unit (ICU) and functional polymorphisms...
Distinct genetic control of parasite elimination, dissemination, and disease after Leishmania major infection [0.03%]
利什曼原虫感染后机体对病原清除、播散及发病的不同遗传控制机制
Iryna Kurey,Tetyana Kobets,Helena Havelková et al.
Iryna Kurey et al.
Elimination of pathogens is the basis of host resistance to infections; however, relationship between persisting pathogens and disease has not been clarified. Leishmania major infection in mice is an important model of host-pathogen relatio...
Temporal evolution of the ABO allele frequencies in the Canary Islands: the impact of the European colonization [0.03%]
西欧人殖民对加那利群岛ABO基因频率的影响：基于血型遗传的分析
Rosa Fregel,Eva Betancor,Nicolás M Suárez et al.
Rosa Fregel et al.
The indigenous Canary Islands population suffered a strong cultural and genetic impact when they were colonized by Europeans in the fifteenth century. The molecular analysis of the ABO blood group gene on aboriginal and seventeenth to eight...
Polymorphisms of NKG2D ligands: diverse RAET1/ULBP genes in northeastern Thais [0.03%]
NKG2D配体多态性：东北泰人的RAET1 / ULBP基因的多样性
Amornrat V Romphruk,Arunrat Romphruk,Taeko K Naruse et al.
Amornrat V Romphruk et al.
Unique long 16 (UL-16)-binding proteins (ULBP) or retinoic acid early transcripts-1 (RAET1) are ligands to the activating receptor, NKG2D. The human RAET1/ULBP gene family is identified as ten members (RAET1E to N) with six loci encoding fo...
FcepsilonRIalpha gene -18483A>C polymorphism affects transcriptional activity through YY1 binding [0.03%]
-18483A>C多态性通过YY1结合影响转录活性
Daniel P Potaczek,Keiko Maeda,Qing-Hui Wang et al.
Daniel P Potaczek et al.
Three frequent genetic polymorphisms in the human high-affinity IgE receptor alpha-subunit (FcepsilonRIalpha) were shown to be associated with allergic disorders and/or total serum IgE levels in allergic patients. Two of these were previous...