Major histocompatibility complex variation and evolution at a single, expressed DQA locus in two genera of elephants [0.03%]
象属和长鼻属大象中单个表达的DQA基因座上的主要组织相容性复合体多态性和进化关系
Elizabeth A Archie,Tammy Henry,Jesus E Maldonado et al.
Elizabeth A Archie et al.
Genes of the vertebrate major histocompatibility complex (MHC) are crucial to defense against infectious disease, provide an important measure of functional genetic diversity, and have been implicated in mate choice and kin recognition. As ...
Nathan D Meeker,Alexandra C H Smith,J Kimble Frazer et al.
Nathan D Meeker et al.
Zebrafish (Danio rerio) has become an increasingly important model for immunological study. Its immune system is remarkably similar to that of mammals and includes both the adaptive and innate branches. Zebrafish T cells express functional ...
MHC class II DRB1 gene polymorphism in the pathogenesis of Maedi-Visna and pulmonary adenocarcinoma viral diseases in sheep [0.03%]
绵羊主要组织相容性复合体II类等位基因多态性在绵羊霉形体病毒感染发病机制中的作用研究
Amaia Larruskain,Esmeralda Minguijón,Koldo García-Etxebarria et al.
Amaia Larruskain et al.
Ovine pulmonary adenocarcinoma (OPA) and Maedi-Visna (Maedi) are two chronic respiratory diseases of retroviral origin which occur worldwide. It is known that different host genetic factors influence the outcome of viral infections. To dete...
Single-nucleotide polymorphisms in the IL2RA gene are associated with age at diagnosis in late-onset Finnish type 1 diabetes subjects [0.03%]
IL2RA基因中的单核苷酸多态性与芬兰晚发1型糖尿病患者的诊断年龄相关
Matthew W Klinker,Jennifer J Schiller,Victoria L Magnuson et al.
Matthew W Klinker et al.
The onset of type 1 diabetes can occur at any age, with as many as half of all cases diagnosed after age 15. Despite this wide distribution in age at diagnosis, most genetic studies focus on cases diagnosed in childhood or during early adul...
Coordinate loss of MHC class II expression in the diffuse large B cell lymphoma cell line OCI-Ly2 is due to a novel mutation in RFX-AP [0.03%]
弥漫性大B细胞淋巴瘤细胞系OCI-Ly2中MHC-II表达丢失的坐标缺陷由RFXANK中的新突变引起
Meghan Bushway,Kelly A Cycon,Kathleen Mulvaney et al.
Meghan Bushway et al.
Loss of major histocompatibility complex class II (MHCII) antigen expression on diffuse large B cell lymphoma (DLBCL) corresponds closely with significant decreases in patient survival. However, the mechanisms accounting for MHCII loss in D...
Julia M Phillips-Quagliata
Julia M Phillips-Quagliata
A set of mouse IgAs containing amino acids differing amongst the six alpha-chain allotypes was constructed by mutating an S107-IgA plasmid and transfecting it into a non-producer myeloma cell line along with a kappa-chain plasmid. The secre...
Jeffrey A Yoder,Poem M Turner,Phillip D Wright et al.
Jeffrey A Yoder et al.
Novel immune-type receptors (NITRs) are encoded by large multi-gene families and share structural and signaling similarities to mammalian natural killer receptors (NKRs). NITRs have been identified in multiple bony fish species, including z...
Munir Akkaya,A Neil Barclay
Munir Akkaya
Paired receptors are groups of closely related membrane proteins that have the potential to either inhibit or activate. The CD200R family consists of one inhibitory member, CD200R and various numbers of activating genes according to species...
European wild boars and domestic pigs display different polymorphic patterns in the Toll-like receptor (TLR) 1, TLR2, and TLR6 genes [0.03%]
欧洲野猪和家猪的Toll样受体（TLR）1、TLR2和TLR6基因多态性模式不同
Ingrid-Maria Bergman,Johan K Rosengren,Kjell Edman et al.
Ingrid-Maria Bergman et al.
During the last decade, the Toll-like receptors (TLRs) have been extensively studied, and their immense importance in innate immunity is now being unveiled. Here, we report pronounced differences--probably reflecting the domestication proce...
Comparative Study
Immunogenetics. 2010 Jan;62(1):49-58. DOI:10.1007/s00251-009-0409-4 2010
Polymorphism and signatures of selection in the multimammate rat DQB gene [0.03%]
多乳腺鼠DQB基因的多态性及选择信号研究
Joëlle Goüy de Bellocq,Herwig Leirs
Joëlle Goüy de Bellocq
In order to test if DQB is a good candidate marker to investigate the relationship between major histocompatibility complex genes and pathogens in natural populations of Mastomys natalensis, we assessed the polymorphism and evolutionary his...