Philip H Kruse,Cornelia Rosner,Lutz Walter
Philip H Kruse
Certain combinations of the killer immunoglobulin-like receptors (KIR) and major histocompatibility complex class I ligands in humans predispose carriers to a variety of diseases, requiring sophisticated genotyping of the highly polymorphic...
Is there a role for mannan-binding lectin in the diagnosis of inflammatory bowel disease? [0.03%]
甘露聚糖结合凝集素在炎症性肠病诊断中的作用几何？
Christina Hoffmann,Peter Hoffmann,Andreas Lun et al.
Christina Hoffmann et al.
Mannan-binding lectin (MBL) activates the lectin-complement pathway as part of the innate immune defence by binding to the surface of microorganisms. Therefore, MBL2 presents an interesting candidate gene for the inflammatory bowel diseases...
Comparative Study
Immunogenetics. 2010 Apr;62(4):231-5. DOI:10.1007/s00251-010-0429-0 2010
A revised leopard frog phylogeny allows a more detailed examination of adaptive evolution at ranatuerin-2 antimicrobial peptide loci [0.03%]
修订过的豹皮斑蛙系谱允许更详细地考察ranatuerin-2抗菌肽基因座适应性进化的情况
Jacob A Tennessen,Michael S Blouin
Jacob A Tennessen
Ranatuerins are antimicrobial peptides of the innate immune system found in ranid frogs. We previously presented evidence that a positive selective sweep had fixed a single allele at the Ranatuerin2 locus in the northern leopard frog (Rana ...
Evolutionary analysis of two classical MHC class I loci of the medaka fish, Oryzias latipes: haplotype-specific genomic diversity, locus-specific polymorphisms, and interlocus homogenization [0.03%]
刺身鱼两个经典MHCⅠ类基因座的进化分析：单体型特异性基因组多样性、位点特异性多态性及基因座之间的同质化
Mayumi I Nonaka,Masaru Nonaka
Mayumi I Nonaka
The major histocompatibility complex (MHC) region of the teleost medaka (Oryzias latipes) contains two classical class I loci, UAA and UBA, whereas most lower vertebrates possess or express a single locus. To elucidate the allelic diversifi...
Polymorphic SVA retrotransposons at four loci and their association with classical HLA class I alleles in Japanese, Caucasians and African Americans [0.03%]
日本、高加索人和非裔美国人四个位点的多态性SVA逆转录转座子及其与经典HLA-I类等位基因的相关性
Jerzy K Kulski,Atsuko Shigenari,Hidetoshi Inoko
Jerzy K Kulski
Polymorphic insertion frequencies of the retrotransposons known as the "SVA" elements were investigated at four loci in the MHC class I genomic region to determine their allele and haplotype frequencies and associations with the HLA-A, -B o...
Comparative Study
Immunogenetics. 2010 Apr;62(4):211-30. DOI:10.1007/s00251-010-0427-2 2010
Immunoglobulin heavy chain diversity in Pteropid bats: evidence for a diverse and highly specific antigen binding repertoire [0.03%]
果蝠免疫球蛋白多样性：具有高度特异性抗原结合谱系的证据
Michelle L Baker,Mary Tachedjian,Lin-Fa Wang
Michelle L Baker
Bats are the natural host reservoir for range of emerging and re-emerging viruses, many of which cause significant morbidity and mortality in other mammals, yet appear to result in no clinical consequences for bats. The ability of bats to c...
Rhesus macaque MHC class I molecules show differential subcellular localizations [0.03%]
恒河猴的MHC I类分子表现出不同的亚细胞定位
Cornelia Rosner,Philip H Kruse,Torben Lübke et al.
Cornelia Rosner et al.
The MHC class I gene family of rhesus macaques is characterised by considerable gene duplications. While a HLA-C-orthologous gene is absent, the Mamu-A and in particular the Mamu-B genes have expanded, giving rise to plastic haplotypes with...
Extensive DRB region diversity in cynomolgus macaques: recombination as a driving force [0.03%]
食蟹猴DRB区域的多样性分析：重组作为主要驱动力
Gaby G M Doxiadis,Nanine de Groot,Natasja G de Groot et al.
Gaby G M Doxiadis et al.
The DR region of primate species is generally complex and displays diversity concerning the number and combination of distinct types of DRB genes present per region configuration. A highly variable short tandem repeat (STR) present in intro...
Rebecca L Tallmadge,Julie A Campbell,Donald C Miller et al.
Rebecca L Tallmadge et al.
The genomic sequences of 15 horse major histocompatibility complex (MHC) class I genes and a collection of MHC class I homozygous horses of five different haplotypes were used to investigate the genomic structure and polymorphism of the equ...
Study of cynomolgus monkey (Macaca fascicularis) DRA polymorphism in four populations [0.03%]
四个人群食蟹猴DRA基因多态性研究
Alice Aarnink,Laurent Estrade,Pol-André Apoil et al.
Alice Aarnink et al.
To describe the polymorphism of the DRA gene in Macaca fascicularis, we have studied 141 animals either at cDNA level (78 animals from Mauritius, the Philippines, and Vietnam) or genomic level (63 animals from the Philippines, Indonesia, an...