Thomas Stranzl,Mette Voldby Larsen,Claus Lundegaard et al.
Thomas Stranzl et al.
Reliable predictions of immunogenic peptides are essential in rational vaccine design and can minimize the experimental effort needed to identify epitopes. In this work, we describe a pan-specific major histocompatibility complex (MHC) clas...
Comparative genomic analysis of mammalian NKG2D ligand family genes provides insights into their origin and evolution [0.03%]
哺乳动物NKG2D配体基因组分析揭示其起源和进化动力学
Mizuho Kondo,Takako Maruoka,Noriyuki Otsuka et al.
Mizuho Kondo et al.
NKG2D is a major activating receptor of natural killer cells. Its ligands are major histocompatibility complex (MHC) class I-like molecules whose expression is induced by cellular stresses such as infections and tumorigenesis. Humans have t...
Comparative Study
Immunogenetics. 2010 Jul;62(7):441-50. DOI:10.1007/s00251-010-0438-z 2010
Lineage pattern, trans-species polymorphism, and selection pressure among the major lineages of feline MHC-DRB peptide-binding region [0.03%]
猫科动物MHC-DRB结合肽区域的主要谱系的世系分化模式、跨物种多态性和选择压力
Kun Wei,Zhihe Zhang,Xiaofang Wang et al.
Kun Wei et al.
The long-term evolution of major histocompatibility complex (MHC) involves the birth-and-death process and independent divergence of loci during episodes punctuated by natural selection. Here, we investigated the molecular signatures of nat...
Genetic variations in the C epsilon mX domain of human membrane-bound IgE [0.03%]
人类膜型IgE的C_epsilon mX结构域中的基因多态性
Lei Wan,Jiun-Bo Chen,Hsih Hsin Chen et al.
Lei Wan et al.
The epsilon chain of membrane-bound IgE (mIgE) is expressed predominantly as a "long" isoform, containing an extra segment of 52 amino acid (a.a.) residues, referred to as C epsilon mX, between the CH4 domain and the C-terminal membrane-anc...
SNP/haplotype associations in cytokine and cytokine receptor genes and immunity to rubella vaccine [0.03%]
细胞因子和细胞因子受体基因中的单核苷酸多态性/单体型与麻疹疫苗免疫的关系
Neelam Dhiman,Iana H Haralambieva,Richard B Kennedy et al.
Neelam Dhiman et al.
An effective immune response to vaccination is, in part, a complex interaction of alleles of multiple genes regulating cytokine networks. We conducted a genotyping study of Th1/Th2/inflammatory cytokines/cytokine receptors in healthy childr...
Impact of female cigarette smoking on circulating B cells in vivo: the suppressed ICOSLG, TCF3, and VCAM1 gene functional network may inhibit normal cell function [0.03%]
吸烟对女性体内B淋巴细胞的影响：ICOSLG、TCF3和VCAM1基因功能网络受抑制可能导致细胞功能受损
Feng Pan,Tie-Lin Yang,Xiang-Ding Chen et al.
Feng Pan et al.
As pivotal immune guardians, B cells were found to be directly associated with the onset and development of many smoking-induced diseases. However, the in vivo molecular response of B cells underlying the female cigarette smoking remains un...
Randomized Controlled Trial
Immunogenetics. 2010 Apr;62(4):237-51. DOI:10.1007/s00251-010-0431-6 2010
Design and utilization of epitope-based databases and predictive tools [0.03%]
基于抗原表位的数据库和预测工具的设计及应用
Nima Salimi,Ward Fleri,Bjoern Peters et al.
Nima Salimi et al.
In the last decade, significant progress has been made in expanding the scope and depth of publicly available immunological databases and online analysis resources, which have become an integral part of the repertoire of tools available to ...
Short template amplicon and multiplex megaprimer-enabled relay (STAMMER) sequencing, a simultaneous approach to higher throughput sequence-based typing of polymorphic genes [0.03%]
短模板扩增和多路复用超长引物递送（STAMMER）测序，一种同时进行多态基因的序列分型的新方法
Chrissy H Roberts,Neema P Mayor,J Alejandro Madrigal et al.
Chrissy H Roberts et al.
Sequence-based typing (SBT) is a powerful method of genotyping in highly polymorphic gene systems. In standard SBT methods, both strands of a double-stranded template amplicon are sequenced in separate reactions in order to achieve high qua...
Jeroen H Blokhuis,Marit K van der Wiel,Gaby G M Doxiadis et al.
Jeroen H Blokhuis et al.
To further refine and improve biomedical research in rhesus macaques, it is necessary to increase our knowledge concerning both the degree of allelic variation (polymorphism) and diversity (gene copy number variation) in the killer cell imm...
Qing Zhang,Christian M Zmasek,Adam Godzik
Qing Zhang
In animals, the innate immune system is the first line of defense against invading microorganisms, and the pattern-recognition receptors (PRRs) are the key components of this system, detecting microbial invasion and initiating innate immune...