Chronic allergen challenge induces bronchial mast cell accumulation in BALB/c but not C57BL/6 mice and is independent of IL-9 [0.03%]
慢性过敏原刺激使BALB/c而非C57BL/6小鼠支气管组织中的肥大细胞聚集，且与IL-9无关
Suzan Pae,Jae Youn Cho,Shanna Dayan et al.
Suzan Pae et al.
As genetically engineered mutant mice deficient in single genes are usually generated on a C57BL/6 background, to study mast cell trafficking in mutant mice, we initially investigated whether mast cells accumulated in bronchi in C57BL/6 mic...
Comparative Study
Immunogenetics. 2010 Aug;62(8):499-506. DOI:10.1007/s00251-010-0452-1 2010
Haplotype variation, recombination, and gene conversion within the turkey MHC-B locus [0.03%]
火鸡MHC-B基因座的单倍型变异、重组和基因转换现象
Lee D Chaves,Gretchen M Faile,Stacy B Krueth et al.
Lee D Chaves et al.
The major histocompatibility complex (MHC) is a gene dense region with profound effects on the disease phenotype. In many species, characterizations of MHC polymorphisms have focused on identifying allelic haplotypes of the highly polymorph...
Colum McErlean,Asensio A Gonzalez,Rodat Cunningham et al.
Colum McErlean et al.
Allelic polymorphisms dramatically influence the phenotype of human killer immunoglobulin-like receptors (KIR) by modifying their expression in cell surfaces. It is unclear though to what extent this involves transcriptional or post-transcr...
Comparative Study
Immunogenetics. 2010 Jul;62(7):431-40. DOI:10.1007/s00251-010-0449-9 2010
Erratum to: rhesus macaque MHC class I molecules show differential subcellular localizations [0.03%]
致：恒河猴MHCⅠ分子显示不同的亚细胞定位
Cornelia Rosner,Philip H Kruse,Torben Lübke et al.
Cornelia Rosner et al.
The MHC class I gene family of rhesus macaques is characterised by considerable gene duplications. While a HLA-C-orthologous gene is absent, the Mamu-A and in particular the Mamu-B genes have expanded, giving rise to plastic haplotypes with...
Organization of the variable region of the immunoglobulin heavy-chain gene locus of the rat [0.03%]
大鼠免疫球蛋白重链基因位点可变区的组成
Jacobus Hendricks,Peter Terpstra,Peter M Dammers et al.
Jacobus Hendricks et al.
We have mapped and annotated the variable region of the immunoglobulin heavy (IGH) gene locus of the Brown Norway (BN) rat (assembly V3.4; Rat Genomic Sequence Consortium). In addition to known variable region genes, we found 12 novel previ...
Suppressive effects of transcription factor GATA-1 on cell type-specific gene expression in dendritic cells [0.03%]
转录因子GATA-1在树突状细胞中对细胞类型特异性基因表达的抑制作用
Naomi Shimokawa,Chiharu Nishiyama,Nobuhiro Nakano et al.
Naomi Shimokawa et al.
To evaluate the effects of the transcription factor GATA-1 on determining cell fate between dendritic cell (DC) and mast cell (MC) lineages, GATA-1 was exogenously expressed in bone marrow-derived (BM) DCs. Exogenous expression of GATA-1 by...
Comparative Study
Immunogenetics. 2010 Jul;62(7):421-9. DOI:10.1007/s00251-010-0444-1 2010
Comprehensive analysis and characterization of the TCR alpha chain sequences in the common marmoset [0.03%]
常见狨猴TCR alpha链序列的全面分析与表征
Yoshiki Fujii,Takaji Matsutani,Kazutaka Kitaura et al.
Yoshiki Fujii et al.
The common marmoset (Callithrix jacchus) is useful as a nonhuman primate model of human diseases. Although the marmoset model has great potential for studying autoimmune diseases and immune responses against pathogens, little information is...
Haplotypes of IL12B promoter polymorphisms condition susceptibility to severe malaria and functional changes in cytokine levels in Thai adults [0.03%]
泰国成人严重疟疾易感性的IL12B启动子多态性单倍型及其对细胞因子水平的功能改变
Chintana Phawong,Collins Ouma,Piyatida Tangteerawatana et al.
Chintana Phawong et al.
Polymorphic variability in immune response genes, such as IL12B, encoding the IL-12p40 subunit is associated with susceptibility to severe malaria in African populations. Since the role of genetic variation in conditioning severe malaria in...
A novel CD93 polymorphism in non-obese diabetic (NOD) and NZB/W F1 mice is linked to a CD4+ iNKT cell deficient state [0.03%]
非肥胖糖尿病(NOD)和NZB/W F1小鼠中CD93的新多态性与CD4+NKT细胞缺乏状态相关
Ghazal Zekavat,Raha Mozaffari,Vanessa J Arias et al.
Ghazal Zekavat et al.
In the present study, we characterize a polymorphism in the CD93 molecule, originally identified as the receptor for the C1q complement component (i.e., C1qRp, or AA4.1) in non-obese diabetic (NOD) mice. This allele carries a coding polymor...
High degree of conservation of the multigene tryptase locus over the past 150-200 million years of mammalian evolution [0.03%]
哺乳动物进化史上，长达一亿五千万至两亿年的肥大细胞多基因促胰液素结构的高稳定性
Jenny M Reimer,Paul B Samollow,Lars Hellman
Jenny M Reimer
Activated mast cells release a number of potent inflammatory mediators including histamine, proteoglycans, cytokines, and serine proteases. The proteases constitute the majority of the mast cell granule proteins, and they belong to either t...