The basis for haplotype complexity in VCBPs, an immune-type receptor in amphioxus [0.03%]
文昌鱼免疫型受体的单倍体型复杂性的基础
Larry J Dishaw,Tatsuya Ota,M Gail Mueller et al.
Larry J Dishaw et al.
Innate immune gene repertoires are restricted primarily to germline variation. Adaptive immunity, by comparison, relies on somatic variation of germline-encoded genes to generate extraordinarily large numbers of non-heritable antigen recogn...
Taeko K Naruse,Zhiyong Chen,Risa Yanagida et al.
Taeko K Naruse et al.
Rhesus macaques (Macaca mulatta) are widely used in developing a strategy for vaccination against human immunodeficiency virus by using simian immunodeficiency virus infection as a model system. Because the genome diversity of major histoco...
Comparative Study
Immunogenetics. 2010 Sep;62(9):601-11. DOI:10.1007/s00251-010-0462-z 2010
A molecule in teleost fish, related with human MHC-encoded G6F, has a cytoplasmic tail with ITAM and marks the surface of thrombocytes and in some fishes also of erythrocytes [0.03%]
在硬骨鱼中发现与人类MHC编码的G6F相关的含有ITAM基序胞浆尾部分子并可标记血小板和某些鱼类的红细胞
Ken Ohashi,Fumio Takizawa,Norihiro Tokumaru et al.
Ken Ohashi et al.
In teleost fish, a novel gene G6F-like was identified, encoding a type I transmembrane molecule with four extracellular Ig-like domains and a cytoplasmic tail with putative tyrosine phosphorylation motifs including YxN and an immunoreceptor...
Comparative Study
Immunogenetics. 2010 Aug;62(8):543-59. DOI:10.1007/s00251-010-0460-1 2010
The live-attenuated yellow fever vaccine 17D induces broad and potent T cell responses against several viral proteins in Indian rhesus macaques--implications for recombinant vaccine design [0.03%]
减毒黄热病毒株17D诱导了食蟹猕猴的多种抗原蛋白的广谱强力T细胞反应：对重组疫苗设计的意义
Philip A Mudd,Shari M Piaskowski,Patricia C Costa Neves et al.
Philip A Mudd et al.
The yellow fever vaccine 17D (YF17D) is one of the most effective vaccines. Its wide use and favorable safety profile make it a prime candidate for recombinant vaccines. It is believed that neutralizing antibodies account for a large measur...
Thirty allele-level haplotypes centered around KIR2DL5 define the diversity in an African American population [0.03%]
以KIR2DL5为中心的30个等位基因型单体型定义了非洲裔美国人种群的多样性
Lihua Hou,Minghua Chen,Bo Jiang et al.
Lihua Hou et al.
KIR2DL5 alleles were physically linked to alleles at adjacent KIR loci to define this region of KIR haplotypes in 55 gene-positive random African Americans. The majority carried KIR2DL5B. Three KIR2DL5A and six KIR2DL5B alleles that have be...
Copy number variation and association over T-cell receptor genes--influence of DNA source [0.03%]
基于DNA来源的T细胞受体基因拷贝数变异及其连锁不平衡的影响
Christine Schwienbacher,Alessandro De Grandi,Christian Fuchsberger et al.
Christine Schwienbacher et al.
Genomic copy number variants (CNVs) are a common, heritable source of inter-individual differences in genomic sequence. Their influence on phenotypic variability and their involvement in the pathogenesis of several common diseases is well e...
Vkappa polymorphisms in NOD mice are spread throughout the entire immunoglobulin kappa locus and are shared by other autoimmune strains [0.03%]
NOD小鼠Igκ基因座的Vkappa多态性及其在其他自身免疫品系中的共享性研究
Rachel A Henry,Peggy L Kendall,Emily J Woodward et al.
Rachel A Henry et al.
The diversity of immunoglobulin (Ig) and T cell receptor (TCR) genes available to form the lymphocyte repertoire has the capacity to produce a broad array of both protective and harmful specificities. In type 1 diabetes (T1D), the presence ...
The complete inventory of receptors encoded by the rat natural killer cell gene complex [0.03%]
大鼠自然杀伤细胞基因簇所编码受体的完整库存表
Line M Flornes,Øyvind Nylenna,Per C Saether et al.
Line M Flornes et al.
The natural killer cell gene complex (NKC) encodes receptors belonging to the C-type lectin superfamily expressed primarily by NK cells and other leukocytes. In the rat, the chromosomal region that starts with the Nkrp1a locus and ends with...
MHC evolution in three salmonid species: a comparison between class II alpha and beta genes [0.03%]
三种鲑科鱼类MHC进化：I类α基因与β基因的比较
Daniela Gómez,Pablo Conejeros,Sergio H Marshall et al.
Daniela Gómez et al.
The genes of the major histocompatibility complex (MHC) are amongst the most variable in vertebrates and represent some of the best candidates to study processes of adaptive evolution. However, despite the number of studies available, most ...
Comparative Study
Immunogenetics. 2010 Aug;62(8):531-42. DOI:10.1007/s00251-010-0456-x 2010
The most common Chinese rhesus macaque MHC class I molecule shares peptide binding repertoire with the HLA-B7 supertype [0.03%]
中国最常见的一种猕猴MHCⅠ类分子与人类白细胞抗原B7超型的多肽结合谱相似
Christopher Solomon,Scott Southwood,Ilka Hoof et al.
Christopher Solomon et al.
Of the two rhesus macaque subspecies used for AIDS studies, the Simian immunodeficiency virus-infected Indian rhesus macaque (Macaca mulatta) is the most established model of HIV infection, providing both insight into pathogenesis and a sys...
Comparative Study
Immunogenetics. 2010 Jul;62(7):451-64. DOI:10.1007/s00251-010-0450-3 2010