Comparative analysis of mutation of tyrosine kinase kit in mast cells from patients with systemic mast cell activation syndrome and healthy subjects [0.03%]
系统性肥大细胞活化综合征患者与健康对照者肥大细胞KIT酪氨酸激酶突变的比较分析
Gerhard J Molderings,Kirsten Meis,Ulrich W Kolck et al.
Gerhard J Molderings et al.
Systemic mast cell activation syndrome is a mast cell disorder characterized by an unregulated increased activation of mast cells leading to a pathologically enhanced release of mediators. Mutations in tyrosine kinase kit which crucially de...
MHC class I and MHC class II DRB gene variability in wild and captive Bengal tigers (Panthera tigris tigris) [0.03%]
孟加拉虎（ Panthera tigris tigris ）的 MHC-I 和 MHC-II DRB 基因变异性的多样性：圈养和野生群体比较研究
Ina Pokorny,Reeta Sharma,Surendra Prakash Goyal et al.
Ina Pokorny et al.
Bengal tigers are highly endangered and knowledge on adaptive genetic variation can be essential for efficient conservation and management. Here we present the first assessment of allelic variation in major histocompatibility complex (MHC) ...
Comparative Study
Immunogenetics. 2010 Oct;62(10):667-79. DOI:10.1007/s00251-010-0475-7 2010
Comparative analysis of nonaspanin protein sequences and expression studies in zebrafish [0.03%]
斑马鱼非锚定蛋白序列比较分析及表达研究
Benoist Pruvot,Véronique Laurens,Françoise Salvadori et al.
Benoist Pruvot et al.
Nonaspanins constitute a family of proteins, also called TM9SF, characterized by a large non-cytoplasmic domain and nine putative transmembrane domains. This family is highly conserved through evolution and comprises three members in Saccha...
Comparative Study
Immunogenetics. 2010 Oct;62(10):681-99. DOI:10.1007/s00251-010-0472-x 2010
Simian immunodeficiency virus-specific CD4+ T cells from successful vaccinees target the SIV Gag capsid [0.03%]
成功接种疫苗的人的免疫缺陷病毒特异性CD4+T细胞 targeting SIV Gag Capsid
Juan P Giraldo-Vela,Alex T Bean,Richard Rudersdorf et al.
Juan P Giraldo-Vela et al.
We recently demonstrated that vaccinated rhesus macaques controlled viral replication of a heterologous SIV challenge. Here, we analyzed anamnestic SIV-specific CD4+ T-cell responses expanding immediately after challenge and show that succe...
DH and JH usage in murine fetal liver mirrors that of human fetal liver [0.03%]
DH和JH在小鼠胎儿肝脏中的使用情况与人类胎儿肝脏相似
Robert L Schelonka,Ewa Szymanska,Andre M Vale et al.
Robert L Schelonka et al.
In mouse and human, the regulated development of antibody repertoire diversity during ontogeny proceeds in parallel with the development of the ability to generate antibodies to an array of specific antigens. Compared to adult, the human fe...
Comparative Study
Immunogenetics. 2010 Oct;62(10):653-66. DOI:10.1007/s00251-010-0469-5 2010
Development of a DNA microarray for detection of expressed equine classical MHC class I sequences in a defined population [0.03%]
一种用于检测定义马种中表达的经典MHC-I类序列的DNA微阵列的发展
Joshua D Ramsay,Steven R Leib,Lisa Orfe et al.
Joshua D Ramsay et al.
Development of an accurate and efficient molecular-based equine MHC class I typing method would facilitate the study of T lymphocyte immune responses in horses. Here, a DNA microarray was designed to detect expressed classical MHC class I g...
Genomic architecture of MHC-linked odorant receptor gene repertoires among 16 vertebrate species [0.03%]
与16种脊椎动物MHC相联系的嗅觉受体基因亚组的基因组结构
Pablo Sandro Carvalho Santos,Thomas Kellermann,Barbara Uchanska-Ziegler et al.
Pablo Sandro Carvalho Santos et al.
The recent sequencing and assembly of the genomes of different organisms have shown that almost all vertebrates studied in detail so far have one or more clusters of genes encoding odorant receptors (OR) in close physical linkage to the maj...
Inhibition of type 1 diabetes by upregulation of the circadian rhythm-related aryl hydrocarbon receptor nuclear translocator-like 2 [0.03%]
通过上调与昼夜节律相关的AhR核转运子样蛋白2抑制1型糖尿病
Chen-Xia He,Nicolas Prevot,Christian Boitard et al.
Chen-Xia He et al.
The genetic locus Idd6 is involved in type 1 diabetes development in the non-obese diabetic (NOD) mouse through its effect on the immune system and in particular, on T cell activities. Analysis of congenic strains for Idd6 has established t...
Jennifer May-Ling Tjon,Jeroen van Bergen,Frits Koning
Jennifer May-Ling Tjon
In the small intestine of celiac disease patients, dietary wheat gluten and similar proteins in barley and rye trigger an inflammatory response. While strict adherence to a gluten-free diet induces full recovery in most patients, a small pe...
Characterisation of MHC class II DRB genes in the northern tree shrew (Tupaia belangeri) [0.03%]
北方树鼩MHC类II型DRB基因的特征分析
Claus Oppelt,Rebecca Wutzler,Dietrich von Holst
Claus Oppelt
Genes of the major histocompatibility complex (MHC) mainly code for proteins of the immune system of jawed vertebrates. In particular, MHC class I and II cell surface proteins are crucial for the self/non-self discrimination of the adaptive...