Association of toll-like receptor four single nucleotide polymorphisms with incidence of infectious bovine keratoconjunctivitis (IBK) in cattle [0.03%]
牛TLR4基因多态性与感染性角结膜炎易感性的关联分析
Ranjit S Kataria,Richard G Tait Jr,Dinesh Kumar et al.
Ranjit S Kataria et al.
Toll-like receptor 4 (TLR4) is a receptor protein that binds pathogen ligands, which are mainly associated with Gram-negative bacteria. The objective of this study was to investigate the association of nucleotide polymorphisms in TLR4 with ...
Sequence analysis of the grey mouse lemur (Microcebus murinus) MHC class II DQ and DR region [0.03%]
灰色鼠标狐猴(Microcebus murinus) MHC II类DQ和DR区域的序列分析
Anne Averdam,Christiane Kuschal,Nicole Otto et al.
Anne Averdam et al.
We here report the genomic organisation of the grey mouse lemur (Microcebus murinus) MHC class II DQ and DR region based on BAC clone analysis. The sequenced Mimu-MHC haplotype spans 343 kb and encompasses the genes TAP2, DOB, DQB, DQA, DRB...
MHC class II DRB diversity in raccoons (Procyon lotor) reveals associations with raccoon rabies virus (Lyssavirus) [0.03%]
灵猫科动物（Procyon lotor）II类主要组织相容性复合体DRB多样性与灵猫科狂犬病病毒（丽莎病毒）的相关性研究
Vythegi Srithayakumar,Sarrah Castillo,Rick C Rosatte et al.
Vythegi Srithayakumar et al.
In North America, the raccoon rabies virus (RRV) is an endemic wildlife disease which causes acute encephalopathies and is a strong selective force on raccoons (Procyon lotor), with estimates of ∼85% of the population succumbing to the dis...
Characterization of Mauritian cynomolgus macaque major histocompatibility complex class I haplotypes by high-resolution pyrosequencing [0.03%]
高分辨率 Pyro 序列分析法表征毛里求斯猕猴的大分子遗传复合体类 I 次型多态性
Melisa L Budde,Roger W Wiseman,Julie A Karl et al.
Melisa L Budde et al.
Major histocompatibility complex (MHC) class I alleles of nonhuman primates have been associated with disease susceptibility, resistance, and resolution. Here, using high-resolution pyrosequencing, we characterized MHC class I transcripts e...
Linkage disequilibrium organization of the human KIR superlocus: implications for KIR data analyses [0.03%]
人类KIR超级基因座的连锁不平衡结构及其对KIR数据分析的影响
Pierre-Antoine Gourraud,Ashley Meenagh,Anne Cambon-Thomsen et al.
Pierre-Antoine Gourraud et al.
An extensive family-based study of linkage disequilibrium (LD) in the killer cell immunoglobulin-like receptors (KIR) cluster was performed. We aimed to describe the LD structure in the KIR gene cluster using a sample of 418 founder haploty...
Association of KIR2DS1 and KIR2DS3 with fatal outcome in Ebola virus infection [0.03%]
KIR2DS1和KIR2DS3与埃博拉病毒感染致死结局相关性研究
Nadia Wauquier,Cindy Padilla,Pierre Becquart et al.
Nadia Wauquier et al.
Zaïre ebolavirus (ZEBOV) infection rapidly outruns the host's immunity and leads to death within a week. Fatal cases have been associated with an aberrant innate, proinflammatory immune response followed by a suppressed adaptive response l...
Origin and diversification of the L-amino oxidase family in innate immune defenses of animals [0.03%]
动物先天免疫防御中的L-氨基酸氧化酶家族的起源和多样化
Austin L Hughes
Austin L Hughes
L-amino acid oxidases (LAOs), because they produce hydrogen peroxide as a by-product, function in innate immune defenses of both vertebrates and mollusks. Phylogenetic analysis revealed two major subfamilies of LAOs: (1) a subfamily includi...
HLA-Cw group 1 ligands for KIR increase susceptibility to invasive cervical cancer [0.03%]
人类白细胞抗原-Cw组1的KIR配体增加侵袭性宫颈癌的易感性
Maureen P Martin,Ingrid B Borecki,Zhengyan Zhang et al.
Maureen P Martin et al.
Inherited genetic polymorphisms within immune response genes have been shown to associate with risk of invasive cervical cancer (ICC) and its immediate precursor, cervical intraepithelial neoplasia grade 3. Here, we used the transmission/di...
Selection, trans-species polymorphism, and locus identification of major histocompatibility complex class IIβ alleles of New World ranid frogs [0.03%]
新世界蛙类主要组织相容性复合体IIβ等位基因的选择、跨物种多态性和基因定位
Karen M Kiemnec-Tyburczy,Jonathan Q Richmond,Anna E Savage et al.
Karen M Kiemnec-Tyburczy et al.
Genes encoded by the major histocompatibility complex (MHC) play key roles in the vertebrate immune system. However, our understanding of the evolutionary processes and underlying genetic mechanisms shaping these genes is limited in many ta...
Ana Belén García-Ruano,Rosa Méndez,José María Romero et al.
Ana Belén García-Ruano et al.
We developed a novel human leukocyte antigen HLA-ABC locus-specific quantitative real-time polymerase chain reaction (PCR) to determine the locus-specific gene expression of HLA-ABC in peripheral blood leukocytes (PBLs, n = 53), colon mucos...