The KIR2DL1 intermediate upstream element participates in gene activation [0.03%]
KIR2DL1中间上游元件参与基因激活
Paul W Wright,Hongchuan Li,Md Ahasanur Rahman et al.
Paul W Wright et al.
The human KIR genes encode a family of class I MHC receptors that are expressed on subsets of NK cells. The expression of KIR proteins is controlled by a stochastic process, and competition between sense and antisense promoter elements has ...
Comparative genomics of the T cell receptor μ locus in marsupials and monotremes [0.03%]
有袋类和单孔类胎盘T细胞受体μ基因位点的比较基因组学研究
K A Morrissey,M R Stammnitz,E Murchison et al.
K A Morrissey et al.
T cells are a primary component of the vertebrate adaptive immune system. There are three mammalian T cell lineages based on their T cell receptors (TCR). The αβ T cells and γδ T cells are ancient and found broadly in vertebrates. The m...
Morgan E Janes,Allison Kinlein,Martin F Flajnik et al.
Morgan E Janes et al.
NKp30 is an activating natural killer cell receptor (NKR) with a single-exon variable (VJ)-type immunoglobulin superfamily (IgSF) domain. Such VJ-IgSF domains predate the emergence of the antigen receptors (immunoglobulin and T cell recepto...
Correlation between human leukocyte antigen ligands and killer cell immunoglobulin-like receptors in aplastic anemia patients from Shaanxi Han [0.03%]
汉族陕西籍再障患者HLA配体与杀伤细胞免疫球蛋白样受体相关性分析
Tianju Wang,Jun Qi,Manni Wang et al.
Tianju Wang et al.
Regulating natural killer (NK) cell responses in hematological malignancies largely depend on molecular interactions between killer cell immunoglobulin-like receptors (KIR) and human leukocyte antigen (HLA) class I ligands. The goal of the ...
Ancient fish lineages illuminate toll-like receptor diversification in early vertebrate evolution [0.03%]
古代鱼类谱系揭示了早期脊椎动物进化中 Toll 样受体的多样化发展
Kara B Carlson,Cameron Nguyen,Dustin J Wcisel et al.
Kara B Carlson et al.
Since its initial discovery over 50 years ago, understanding the evolution of the vertebrate RAG- mediated adaptive immune response has been a major area of research focus for comparative geneticists. However, how the evolutionary novelty o...
Increased circulating Th17 cell populations in patients with pancreatic ductal adenocarcinoma [0.03%]
胰腺导管腺癌患者循环中的Th17细胞群增加
Imteyaz Ahmad Khan,Nidhi Singh,Deepak Gunjan et al.
Imteyaz Ahmad Khan et al.
T-helper 17 (Th17) cells are a subset of CD4+ helper T cells that produce interleukin 17 (IL-17) and play a crucial role in the pathogenesis of inflammatory and autoimmune diseases. Few studies have been conducted to determine the role of T...
Ronald Bontrop,Martin Flajnik,Colm S O&#x;Huigin et al.
Ronald Bontrop et al.
Factors regulating the differences in frequency of infiltration of Th17 and Treg of the blood-brain barrier [0.03%]
调控血脑屏障中Th17和Treg细胞浸润频率差异的因素
Norwin Kubick,Marzena Lazarczyk,Nina Strzałkowska et al.
Norwin Kubick et al.
Controlling CD4+ immune cell infiltration of the brain is a leading aim in designing therapeutic strategies for a range of neuropathological disorders such as multiple sclerosis, Alzheimer's disease, and depression. CD4+ T cells are a highl...
The minor chicken class I gene BF1 is deleted between short imperfect direct repeats in the B14 and typical B15 major histocompatibility complex (MHC) haplotypes [0.03%]
鸡类I基因BF1在B14和典型的B15主要组织相容性复合体(MHC)染色体类型之间被短的不完美的直接重复序列删除
Nicolas I E Rocos,Felicity J Coulter,Thomas C J Tan et al.
Nicolas I E Rocos et al.
The chicken major histocompatibility complex (MHC, also known as the BF-BL region of the B locus) is notably small and simple with few genes, most of which are involved in antigen processing and presentation. There are two classical class I...
Dysregulated PD-L2 is correlated with disease activity and inflammation in rheumatoid arthritis [0.03%]
PD-L2调控失常与类风湿性关节炎的疾病活动及炎症正相关关系
Jian Xiong,Jie Yang,Yuling Sun et al.
Jian Xiong et al.
The programmed death-1 (PD-1) pathway has been shown to deliver an inhibitory signal, and aberrant expression of the PD-1 molecule and/or its ligand programmed death ligand 1 (PD-L1) has been demonstrated in human diseases, while its other ...