Regulation of genes involved in the metabolic adaptation of murine microglial cells in response to elevated HIF-1α mediated activation [0.03%]
高HIF-1α介导的激活对小鼠小胶质细胞代谢适应相关基因表达的调控研究
Ida Florance,Seenivasan Ramasubbu
Ida Florance
Microglia cells are activated in response to different stress signals. Several metabolic adaptations underlie microglia activation in the brain. Among these, in conditions like ischemic stroke and, hypoxic stress stimuli activate microglia ...
Determination for KIR genotype and allele copy number via real-time quantitative PCR method [0.03%]
实时定量PCR法确定KIR基因型和等位基因拷贝数
Sudan Tao,Xuan You,Jielin Wang et al.
Sudan Tao et al.
Killer cell immunoglobulin-like receptor (KIR) and human leukocyte antigen (HLA) play crucial roles in regulating NK cell activity. Here, we report a real-time quantitative PCR (qPCR) to genotype all KIR genes and their copy numbers simulta...
Costimulatory receptors in the channel catfish: CD28 family members and their ligands [0.03%]
沟鲶的共刺激受体：CD28家族成员及其配体
Sylvie M A Quiniou,Eva Bengtén,Pierre Boudinot
Sylvie M A Quiniou
The CD28-B7 interaction is required to deliver a second signal necessary for T-cell activation. Additional membrane receptors of the CD28 and B7 families are also involved in immune checkpoints that positively or negatively regulate leukocy...
The impact of long COVID on health-related quality of life in patients 6 months after discharge with severe COVID-19 [0.03%]
长程COVID对出院6个月后严重COVID-19患者生活质量的影响
Seyedeh Mahdieh Namayandeh,Moslem Basti,Sara Jambarsang et al.
Seyedeh Mahdieh Namayandeh et al.
This study investigates the relationship between long COVID and health-related quality of life (HRQOL) in patients discharged for 6 months. It included 192 patients with a history of severe COVID-19 and 192 patients with a history of non-se...
Patterns of evolution in MHC class II DQA and DQB exon 2 genes of Alpine mountain hares, Lepus timidus varronis, and sympatric and parapatric brown hares, L. europaeus, from Switzerland [0.03%]
来自瑞士阿尔卑斯地区的山兔（Lepus timidus varronis）和同域及近域分布的褐兔（L. europaeus）DQA和DQB基因第2外显子中MHC II类分子的演化模式
A Awadi,H Ben Slimen,S Smith et al.
A Awadi et al.
In natural populations, hybridization is known to occur between a wide range of species. However, its evolutionary significance is less clear. Genes involved in fighting pathogens are considered excellent candidates for studying adaptive in...
Samuel Stróż,Piotr Kosiorek,Anna Stasiak-Barmuta
Samuel Stróż
The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lasted from March 2020 to May 2023, infecting over 689 million and causing 6.9 million deaths globally. SARS-CoV-2 enters human cells via the spike...
A novel missense mutation in the AIRE gene underlying autoimmune polyglandular syndrome type 1 [0.03%]
AIRE基因错义突变导致的一型自身免疫性多腺体综合征病例报道
Susana Vitozzi,Silvia Graciela Correa,Alejandro Lozano et al.
Susana Vitozzi et al.
The immune regulator gene AIRE plays an essential role in the establishment of immune tolerance and the prevention of autoimmunity. This transcription factor plays a critical role in promoting self-tolerance in the thymus by regulating the ...
Investigating associations between HLA DQA1 ~ DQB1 haplotypes, H. pylori infection, metaplasia, and anti-CagA IgA seropositivity in a Turkish gastritis cohort [0.03%]
在一组土耳其胃炎患者中研究HLA-DQA1~DQB1单倍型、幽门螺旋杆菌感染、不典型增生和抗CagA-IgA阳性之间的关联
Mukaddes Colakogullari,Lokman Karatas,Zeynep Tatar
Mukaddes Colakogullari
Helicobacter pylori was reported as an important cause of gastritis, and gastric ulcers and CagA oncoprotein-producing H. pylori subgroups were blamed to increase the severity of gastritis. Disparities were reported in that the presence of ...
Immunogenetics, sylvatic plague and its vectors: insights from the pathogen reservoir Mastomys natalensis in Tanzania [0.03%]
免疫遗传学、丛林鼠疫及其传播媒介：来自坦桑尼亚病原体库的洞穴老鼠Mastomys natalensis的新见解
Lavinia Haikukutu,Japhet R Lyaku,Charles M Lyimo et al.
Lavinia Haikukutu et al.
Yersinia pestis is a historically important vector-borne pathogen causing plague in humans and other mammals. Contemporary zoonotic infections with Y. pestis still occur in sub-Saharan Africa, including Tanzania and Madagascar, but receive ...
Macroevolution of avian T cell receptor C segments using genomic data [0.03%]
利用基因组数据研究鸟类T细胞受体C区段的宏进化
Chunhong Liang,Lin Sun,Ying Zhu et al.
Chunhong Liang et al.
All jawed vertebrates have four T cell receptor (TCR) chains expressed by thymus-derived lymphocytes that play a significant role in animal immune defense. However, avian TCR studies have been limited to a few species, although their co-fun...