Causal effect of interleukin (IL)-6 on blood pressure and hypertension: A mendelian randomization study [0.03%]
白细胞介素（IL）-6对血压和高血压的因果效应：一项孟德尔随机化研究
Ou Wu,Ya Wu,Xingyu Zhang et al.
Ou Wu et al.
To examine whether circulating interleukin-6 (IL-6) levels (CirIL6) have a causal effect on blood pressure using Mendelian randomization (MR) methods. We used data from genome-wide association studies (GWAS) of European ancestry to obtain g...
Resolving unknown nucleotides in the IPD-IMGT/HLA database by extended and full-length sequencing of HLA class I and II alleles [0.03%]
通过扩展和全长测序解决IPD-IMGT/HLA数据库中I类和II类等位基因的未知核苷酸
Christina E M Voorter,Mathijs Groeneweg,Timo I Olieslagers et al.
Christina E M Voorter et al.
In the past, identification of HLA alleles was limited to sequencing the region of the gene coding for the peptide binding groove, resulting in a lack of sequence information in the HLA database, challenging HLA allele assignment software p...
Concise review: The heterogenous roles of BATF3 in cancer oncogenesis and dendritic cells and T cells differentiation and function considering the importance of BATF3-dependent dendritic cells [0.03%]
综述：BATF3在肿瘤发生和树突状细胞以及T细胞的分化与功能中异质性作用概述——强调依赖于BATF3的树突状细胞的重要性
Reza Dabbaghipour,Elham Ahmadi,Mona Entezam et al.
Reza Dabbaghipour et al.
The transcription factor, known as basic leucine zipper ATF-like 3 (BATF3), is a crucial contributor to the development of conventional type 1 dendritic cells (cDC1), which is definitely required for priming CD8 + T cell-mediated immunity a...
Regulation of genes involved in the metabolic adaptation of murine microglial cells in response to elevated HIF-1α mediated activation [0.03%]
高HIF-1α介导的激活对小鼠小胶质细胞代谢适应相关基因表达的调控研究
Ida Florance,Seenivasan Ramasubbu
Ida Florance
Microglia cells are activated in response to different stress signals. Several metabolic adaptations underlie microglia activation in the brain. Among these, in conditions like ischemic stroke and, hypoxic stress stimuli activate microglia ...
Determination for KIR genotype and allele copy number via real-time quantitative PCR method [0.03%]
实时定量PCR法确定KIR基因型和等位基因拷贝数
Sudan Tao,Xuan You,Jielin Wang et al.
Sudan Tao et al.
Killer cell immunoglobulin-like receptor (KIR) and human leukocyte antigen (HLA) play crucial roles in regulating NK cell activity. Here, we report a real-time quantitative PCR (qPCR) to genotype all KIR genes and their copy numbers simulta...
Costimulatory receptors in the channel catfish: CD28 family members and their ligands [0.03%]
沟鲶的共刺激受体：CD28家族成员及其配体
Sylvie M A Quiniou,Eva Bengtén,Pierre Boudinot
Sylvie M A Quiniou
The CD28-B7 interaction is required to deliver a second signal necessary for T-cell activation. Additional membrane receptors of the CD28 and B7 families are also involved in immune checkpoints that positively or negatively regulate leukocy...
The impact of long COVID on health-related quality of life in patients 6 months after discharge with severe COVID-19 [0.03%]
长程COVID对出院6个月后严重COVID-19患者生活质量的影响
Seyedeh Mahdieh Namayandeh,Moslem Basti,Sara Jambarsang et al.
Seyedeh Mahdieh Namayandeh et al.
This study investigates the relationship between long COVID and health-related quality of life (HRQOL) in patients discharged for 6 months. It included 192 patients with a history of severe COVID-19 and 192 patients with a history of non-se...
Patterns of evolution in MHC class II DQA and DQB exon 2 genes of Alpine mountain hares, Lepus timidus varronis, and sympatric and parapatric brown hares, L. europaeus, from Switzerland [0.03%]
来自瑞士阿尔卑斯地区的山兔（Lepus timidus varronis）和同域及近域分布的褐兔（L. europaeus）DQA和DQB基因第2外显子中MHC II类分子的演化模式
A Awadi,H Ben Slimen,S Smith et al.
A Awadi et al.
In natural populations, hybridization is known to occur between a wide range of species. However, its evolutionary significance is less clear. Genes involved in fighting pathogens are considered excellent candidates for studying adaptive in...
Samuel Stróż,Piotr Kosiorek,Anna Stasiak-Barmuta
Samuel Stróż
The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lasted from March 2020 to May 2023, infecting over 689 million and causing 6.9 million deaths globally. SARS-CoV-2 enters human cells via the spike...
A novel missense mutation in the AIRE gene underlying autoimmune polyglandular syndrome type 1 [0.03%]
AIRE基因错义突变导致的一型自身免疫性多腺体综合征病例报道
Susana Vitozzi,Silvia Graciela Correa,Alejandro Lozano et al.
Susana Vitozzi et al.
The immune regulator gene AIRE plays an essential role in the establishment of immune tolerance and the prevention of autoimmunity. This transcription factor plays a critical role in promoting self-tolerance in the thymus by regulating the ...