B-cells absence in patients diagnosed as inborn errors of immunity: a registry-based study [0.03%]
基于注册表的先天性免疫缺陷患者B细胞缺如特征分析
Razieh Khoshnevisan,Shakiba Hassanzadeh,Christoph Klein et al.
Razieh Khoshnevisan et al.
Hypogammaglobulinemia without B-cells is a subgroup of inborn errors of immunity (IEI) which is characterized by a significant decline in all serum immunoglobulin isotypes, coupled with a pronounced reduction or absence of B-cells. Approxim...
Determination of HLA class II risk alleles and prediction of self/non-self-epitopes contributing Hashimoto's thyroiditis in a group of Iranian patients [0.03%]
伊朗一组桥本甲状腺炎患者HLAⅡ类危险等位基因的确定及自身/非自身表位预测
Ata Shirizadeh,Shiva Borzouei,Zahra Razavi et al.
Ata Shirizadeh et al.
One of the probable hypotheses for the onset of autoimmunity is molecular mimicry. This study aimed to determine the HLA-II risk alleles for developing Hashimoto's thyroiditis (HT) in order to analyze the molecular homology between candidat...
Daniel Vázquez-Coto,Christine Kimball,Guillermo M Albaiceta et al.
Daniel Vázquez-Coto et al.
There is tremendous interindividual and interracial variability in the outcome of SARS-CoV-2 infection, suggesting the involvement of host genetic factors. Here, we investigated whether IgG allotypes GM (γ marker) 3 and GM 17, genetic mark...
A novel hemizygous CD40L mutation of X-linked hyper IgM syndromes and compound heterozygous DOCK8 mutations of hyper IgE syndromes in two Chinese families [0.03%]
两个中国家庭中X连锁高IgM综合征的新型CD40L半合子突变和高IgE综合征的DOCK8复合杂合子突变
Mingzhen Guo,Yuanxuan Ma,Kangxi Cai et al.
Mingzhen Guo et al.
X-linked hyper-immunoglobulin M (X-HIGM) syndrome and autosomal recessive hyper-immunoglobulin E syndrome (HIES) are rare inborn errors of immunity characterized by recurrent infections due to immune system impairment. In this study, we ide...
Case Reports
Immunogenetics. 2024 Jun;76(3):165-173. DOI:10.1007/s00251-024-01340-0 2024
HLA class I NK-epitopes and KIR diversities in patients with multiple myeloma [0.03%]
多发性骨髓瘤患者的I类人白细胞抗原NK表位和KIR多样性
Nicky A Beelen,Stefan J J Molenbroeck,Lisette Groeneveld et al.
Nicky A Beelen et al.
Multiple myeloma (MM) is a hematological malignancy caused by the clonal expansion of malignant plasma cells in the bone marrow. Myeloma cells are susceptible to killing by natural killer (NK) cells, but NK cells fail to control disease pro...
Lack of Syndecan-1 promotes the pathogenesis of experimental rheumatoid arthritis [0.03%]
Syndecan-1的缺乏促进实验性类风湿关节炎的发生和发展
Rosalyn Jurjus,Laura Dosh,Rima Farhat et al.
Rosalyn Jurjus et al.
Syndecan-1 (Sdc-1), a transmembrane heparan sulfate protein, is implicated in several pathophysiological processes including rheumatoid arthritis (RA). The exact role of Syndican-1 in this autoimmune disease is still undetermined. This stud...
Evolutionary divergence of TLR9 through ancestral sequence reconstruction [0.03%]
通过祖先序列重构分析TLR9的进化分歧
Manisha Ghosh,Surajit Basak,Shanta Dutta
Manisha Ghosh
The transmembrane pattern recognition receptor, Toll-like receptor (TLR), are best known for their roles in innate immunity via recognition of pathogen and initiation of signaling response. Mammalian TLRs recognize molecular patterns associ...
Causal effect of interleukin (IL)-6 on blood pressure and hypertension: A mendelian randomization study [0.03%]
白细胞介素（IL）-6对血压和高血压的因果效应：一项孟德尔随机化研究
Ou Wu,Ya Wu,Xingyu Zhang et al.
Ou Wu et al.
To examine whether circulating interleukin-6 (IL-6) levels (CirIL6) have a causal effect on blood pressure using Mendelian randomization (MR) methods. We used data from genome-wide association studies (GWAS) of European ancestry to obtain g...
Resolving unknown nucleotides in the IPD-IMGT/HLA database by extended and full-length sequencing of HLA class I and II alleles [0.03%]
通过扩展和全长测序解决IPD-IMGT/HLA数据库中I类和II类等位基因的未知核苷酸
Christina E M Voorter,Mathijs Groeneweg,Timo I Olieslagers et al.
Christina E M Voorter et al.
In the past, identification of HLA alleles was limited to sequencing the region of the gene coding for the peptide binding groove, resulting in a lack of sequence information in the HLA database, challenging HLA allele assignment software p...
Concise review: The heterogenous roles of BATF3 in cancer oncogenesis and dendritic cells and T cells differentiation and function considering the importance of BATF3-dependent dendritic cells [0.03%]
综述：BATF3在肿瘤发生和树突状细胞以及T细胞的分化与功能中异质性作用概述——强调依赖于BATF3的树突状细胞的重要性
Reza Dabbaghipour,Elham Ahmadi,Mona Entezam et al.
Reza Dabbaghipour et al.
The transcription factor, known as basic leucine zipper ATF-like 3 (BATF3), is a crucial contributor to the development of conventional type 1 dendritic cells (cDC1), which is definitely required for priming CD8 + T cell-mediated immunity a...