Associations between immune cell traits and autoimmune thyroid diseases: a bidirectional two-sample mendelian randomization study [0.03%]
免疫细胞特性与自身免疫性甲状腺疾病之间的关联：双向两样本孟德尔随机化研究
ZheXu Cao,JiangSheng Huang,Xia Long
ZheXu Cao
Autoimmune thyroid diseases (AITDs), mainly including Graves' disease (GD) and Hashimoto's thyroiditis (HT), are common autoimmune disorders characterized by abnormal immune responses targeting the thyroid gland. We conducted a bidirectiona...
Dog leukocyte antigen genotyping across class I and class II genes in beagle dogs as laboratory animals [0.03%]
利用试验用比格犬进行犬白细胞抗原经典I类和II类等位基因的分型研究
Hiroya Konno,Jiro Miyamae,Hiroko Kataoka et al.
Hiroya Konno et al.
Dog leukocyte antigen (DLA) polymorphisms have been found to be associated with inter-individual variations in the risk, susceptibility, and severity of immune-related phenomena. While DLA class II genes have been extensively studied, less ...
HLA alleles, haplotypes frequencies, and their association with hematological disorders: a report from 1550 families whose patients underwent allogeneic bone marrow transplantation in Egypt [0.03%]
埃及1550个接受异基因骨髓移植的家庭的人类白细胞抗原等位基因、单倍型频率及与血液系统疾病的相关性研究报告
Yasser ElNahass,Nourhan Mekky,Nabil M Abdelfattah et al.
Yasser ElNahass et al.
HLA alleles are representative of ethnicities and may play important roles in predisposition to hematological disorders. We analyzed DNA samples for HLA-A, -B, -C, -DRB1, and -DQB1 loci, from 1550 patients and 4450 potential related donors ...
B-cells absence in patients diagnosed as inborn errors of immunity: a registry-based study [0.03%]
基于注册表的先天性免疫缺陷患者B细胞缺如特征分析
Razieh Khoshnevisan,Shakiba Hassanzadeh,Christoph Klein et al.
Razieh Khoshnevisan et al.
Hypogammaglobulinemia without B-cells is a subgroup of inborn errors of immunity (IEI) which is characterized by a significant decline in all serum immunoglobulin isotypes, coupled with a pronounced reduction or absence of B-cells. Approxim...
Determination of HLA class II risk alleles and prediction of self/non-self-epitopes contributing Hashimoto's thyroiditis in a group of Iranian patients [0.03%]
伊朗一组桥本甲状腺炎患者HLAⅡ类危险等位基因的确定及自身/非自身表位预测
Ata Shirizadeh,Shiva Borzouei,Zahra Razavi et al.
Ata Shirizadeh et al.
One of the probable hypotheses for the onset of autoimmunity is molecular mimicry. This study aimed to determine the HLA-II risk alleles for developing Hashimoto's thyroiditis (HT) in order to analyze the molecular homology between candidat...
Daniel Vázquez-Coto,Christine Kimball,Guillermo M Albaiceta et al.
Daniel Vázquez-Coto et al.
There is tremendous interindividual and interracial variability in the outcome of SARS-CoV-2 infection, suggesting the involvement of host genetic factors. Here, we investigated whether IgG allotypes GM (γ marker) 3 and GM 17, genetic mark...
A novel hemizygous CD40L mutation of X-linked hyper IgM syndromes and compound heterozygous DOCK8 mutations of hyper IgE syndromes in two Chinese families [0.03%]
两个中国家庭中X连锁高IgM综合征的新型CD40L半合子突变和高IgE综合征的DOCK8复合杂合子突变
Mingzhen Guo,Yuanxuan Ma,Kangxi Cai et al.
Mingzhen Guo et al.
X-linked hyper-immunoglobulin M (X-HIGM) syndrome and autosomal recessive hyper-immunoglobulin E syndrome (HIES) are rare inborn errors of immunity characterized by recurrent infections due to immune system impairment. In this study, we ide...
Case Reports
Immunogenetics. 2024 Jun;76(3):165-173. DOI:10.1007/s00251-024-01340-0 2024
HLA class I NK-epitopes and KIR diversities in patients with multiple myeloma [0.03%]
多发性骨髓瘤患者的I类人白细胞抗原NK表位和KIR多样性
Nicky A Beelen,Stefan J J Molenbroeck,Lisette Groeneveld et al.
Nicky A Beelen et al.
Multiple myeloma (MM) is a hematological malignancy caused by the clonal expansion of malignant plasma cells in the bone marrow. Myeloma cells are susceptible to killing by natural killer (NK) cells, but NK cells fail to control disease pro...
Lack of Syndecan-1 promotes the pathogenesis of experimental rheumatoid arthritis [0.03%]
Syndecan-1的缺乏促进实验性类风湿关节炎的发生和发展
Rosalyn Jurjus,Laura Dosh,Rima Farhat et al.
Rosalyn Jurjus et al.
Syndecan-1 (Sdc-1), a transmembrane heparan sulfate protein, is implicated in several pathophysiological processes including rheumatoid arthritis (RA). The exact role of Syndican-1 in this autoimmune disease is still undetermined. This stud...
Evolutionary divergence of TLR9 through ancestral sequence reconstruction [0.03%]
通过祖先序列重构分析TLR9的进化分歧
Manisha Ghosh,Surajit Basak,Shanta Dutta
Manisha Ghosh
The transmembrane pattern recognition receptor, Toll-like receptor (TLR), are best known for their roles in innate immunity via recognition of pathogen and initiation of signaling response. Mammalian TLRs recognize molecular patterns associ...