NOD alleles at Idd1 and Idd2 loci drive exocrine pancreatic inflammation [0.03%]
Idd1和Idd2位点的NOD等位基因驱动外分泌胰腺炎症
Laurence Caron,Daria Vdovenko,Félix Lombard-Vadnais et al.
Laurence Caron et al.
Non-obese diabetic (NOD) mice spontaneously develop autoimmune diabetes and have enabled the identification of several loci associated with diabetes susceptibility, termed insulin-dependent diabetes (Idd). The generation of congenic mice ha...
The effect of circulating cytokines on the risk of systemic lupus erythematosus: Mendelian randomization and observational study [0.03%]
循环细胞因子对系统性红斑狼疮风险的影响：孟德尔随机化和观察性研究
Dan Xue,Yu Qian,Xiao Tu et al.
Dan Xue et al.
Systemic lupus erythematosus (SLE) is a complex autoimmune disorder, the etiology of which involves the alterations in circulating cytokine levels. However, the cause-and-effect relationships and in-depth clinical relevance of them remain t...
Observational Study
Immunogenetics. 2024 Dec;76(5-6):315-322. DOI:10.1007/s00251-024-01351-x 2024
The characteristic of HLA-A, HLA-B, HLA-C, HLA-DRB1, HLA-DRB3/4/5, HLA-DQA1, HLA-DQB1, HLA-DPA1, and HLA-DPB1 alleles in Zhejiang Han population [0.03%]
汉族人群HLA-A、HLA-B、HLA-C、HLA-DRB1、HLA-DRB3/4/5、HLA-DQA1、HLA-DQB1、HLA-DPA1和HLA-DPB1等9个基因位点多态性分布特征研究
Sudan Tao,Xuan You,Nanying Chen et al.
Sudan Tao et al.
The Zhejiang Han population, a subgroup of the Southern Han ethnic group, resides in Zhejiang Province, situated on the southeast coast of China. In this study, we conducted HLA genotyping for 813 voluntary umbilical cord blood donors from ...
Decoding the genetic landscape of juvenile dermatomyositis: insights from phosphorylation-associated single nucleotide polymorphisms [0.03%]
儿童皮肌炎的遗传特征分析：来自与磷酸化相关的单核苷酸多态性的启示
Huan Zhang,Zhentao Zhang,Kedi Fan et al.
Huan Zhang et al.
Genome-wide association studies (GWASs) have identified genetic susceptibility loci associated with juvenile dermatomyositis (JDM). Single nucleotide polymorphisms related to phosphorylation (phosSNPs) are critical nonsynonymous mutations e...
Bioinformatic analysis predicts the regulatory function of noncoding SNPs associated with Long COVID-19 syndrome [0.03%]
生物信息学分析预测与长新冠综合征相关的非编码SNP的调控功能
Amit K Maiti
Amit K Maiti
Long or Post COVID-19 is a condition of collected symptoms persisted after recovery from COVID-19. Host genetic factors play a crucial role in developing Long COVID-19, and GWAS studies identified several SNPs/genes in various ethnic popula...
The sufficiency of genetic diagnosis in managing patients with inborn errors of immunity during prenatal care and childbearing [0.03%]
遗传诊断在孕期护理和生育过程中管理先天性免疫缺陷患者方面的充分性
Negin Salemi,Shima Bakhshesh,Amir Bahreini et al.
Negin Salemi et al.
Individuals with inborn errors of immunity face challenges in fertility, pregnancy, and genetic disorder transmission. Prenatal genetic counseling is crucial, especially in tribal societies with consanguineous unions. Ten families with conf...
A possible role of lncRNA MEG3 and lncRNA MAFG-AS1 on miRNA 147-b in the pathogenesis of Behcet's disease [0.03%]
长链非编码RNA MEG3和MAFG-AS1在白塞病发病机制中的可能作用及其与miRNA 147-b的关系研究
Shimaa Abobakr,Olfat Shaker,Mohamed Tharwat Hegazy et al.
Shimaa Abobakr et al.
Behcet's disease (BD) is a multisystem disease with altered Toll-like receptors (TLRs) on macrophages. Long noncoding RNA Maternally expressed gene 3 (lncRNA MEG3) and lncRNA Musculoaponeurotic fibrosarcoma oncogene family, protein G antise...
Associations between immune cell traits and autoimmune thyroid diseases: a bidirectional two-sample mendelian randomization study [0.03%]
免疫细胞特性与自身免疫性甲状腺疾病之间的关联：双向两样本孟德尔随机化研究
ZheXu Cao,JiangSheng Huang,Xia Long
ZheXu Cao
Autoimmune thyroid diseases (AITDs), mainly including Graves' disease (GD) and Hashimoto's thyroiditis (HT), are common autoimmune disorders characterized by abnormal immune responses targeting the thyroid gland. We conducted a bidirectiona...
Dog leukocyte antigen genotyping across class I and class II genes in beagle dogs as laboratory animals [0.03%]
利用试验用比格犬进行犬白细胞抗原经典I类和II类等位基因的分型研究
Hiroya Konno,Jiro Miyamae,Hiroko Kataoka et al.
Hiroya Konno et al.
Dog leukocyte antigen (DLA) polymorphisms have been found to be associated with inter-individual variations in the risk, susceptibility, and severity of immune-related phenomena. While DLA class II genes have been extensively studied, less ...
HLA alleles, haplotypes frequencies, and their association with hematological disorders: a report from 1550 families whose patients underwent allogeneic bone marrow transplantation in Egypt [0.03%]
埃及1550个接受异基因骨髓移植的家庭的人类白细胞抗原等位基因、单倍型频率及与血液系统疾病的相关性研究报告
Yasser ElNahass,Nourhan Mekky,Nabil M Abdelfattah et al.
Yasser ElNahass et al.
HLA alleles are representative of ethnicities and may play important roles in predisposition to hematological disorders. We analyzed DNA samples for HLA-A, -B, -C, -DRB1, and -DQB1 loci, from 1550 patients and 4450 potential related donors ...