VaxOptiML: leveraging machine learning for accurate prediction of MHC-I and II epitopes for optimized cancer immunotherapy [0.03%]
基于机器学习的MHC-I和II表位预测工具VaxOptiML用于优化癌症免疫治疗
Dhanushkumar T,Sunila B G,Sripad Rama Hebbar et al.
Dhanushkumar T et al.
Cancer immunotherapy hinges on accurate epitope prediction for advancing vaccine development. VaxOptiML (available at https://vaxoptiml.streamlit.app/ ) is an integrated pipeline designed to enhance epitope prediction and prioritization. Th...
Correction to: SNHG3 regulates NEIL3 via transcription factor E2F1 to mediate malignant proliferation of hepatocellular carcinoma [0.03%]
Correction to: SNHG3通过转录因子E2F1调节NEIL3介导肝细胞癌恶性增殖
Fabiao Zhang,Jie Lu,Jian Yang et al.
Fabiao Zhang et al.
Published Erratum
Immunogenetics. 2024 Dec 6;77(1):7. DOI:10.1007/s00251-024-01364-6 2024
Novel polymorphic and copy number diversity in the antibody IGH locus of South African individuals [0.03%]
南非个人的抗体IGH基因位点的新多态性和拷贝数多样性
Alaine A Marsden,Martin Corcoran,Gunilla Karlsson Hedestam et al.
Alaine A Marsden et al.
The heavy chain of an antibody is crucial for mediating antigen binding. IGHV genes, which partially encode the heavy chain of antibodies, exhibit vast genetic diversity largely through polymorphism and copy number variation (CNV). These ge...
Analysis of Complement Factor H gene polymorphisms and their association with clinical manifestations ofleptospirosis [0.03%]
补体因子H基因多态性分析及其与地方鼠型钩端螺旋体病临床表现关联的研究
Lazara Elena Santiesteban-Lores,Leonardo Moura Midon,ThirsaAlvares Franco et al.
Lazara Elena Santiesteban-Lores et al.
Leptospirosis is caused by pathogenic leptospires, posing a significant public health problem. Host susceptibility to Leptospira infection is a multifactorial trait, and the host's genetic background can influence both the establishment of ...
Spatial variation in toll-like receptor diversity in koala populations across their geographic distribution [0.03%]
无菌小鼠中肠道微生物群的组装及对免疫系统的影响
Jian Cui,Kimberley C Batley,Luke W Silver et al.
Jian Cui et al.
The koala (Phascolarctos cinereus) is an iconic Australian species that is listed as endangered in the northern parts of its range due to loss of habitat, disease, and road deaths. Diseases contribute significantly to the decline of koala p...
Exploring the therapeutic potential of interleukin-6 receptor blockade in autoimmune diseases using drug target mendelian randomization [0.03%]
利用药物靶点孟德尔随机化研究白细胞介素-6受体阻断在自身免疫性疾病中的治疗潜力
Jiaxin Li,Yalin Liu,Zheng Xiao et al.
Jiaxin Li et al.
The blockade of the interleukin 6 receptor (IL-6R) demonstrates significant potential in various autoimmune diseases (ADs); however, the underlying therapeutic efficacy associated with this approach remains elusive. We conducted a comprehen...
A novel mutation in FNIP1 associated with a syndromic immunodeficiency and cardiomyopathy [0.03%]
FNIP1的新突变与综合征性免疫缺陷和心肌病相关
Ilia Spivak,Atar Lev,Amos J Simon et al.
Ilia Spivak et al.
Genetic variants in Folliculin interacting protein 1 (FNIP1) were recently discovered as monogenic causes for immunodeficiency and cardiomyopathy, with only a few patients diagnosed thus far. In this study, we describe a patient harboring a...
Case Reports
Immunogenetics. 2024 Nov 14;77(1):2. DOI:10.1007/s00251-024-01359-3 2024
Epistatic effects of IGHG and FCGRIIB genes on the development of Alzheimer's disease in African Americans [0.03%]
IGHG和FCGR2B基因在非裔美国人中对阿尔茨海默病发病的上位效应分析
Janardan P Pandey,Paul J Nietert,Aryan M Namboodiri et al.
Janardan P Pandey et al.
Genome-wide association studies (GWAS) of Alzheimer's disease (AD) have identified a large number of susceptibility genes, but most of AD heritability remains unexplained, implying the existence of additional genes. Furthermore, the majorit...
Evolutionary diversity of CXCL16-CXCR6: Convergent substitutions and recurrent gene loss in sauropsids [0.03%]
趋同替换和爬行亚纲中白细胞趋化因子受体6基因的反复丢失驱动的CXCL16-CXCR6进化多样性
Buddhabhushan Girish Salve,Sandhya Sharma,Nagarjun Vijay
Buddhabhushan Girish Salve
The CXCL16-CXCR6 axis is crucial for regulating the persistence of CD8 tissue-resident memory T cells (TRM). CXCR6 deficiency lowers TRM cell numbers in the lungs and depletes ILC3s in the lamina propria, impairing mucosal defence. This axi...
Using bioinformatics to investigate functional diversity: a case study of MHC diversity in koalas [0.03%]
利用生物信息学研究功能多样性的一个案例：考拉MHC多样性的研究
Luke W Silver,Elspeth A McLennan,Julian Beaman et al.
Luke W Silver et al.
Conservation genomics can greatly improve conservation outcomes of threatened populations, including those impacted by disease. Understanding diversity within immune gene families, including the major histocompatibility complex (MHC) and to...