Phylogenetic and structural insights into the origin of C-type lectin Mincle in vertebrates [0.03%]
脊椎动物C型凝集素Mincle起源的系统发育和结构研究
Taiki Ito,Carla Guenther,Eri Ishikawa et al.
Taiki Ito et al.
Our bodies are continuously exposed to injurious insults by infection and tissue damage, which are primarily sensed by innate immune receptors to maintain homeostasis. Among such receptors is macrophage-inducible C-type lectin (Mincle, gene...
Hans-Georg Rammensee,Olaf Rötzschke
Hans-Georg Rammensee
Suppressed activation of the IRF7 and TLR9 by JAK2V617F gold nanoparticles [0.03%]
JAK2V617F金纳米颗粒对IRF7和TLR9的激活抑制作用
Berkay Tokcan,Esra Nur Demirtaş,Selçuk Sözer
Berkay Tokcan
Philadelphia chromosome-negative myeloproliferative neoplasms (Ph-MPNs) are characterized by the overproduction of myeloid cells and a lack of response to cytokine signaling, along with genomic instability and the accumulation of nucleic ac...
Primary regulatory T cell activator FOXP3 is present across Amphibia [0.03%]
主要的调节性T细胞活化因子FOXP3在两栖动物中存在
Rebecca A Clemons,Chase H Smith,Kelly R Zamudio
Rebecca A Clemons
The overall structure of the immune system is highly conserved across jawed vertebrates, but characterization and description of the immune system is heavily biased toward mammals. One arm of the vertebrate immune system, the adaptive immun...
Full-length mRNA sequencing resolves novel variation in 5' UTR length for genes expressed during human CD4 T-cell activation [0.03%]
全长mRNA测序解析人类CD4 T细胞活化过程中基因5'UTR长度的新变异
Cassandra R Woolley,Julia H Chariker,Eric C Rouchka et al.
Cassandra R Woolley et al.
Isoform sequencing (Iso-Seq) uses long-read technology to produce highly accurate full-length reads of mRNA transcripts. Visualization of individual mRNA molecules can reveal new details of transcript variation within understudied portions ...
HCV immunodominant peptide mapping reveals unique HLA-A*02-restricted signatures: insights for CD8+ T-cell-based vaccines and immunotherapies [0.03%]
乙型肝炎病毒免疫优势肽的图谱鉴定发现独特的HLA-A*02限制特征：基于CD8+T细胞疫苗和免疫治疗的启示
Laura Cardoso Corrêa-Dias,Ágata Lopes-Ribeiro,Geovane Marques-Ferreira et al.
Laura Cardoso Corrêa-Dias et al.
Several barriers for the development of an HCV vaccine still exist, including the genetic diversity of the virus, and the shortage of assessable models for in vitro and in vivo assays. Therefore, in this study, HCV epitope mapping was perfo...
In silico functional analysis of the human, chimpanzee, and gorilla MHC-A repertoires [0.03%]
人类、黑猩猩和大猩猩MHC-A组库的计算机功能分析
Griffin Kutler Dodd,Can Keşmir
Griffin Kutler Dodd
T cells recognize peptides displayed on the surface of cells on MHC molecules. Genetic variation in MHC genes alters their peptide-binding repertoire and thus influences the potential immune response generated against pathogens. Both gorill...
AMPed up immunity: 418 whole genomes reveal intraspecific diversity of koala antimicrobial peptides [0.03%]
增强的免疫力：418个全长基因组揭示了考拉抗菌肽的种内多样性
Cleopatra Petrohilos,Emma Peel,Luke W Silver et al.
Cleopatra Petrohilos et al.
Characterising functional diversity is a vital element to understanding a species' immune function, yet many immunogenetic studies in non-model organisms tend to focus on only one or two gene families such as the major histocompatibility co...
Uncovering selection pressures on the IRF gene family in bats' immune system [0.03%]
揭示蝙蝠免疫系统中IRF基因家族的选择压力
Edgar G Gutierrez,Jorge Ortega
Edgar G Gutierrez
Unlike other mammals, bats serve as natural reservoirs for several highly pathogenic viruses without exhibiting symptoms of infection. Recent research has explored the complex mechanisms underlying the balance between bats' antiviral defens...
Lara Diab,Sahar Al Kattar,Naim Oueini et al.
Lara Diab et al.
Syndecan-1 (SDC-1) is a transmembrane protein localized on the basolateral surface of epithelial cells, encompassing a core protein with heparin sulfate and chondroitin sulfate glycosaminoglycan side chains. SDC-1 is involved in a panoply o...