Necessity of individual VDJ-databases for annotating antibody heavy chain characteristics in non-human primates [0.03%]
非人灵长类抗体重链特征注释的VDJ数据库的必要性
Aafke Aartse,Jacco G J Bakx,Daniella Mortier et al.
Aafke Aartse et al.
Non-human primates are important for preclinical vaccine evaluation. In depth characterization of the antibody response requires representative immunoglobulin (IG) germline gene databases for correct gene and allele assignments and assessme...
Evolution of SAMD9 and SAMD9L genes in primates: a complex history of gene loss, gene duplication and pseudogenization [0.03%]
灵长类动物SAMD9和SAMD9L基因的进化：基因丢失、基因复制及假基因化的复杂历史
António Duarte,Ana Pinheiro,Pedro José Esteves
António Duarte
Compact genomic architecture of the axolotl MHC region: setting the record straight [0.03%]
.axl基因组MHC区的精简结构：正本清源
Magdalena Migalska,Krzysztof Fluder,Katarzyna Dudek et al.
Magdalena Migalska et al.
The Major Histocompatibility Complex (MHC) is a gene-dense genomic region essential to adaptive immunity, exhibiting both conserved features and lineage-specific rearrangements across jawed vertebrates. Amphibians, as basal tetrapods, offer...
Evaluation of lymphoid defects in specific inborn errors of immunity using a single-tube multicolor flow cytometry assay [0.03%]
应用多重流式细胞检测法评估先天性免疫缺陷病的淋巴细胞缺陷
Reja Tanveer,Sanchi Chawla,Saniya Sharma et al.
Reja Tanveer et al.
The present study aimed to evaluate lymphoid defects in patients with specific IEIs (n = 28) using a 12-antibody 9-color single-tube flow cytometry assay. The lymphoid defects (lymphocyte counts below the reference range) were significantly...
Genetic insights into the major histocompatibility complex class I BF2 gene of Korean native chickens in relation to the LEI0258 microsatellite marker and the 90-SNP panel [0.03%]
与LEI0258微卫星标记和90-SNP基因分型面板有关的韩国地方鸡MHC-I类BF2基因遗传研究
Trisha Nicole Agulto,Minjun Kim,Prabuddha Manjula et al.
Trisha Nicole Agulto et al.
The chicken major histocompatibility complex (MHC) represents a "minimal essential MHC" consisting of classical class I (BF) and class II (BL) molecules that present peptides to CD8+ cytotoxic and CD4+ helper T cells, respectively. Class I ...
Immunoglobulin genetics of a model squamate reptile, Tiliqua rugosa [0.03%]
沙蜥蜴(Tiliqua rugosa)的免疫球蛋白遗传学特性研究
Jordan M Sampson,Kieran J Mikolajova,Michael G Gardner et al.
Jordan M Sampson et al.
Squamate reptiles are a diverse group of terrestrial vertebrates that includes over 10,000 species. Despite their broad distribution, they are relatively understudied immunologically. Fortunately, recent advances in comparative genomics hav...
Association between single-nucleotide polymorphism rs868875 of CLEC4M gene and clinical severity of COVID-19 in a Brazilian population [0.03%]
巴西人群中CLEC4M基因单核苷酸多态性rs868875与新冠肺炎临床严重程度相关性的研究
Steffany Larissa Galdino Galisa,Marcus Villander Barros de Oliveira Sá,Natália Machado Tavares et al.
Steffany Larissa Galdino Galisa et al.
COVID-19, caused by the SARS-CoV-2 virus, has had a global impact, leading to high incidence and mortality rates worldwide. Host genetics significantly influence individual susceptibility to severe COVID-19. The C-type lectin domain family ...
Genetic diversity of BoLA-DRB3 in Latin American Creole cattle: an update of the state of the art [0.03%]
拉美牛科伊尔牧群BoLA-DRB3基因多态性研究进展报告
Olivia Marcuzzi,Guillermo Giovambattista,Ariel Loza Vega et al.
Olivia Marcuzzi et al.
Genetic diversity of the bovine leukocyte antigen BoLA-DRB3 gene has been reported in cattle breeds due to its central role in immune response. However, the gene has been characterized in only a few Latin American native cattle breeds. In t...
Immunoglobulin GM (γ marker) and FcγR genotypes interact to contribute to the magnitude of ADCC against SARS CoV-2 S-transfected cells [0.03%]
免疫球蛋白GM（γ标记）和FcγR基因型互作，共同决定了针对SARS-CoV-2 S转染细胞的ADCC水平
Janardan P Pandey,Aryan M Namboodiri,Paul J Nietert
Janardan P Pandey
Immunoglobulin GM (γ marker) and KM (κ marker) allotypes have been shown to be associated with antibody responses to several viruses, but their role in immunity to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-the causative...
Dysregulation of lncRNAs in NK cells from breast cancer patients: implications for NK cell functions [0.03%]
乳腺癌患者NK细胞中lncRNA失调：对NK细胞功能的影响
Mona Rady,Eman Mohamed,Ola Khorshid et al.
Mona Rady et al.
Natural killer (NK) cells, a key component of the innate immune system, play a crucial role in detecting and eliminating cancer cells, contributing to cancer immune surveillance. Increasing evidence suggests that NK cell functions are regul...