Edward J Hollox,Sandra Louzada
Edward J Hollox
Glycophorins are transmembrane proteins of red blood cells (RBCs), heavily glycosylated on their external-facing surface. In humans, there are four glycophorin proteins, glycophorins A, B, C and D. Glycophorins A and B are encoded by two si...
Whole exome sequencing identified a novel splice donor site variant in interleukin 2 receptor alpha chain [0.03%]
全外显子组测序鉴定出新型白细胞介素-2受体α链剪接供体位点变异
Nadia Waheed,Maryam Naseer,Nighat Haider et al.
Nadia Waheed et al.
Interleukin 2 receptor alpha chain (IL-2Rα or CD25) deficiency (OMIM #606367) is an immune dysregulation disorder segregating in autosomal recessive form. The disease is caused by biallelic variants in the IL-2Rα gene encoding IL-2Rα als...
Case Reports
Immunogenetics. 2023 Apr;75(2):71-79. DOI:10.1007/s00251-022-01278-1 2023
SNHG3 regulates NEIL3 via transcription factor E2F1 to mediate malignant proliferation of hepatocellular carcinoma [0.03%]
SNHG3通过转录因子E2F1调节NEIL3介导肝细胞癌恶性增殖
Fabiao Zhang,Jie Lu,Jian Yang et al.
Fabiao Zhang et al.
The involvement of small nucleolar RNA host gene 3 (SNHG3) in cancer regulation has been reported. This study attempted to deeply investigate the molecular regulatory mechanism of SNHG3 on malignant progression of hepatocellular carcinoma (...
Mutated Pkhd1 alone is sufficient to cause autoimmune biliary disease on the nonobese diabetic (NOD) genetic background [0.03%]
Pkhd1突变本身在非肥胖糖尿病基因型背景上即可引起自身免疫性胆管病
David E Adams,Luke S Heuer,Manuel Rojas et al.
David E Adams et al.
We previously reported that nonobese diabetic (NOD) congenic mice (NOD.c3c4 mice) developed an autoimmune biliary disease (ABD) with similarities to human primary biliary cholangitis (PBC), including anti-mitochondrial antibodies and organ-...
IL4I1 enhances PD-L1 expression through JAK/STAT signaling pathway in lung adenocarcinoma [0.03%]
IL4I1通过JAK/STAT信号通路增强肺腺癌中PD-L1的表达
Jiefei Zhu,Yan Li,Xu Lv
Jiefei Zhu
Lung adenocarcinoma (LUAD) is the major type of lung cancer and is one of the deadliest cancers worldwide. IL4I1, as a gene associated with unsatisfactory prognosis, is involved in tumor immune escape, but its immune regulatory mechanism in...
Functional consequences of allotypic polymorphisms in human immunoglobulin G subclasses [0.03%]
人类免疫球蛋白G亚类中的表型多态的功能后果
Andrew R Crowley,Simone I Richardson,Marina Tuyishime et al.
Andrew R Crowley et al.
Heritable polymorphisms within the human IgG locus, collectively termed allotypes, have often been linked by statistical associations, but rarely mechanistically, to a wide range of disease states. One potential explanation for these associ...
Oncogenic signaling pathway mediated by Notch pathway-related genes induces immunosuppression and immunotherapy resistance in hepatocellular carcinoma [0.03%]
由Notch通路相关基因介导的致癌信号通路在肝细胞癌中诱导免疫抑制和免疫治疗抵抗
Peng Ma,Chuanxin Zou,Shitao Xia
Peng Ma
The Notch pathway is a highly conserved signaling pathway involved in the regulation of cell proliferation and differentiation. However, the relationships between Notch pathway-related genes (NPRGs), immunosuppression, and immunotherapy res...
A highly diverse set of novel immunoglobulin-like transcript (NILT) genes in zebrafish indicates a wide range of functions with complex relationships to mammalian receptors [0.03%]
一套高度多样化的新型免疫球蛋白样转录本（NILT）基因表明斑马鱼具有广泛的功能并且与哺乳动物受体有着复杂的关系
Dustin J Wcisel,Alex Dornburg,Sean C McConnell et al.
Dustin J Wcisel et al.
Multiple novel immunoglobulin-like transcripts (NILTs) have been identified from salmon, trout, and carp. NILTs typically encode activating or inhibitory transmembrane receptors with extracellular immunoglobulin (Ig) domains. Although predi...
Identification of potential predictive biomarkers and biological pathways and the correction with immune infiltration in the activation of Crohn's disease [0.03%]
识别潜在的预测生物标志物和生物学途径并用免疫浸润校正在克罗恩病中的作用
Wei-Ming Zhong,Xiao-Hang Qian,Zhe-Wu Jin
Wei-Ming Zhong
Crohn's disease (CD), a subtype of inflammatory bowel disease (IBD), has increasing prevalence in the world. Due to the lack of cure strategy, most patients with CD develop progressive disease companying with a series of serious complicatio...
Correction to: Multiple Alr genes exhibit allorecognition-associated variation in the colonial cnidarian Hydractinia [0.03%]
correction to：“藻菌素基因在殖民型刺胞动物hydractiniavirgularis的亲和识别中的变异现象研究
Henry Rodriguez-Valbuena,Andrea Gonzalez-Muñoz,Luis F Cadavid
Henry Rodriguez-Valbuena
Published Erratum
Immunogenetics. 2022 Dec;74(6):583. DOI:10.1007/s00251-022-01271-8 2022