Methodological framework for chromogenic mRNA detection using in situ hybridization chain reaction [0.03%]
原位杂交链反应法检测mRNA的实验框架方法学研究
Mitsuru Yashiro,Yousuke Tsuneoka,Yusuke Atsumi et al.
Mitsuru Yashiro et al.
In situ hybridization chain reaction (HCR) is a highly sensitive method for visualizing single-molecule messenger RNA (mRNA) using self-assembling hairpin DNA pairs. However, conventional in situ HCR is primarily optimized for fluorescence ...
Rabia Gönül,Agnieszka Chytła,Ana Miladinović et al.
Rabia Gönül et al.
Phosphoinositides are low-abundance regulatory lipids that control a broad range of cellular processes, from membrane trafficking and cytoskeletal remodeling to transcriptional regulation and RNA processing. These lipids are distributed acr...
Effects of obesity on DNA methylation and DNA methyltransferases in the reproductive system [0.03%]
肥胖对生殖系统DNA甲基化和DNA甲基转移酶的影响
Gözde Şükür,Özgür Çınar,Fatma Uysal Çınar
Gözde Şükür
Obesity is increasingly recognized as a condition with profound systemic and epigenetic consequences. However, the molecular mechanisms linking obesity to reproductive dysfunction remain incompletely understood. Accumulating evidence sugges...
SASP-driven vascular aging: unraveling the transcriptional nexus in endothelial senescence and cardiovascular disease [0.03%]
衰老相关分泌表型驱动的血管衰老：内皮细胞衰老和心血管疾病中的转录调控网络解析
Shuqing Mao,Jian Cui
Shuqing Mao
Endothelial cell senescence represents a critical mechanistic driver in the initiation and progression of cardiovascular diseases. Senescent endothelial cells exhibit characteristic features, including cell cycle arrest-mediated primarily t...
Localization of dendritic cells and T cells within the tumor microenvironment in different types of skin cancer [0.03%]
不同类型的皮肤癌中树突状细胞和T细胞在肿瘤微环境中的定位
Marina Wanner,Anna Brunner,Daniela Ortner et al.
Marina Wanner et al.
Immunophenotyping of tumor-infiltrating immune cells is increasingly important for understanding the tumor microenvironment (TME), particularly in the diagnosis and treatment of skin cancer. CD1a+ dendritic cells (DC) initiate T cell activa...
Oncogenic overexpression of kallikrein-related peptidase 7 is associated with the progression of thyroid cancer [0.03%]
激肽原酶相关丝氨酸蛋白酶7的致癌过表达与甲状腺癌进展有关
Shun-Yu Chi,Chi-Yu Kuo,Shih-Yuan Huang et al.
Shun-Yu Chi et al.
Mounting evidence suggests that the kallikrein-related peptidase family is dysregulated in thyroid cancer. However, previous analyses of kallikrein-related peptidase 7 (KLK7) expression patterns have yielded inconsistent results. In this st...
Functional suppression accompanies internal mitochondrial reorganization during cellular reprogramming [0.03%]
细胞重编程过程中伴随功能抑制的内部线粒体重组
N Diak,L Sieroń,K Janelt et al.
N Diak et al.
During the conversion of fibroblasts into induced pluripotent stem cells (iPSCs), cellular metabolism shifts from oxidative phosphorylation toward glycolysis; however, how functional and structural mitochondrial adaptations are coordinated ...
Fiber type-specific expression of LACTB leverages a function in oxidative metabolism [0.03%]
LACTB的纤维类型特异性表达在氧化代谢中发挥作用
Kirsi-Marja Alanen,Rabah Soliymani,Jaakko Sarparanta et al.
Kirsi-Marja Alanen et al.
Skeletal muscle is composed of type I and type II fibers, each characterized by specific metabolic machinery. LACTB is a conserved mitochondrial protein implicated in lipid utilization and tumorigenesis, but its precise function in the cell...
ER stress affects proliferation and induces polyploidization of cultured human HaCaT and A431 cells [0.03%]
内质网应激影响培养的人HaCaT和A431细胞的增殖并诱导多倍体化
Ilia I Zakharov,Polina A Veselova,Margarita A Savitskaya et al.
Ilia I Zakharov et al.
Endoplasmic reticulum (ER) stress is the accumulation of misfolded or defective proteins in the ER. ER stress is capable of inducing both anti-apoptotic and pro-apoptotic cellular response, and at the same time plays an important role in me...
Periostin in joint physiology and pathology: multiple roles from mechanisms to clinical perspectives [0.03%]
骨膜素在关节生理和病理中的作用：从机制到临床视角的多重角色
Qiaoli Dai,Zuping Wu,Ying Wang et al.
Qiaoli Dai et al.
Joint-related diseases, including osteoarthritis (OA), rheumatoid arthritis (RA), intervertebral disc degeneration (IDD), anterior cruciate ligament (ACL) injury, and shoulder instability, severely compromise human health. Periostin (POSTN)...