High-sucrose diet induces MMP-9 activation and collagen deposition via oxidative stress in Swiss mice liver [0.03%]
高糖饮食通过氧化应激诱导瑞士小鼠肝脏基质金属蛋白酶活化及胶原沉积
Mariana Alves Passos,Juliana Leticia Silva,Túlio César Rodrigues Leite et al.
Mariana Alves Passos et al.
Excessive sucrose consumption is associated with various metabolic disorders, including obesity, diabetes, and liver dysfunction. Although oxidative stress is a well-established mechanism contributing to these conditions, its effects on mat...
Longitudinal progression of tissue remodeling in experimental pulmonary hypertension is accompanied by a continuously increasing re-expression of extra domain A-containing fibronectin [0.03%]
实验性肺动脉高压组织重塑的纵向发展伴基底膜型纤连蛋白可变剪接形式（FNEDA）再表达的不断增加
Laura Tempel,Andrea Schrepper,Alexander Berndt et al.
Laura Tempel et al.
Pulmonary hypertension (PH) is a progressive disease characterized by pulmonary vascular remodeling and increasing right ventricular (RV) afterload. Extracellular matrix (ECM) remodeling is central to PH, but its temporal dynamics across lu...
Plectin-mediated mitochondrial fusion is necessary for hepatocellular carcinoma cell migration promoted by higher matrix stiffness [0.03%]
黏着斑蛋白介导的线粒体融合对更高基质刚度促进肝癌细胞迁移的必要性
Zhihui Wang,Wenbin Wang,Xu Zhang et al.
Zhihui Wang et al.
Increased matrix stiffness is a key physical signal affecting the migration of hepatocellular carcinoma (HCC) cells, and mitochondrial dynamics and function also play important roles in cell migration. Plectin may influence mitochondrial dy...
YAP/TEAD complex restricts H3K27ac deposition to suppress testosterone synthesis in adult Leydig cells [0.03%]
YAP/TEAD复合体通过抑制成人Leydig细胞中的睾酮合成来限制H3K27ac沉积
Zeyu Lin,Shanshan Luo,Mei Zheng et al.
Zeyu Lin et al.
The Hippo signaling pathway regulates the development of multiple organs, yet its role in the maturation of adult Leydig cells and testosterone synthesis is unclear. In this study, by integrating bulk RNA sequencing and immunohistochemistry...
Predominant NR1-positive puncta with limited PSD95 colocalization and close GluA2-EAAT2 apposition in the preBötzinger complex [0.03%]
前Bötzinger复合体中以NR1阳性斑点为主，PSD95部分共定位以及GluA2-EAAT2相邻接近
Carol Alejandra Olmos-Pastoresa,Enrique Vázquez-Mendoza,Olivia Vázquez-Martínez et al.
Carol Alejandra Olmos-Pastoresa et al.
The preBötzinger complex (preBötC) is a medullary network that generates the inspiratory phase of respiratory rhythm in mammals and depends critically on glutamatergic transmission. To characterize the anatomical organization of excitator...
Endoplasmic reticulum stress is associated with cardiac effects of bisphenol S independently of a high-fat diet [0.03%]
独立于高脂饮食，双酚S的心脏效应与内质网应激相关
Beatriz Alexandre-Santos,Guilherme Dos Santos Reis,Luiza Mazzali Ferraz et al.
Beatriz Alexandre-Santos et al.
Obesity and endocrine disruptors (EDs) promote endoplasmic reticulum (ER) stress, a mechanism associated with cardiovascular diseases. Among EDs, BPS is widely used in consumer products. Whether BPS promotes cardiac ER stress, either alone ...
An improved method for Gill's hematoxylin and eosin staining based on the optimal acetic acid ratio [0.03%]
基于最佳冰醋酸比例的改良吉姆萨染色方法
Zhijie Ma,Caixia Sheng,Danju Wu et al.
Zhijie Ma et al.
The staining performance of hemalum solutions is critically dependent on pH, yet the acetic acid content varies among different hemalum formulations. This study aimed to clarify the relationship between the acetic acid ratio (pH) of Gill's ...
Development of a 3D collagen type I hydrogel scaffold for modeling hyperglycemia-induced spinal neuronal damage and therapeutic evaluation [0.03%]
开发一种三维I型胶原水凝胶支架，用于模拟高血糖诱导的脊髓神经元损伤及药物筛选模型
Mohammad Ranjbar,Kianoosh Ghiasvand,Banafsheh Rastegari et al.
Mohammad Ranjbar et al.
This study aimed to develop a three-dimensional (3D) collagen type I hydrogel scaffold for modeling spinal neuron culture under high-glucose conditions, thereby simulating environments such as diabetic neuropathy and maternal diabetes. Hydr...
Amifostine alleviates ionizing radiation-induced small intestinal motility dysfunction in mice by remodeling the structure of the enteric nervous system [0.03%]
氨磷汀通过重塑肠神经系统结构改善小鼠放射性肠病诱导的小肠运动功能障碍
Sha-Sha Tao,Yan Li,Fei Li et al.
Sha-Sha Tao et al.
Radiation-induced intestinal injury is characterized by structural and functional impairment of intestinal tissues following exposure to ionizing radiation, and homeostasis of the enteric nervous system is essential for preserving normal ga...
Bioactive adipose-derived ECM hydrogel loaded with cytokine-releasing microspheres promotes spinal cord repair by suppressing inflammation, apoptosis, oxidative stress, and ferroptosis [0.03%]
负载细胞因子缓释微球的生物活性脂肪源性ECM水凝胶通过抑制炎症、凋亡、氧化应激和铁死亡促进脊髓修复
Amani Alghamdi,Suad A Alghamdi,Amal A Albati et al.
Amani Alghamdi et al.
Spinal cord injury (SCI) is a devastating neurological condition characterized by severe neuronal loss, inflammation, oxidative stress, and various forms of regulated cell death that collectively impair functional recovery. The present stud...