Unexpected beneficial effects of drugs: an analysis of cases in the Dutch spontaneous reporting system [0.03%]
药物的意外有益作用：荷兰自发呈报系统的病例分析
Florence van Hunsel,Corine Ekhart
Florence van Hunsel
Introduction: Drug use is inherently related to both beneficial effects on health as well as the occurrence of risks. The beneficial effects may be related to efficacy, the treatment range of a product, or even to user-fr...
Causality assessment between reported fatal cerebral haemorrhage and suspected drugs: developing a new algorithm based on the analysis of the Japanese Adverse Event Report (JADER) database and literature review [0.03%]
基于日本不良事件报告(JADER)数据库和文献回顾分析的药物与报道的致死性脑出血关联评价算法研究
Miki Ohta
Miki Ohta
Purpose: Cerebral haemorrhage is a life-threatening event with various causes including adverse drug reactions (ADRs). Several methods have been proposed for the causality assessment of ADRs, but none specific for cerebra...
Are adverse drug reactions to anti-diabetic drugs more common in patients whose treatment do not adhere to diabetes management clinical guidelines? Comments on a study report [0.03%]
受试者未按照糖尿病管理指南用药，抗糖尿病药物的不良反应发生率更高吗？对一项研究报告的看法
Zahra Rezaie,Maryam Taghizadeh-Ghehi,Aarefeh Jafarzadeh Kohneloo
Zahra Rezaie
Population pharmacokinetic model of subcutaneous fentanyl in older acute care patients [0.03%]
老年急性期护理患者皮下注射芬太尼的药动学模型
Aymen A Al-Qurain,Richard Upton,Desmond B Williams et al.
Aymen A Al-Qurain et al.
Purpose: Subcutaneous fentanyl injection is commonly prescribed to manage acute pain in older patients; however, there is a gap in the literature describing the pharmacokinetic parameters for this route of administration ...
Pharmacokinetic interaction between atorvastatin and fixed-dose combination of sofosbuvir/ledipasvir in healthy male Egyptian volunteers [0.03%]
阿托伐他汀与索磷布韦/利巴韦林固定剂量复方制剂在健康埃及男性受试者中的药物相互作用研究
H A Elmekawy,F Belal,A E Abdelaziz et al.
H A Elmekawy et al.
Purpose: Comorbid conditions of heart and liver disorders added to HCV-induced hepatic steatosis make co-administration of statins, and direct-acting antivirals is common in clinical practice. This study aimed to evaluate...
Randomized Controlled Trial
European journal of clinical pharmacology. 2021 Sep;77(9):1369-1379. DOI:10.1007/s00228-021-03130-z 2021
Safety and efficacy of new oral anticoagulants compared to those of warfarin in AF patients with cancer: a meta-analysis of randomized clinical trials and observational studies [0.03%]
与华法林相比新型口服抗凝药在房颤合并肿瘤患者中的安全性和有效性：随机临床试验和观察性研究的meta分析
Yueming Chen,Min Mao,Jing Chang et al.
Yueming Chen et al.
Background: Data on the efficacy and safety of nonvitamin K antagonist oral anticoagulants (NOACs) in atrial fibrillation (AF) patients with cancer are limited. Therefore, we conducted a meta-analysis to compare the effic...
Randomized, placebo-controlled trial of orally administered vitamin K1 for warfarin-associated coagulopathy in Chinese patients with mechanical heart valves [0.03%]
口服维生素K1治疗机械心脏瓣膜的中国患者华法林相关性凝血功能障碍的随机、安慰剂对照临床试验
Heng Zhang,Mei Li,Xue-Lian Ao et al.
Heng Zhang et al.
Purpose: Warfarin-associated coagulopathy commonly occurs in patients undergoing treatment with this anticoagulant. This trial aimed to determine the efficacy of using low-dose orally administered vitamin K1 to lower inte...
Randomized Controlled Trial
European journal of clinical pharmacology. 2021 Sep;77(9):1333-1339. DOI:10.1007/s00228-021-03127-8 2021
The impacts of race and regimens on the efficacy and safety of paclitaxel and platinum combination treatment for patients with advanced non-small cell lung cancer [0.03%]
种族和方案对晚期非小细胞肺癌患者紫杉醇联合铂类化疗疗效及安全性的影响
Chenyang Zhao,Fengli Wang,Jihan Huang et al.
Chenyang Zhao et al.
Purpose: Paclitaxel-platinum chemotherapy is the first-line treatment for advanced non-small cell lung cancer (NSCLC) patients. This study quantitatively evaluated the factors influencing the efficacy and safety of the pa...
Non-steroidal anti-inflammatory drug-associated acute kidney injury: does short-term NSAID use pose a risk in hospitalized patients? [0.03%]
非甾体抗炎药相关的急性肾损伤：短期使用非甾体抗炎药物会对住院患者造成风险吗？
Nakyung Jeon,Haesuk Park,Richard Segal et al.
Nakyung Jeon et al.
Purpose: While renal risk associated with short-term use of non-steroidal anti-inflammatory drugs (NSAID) has been anecdotally documented, no conclusive evidence is available on the renal safety, especially among hospital...
Essentials in saline pharmacology for nasal or respiratory hygiene in times of COVID-19 [0.03%]
新冠病毒疫情期间鼻或呼吸护理的盐水药理学要点
Suzy Huijghebaert,Levi Hoste,Guido Vanham
Suzy Huijghebaert
Purpose: Nasal irrigation or nebulizing aerosol of isotonic or hypertonic saline is a traditional method for respiratory or nasal care. A recent small study in outpatients with COVID-19 without acute respiratory distress ...