Efficacy and safety of doravirine/islatravir for the treatment of HIV-1: a systematic review and meta-analysis of randomized controlled trials with GRADE assessment [0.03%]
多拉韦林/伊斯拉特韦治疗HIV-1的疗效和安全性：随机对照试验系统评价和GRADE评估meta分析
Mohammed R Abdeldayem,Ahmed Elsherbeeny,Ahmad Beddor
Mohammed R Abdeldayem
Purpose: Two-drug antiretroviral regimens are being investigated as alternatives to standard three-drug therapy for HIV-1. Doravirine/islatravir is a once-daily oral combination with promising efficacy and safety, but its...
Critical analysis of digitalis glycosides: declining use but increasing poison-center exposure cases for digitoxin [0.03%]
地高辛及其他数字苷的批判分析：使用量下降，但中毒病例增加
Paul Antek Matthias Ecker,Andreas Schaper,Hans Jörg Bräunig et al.
Paul Antek Matthias Ecker et al.
Purpose & background: Belonging to one of the oldest drug classes in cardiovascular-medicine, the scientific interest in Na+/K+-ATPase inhibitors (NKA-inhibitors, digitalis glycosides) has increased once again after the p...
Interpreting neutral findings in CA-AKI prevention trials: additional methodological considerations [0.03%]
解读CA-AKI预防试验中的阴性结果：其他方法学考量
Zubaida Bibi,Kausar Ali
Zubaida Bibi
The effect of Pemafibrate on glucose metabolism and FGF21: a systematic review and meta-analysisa of randomized controlled trials [0.03%]
Pemafibrate对糖代谢和FGF21的影响：随机对照试验的系统评价和meta分析
Haiyan Li,Hengyuan Yu,Mohammad Hassan Sohouli
Haiyan Li
Background: Pemafibrate, a selective peroxisome proliferator-activated receptor alpha (PPARα) modulator, has shown potential in improving metabolic parameters. However, its effects on key metabolic biomarkers and fibrobl...
A decade of progress in small-cell lung cancer (2015-2025): a narrative review [0.03%]
小细胞肺癌的十年进展（2015-2025）：叙述性综述
Fausto Petrelli,Lorenzo Dottorini,Antonio Ghidini et al.
Fausto Petrelli et al.
Introduction: Small-cell lung cancer (SCLC) accounts for 13-15% of lung-cancer diagnoses but nearly one quarter of lung-cancer-related deaths. Until 2015, the combination of platinum-etoposide chemotherapy, thoracic radio...
Correspondence: Strengthening evidence traceability in written drug promotion to support rational prescribing [0.03%]
作者来信：通过书面药物推广加强证据可追溯性以支持合理处方用药
M Vijayasimha,M Srikanth
M Vijayasimha
Written promotional materials from pharmaceutical companies continue to influence prescribing behaviour despite evolving regulatory oversight. Recent evidence from the European Journal of Clinical Pharmacology highlights persistent structur...
Efficacy of different pharmacological therapies for diffuse cutaneous systemic sclerosis: a systematic review and network meta-analysis [0.03%]
不同药物疗法治疗系统性硬化病的疗效：系统评价和网状Meta分析
Xian Chen,Feifei Yuan,Kunkun Wang et al.
Xian Chen et al.
Objective: This study aims to compare the effectiveness of different pharmacological therapies for diffuse cutaneous systemic sclerosis (dcSSc) through a network meta-analysis (NMA). ...
Candidate-gene-based study of CYP3A-related single-nucleotide polymorphisms using 4β-hydroxycholesterol/cholesterol ratio as biomarker in a Japanese cohort [0.03%]
以4-羟基胆固醇/胆固醇比值作为生物标志物的CYP3A相关单核苷酸多态性的候选基因研究：在日本人群中的一项研究
Ryota Tanaka,Yosuke Suzuki,Teruhide Koyama et al.
Ryota Tanaka et al.
Purpose: CYP3A4 and CYP3A5 are major drug‑metabolizing enzymes that require electrons supplied by P450 oxidoreductase (POR) for catalytic cycle. CYP3A expression is regulated by the nuclear receptors; constitutive andros...
Antimicrobial-induced hyponatremia: pathophysiological mechanisms, implicated agents, and clinical management strategies [0.03%]
抗菌药物所致低钠血症：发病机制、相关药物及临床处理策略
Tianqi Liu,Ruixue Li,Wenfeng Xu et al.
Tianqi Liu et al.
Background: Hyponatremia is a prevalent and serious electrolyte disorder affecting approximately 20% of hospitalized patients, significantly increasing morbidity and mortality. While common causes are well-documented, ant...