Short-term effect of rosuvastatin versus atorvastatin on the corrected QT interval: a target trial emulation [0.03%]
Xin Chen,Yang Liu,Wei Wei et al.
Xin Chen et al.
Objective: To estimate the short-term effect of rosuvastatin versus atorvastatin on the corrected QT interval (QTc) by emulating a published randomized controlled trial (RCT) using electronic health record (EHR) data, and...
The impact of denosumab and calcitriol on asthma risk and lung function: a drug target mendelian randomization study [0.03%]
Zehua Jiang,Maosen Zhang,Maolan Wu et al.
Zehua Jiang et al.
Background: Osteoporosis and asthma are prevalent chronic conditions that significantly impact public health. Inflammatory cell merging, leading to reduced bone density, increases the risk of fractures, while asthma is a ...
Patricia Esperón,Marcelo Vital,Andrea Giletti
Patricia Esperón
Purpose: Methotrexate (MTX) is a long-standing drug used to treat leukemia (at high doses to inhibit DNA/RNA synthesis) and rheumatoid arthritis (at low doses for anti-inflammatory effects). Its characteristic narrow ther...
Lina-Maria Nordvall,Bo Rolander,Maria Larsson et al.
Lina-Maria Nordvall et al.
Purpose: To evaluate the possible influence of gender and specialty on adverse drug reaction (ADR) reporting among physicians before and after the COVID-19 pandemic. ...
Observational Study
European journal of clinical pharmacology. 2026 May 8;82(6):146. DOI:10.1007/s00228-026-04077-9 2026
Association between anticholinergic and sedative medications and physical functioning: data from the Canadian longitudinal study on aging (CLSA) [0.03%]
Keren Pelen,Patrick Boissy,Karina Lebel et al.
Keren Pelen et al.
Purpose: The cumulative use of anticholinergic and sedative medications has been associated with lower physical function in older adults. This study aimed to identify which physical function attributes are most impacted i...
The efficacy and safety of pentoxifylline in the treatment of chronic kidney disease: a systematic review and meta-analysis [0.03%]
Yanfang Xu,Feijie Xu,Wenting Shen
Yanfang Xu
Purpose: This research sought to systematically evaluate the effects of pentoxifylline on renal function, anemia parameters, inflammatory status, and safety among individuals with chronic kidney disease (CKD). ...
Exploring the long-term hydroxychloroquine's effects on COVID-19 outcomes in patients with autoimmune diseases: a systematic review and meta-analysis [0.03%]
Heba M Amal,Amr Maher Galal Mohamed,Mona Osman Abdel-Halim et al.
Heba M Amal et al.
Background: Hydroxychloroquine (HCQ) usage in COVID patients was a popular topic of study, especially during the first wave of the pandemic. However, the long-term impact of HCQ therapy on infected COVID-19 patients remai...
Claudia Erika Delgado-Espinoza,Rosa M Antonijoan,María Jose Martínez-Zapata
Claudia Erika Delgado-Espinoza
Purpose: This study aimed to describe the role and perceptions of clinical pharmacologists (CPs) in conducting economic evaluations of health technologies within the Spanish National Health System from a healthcare provid...
Efficacy of botulinum toxin type a for treating chronic low back pain: a systematic review and metanalysis [0.03%]
Bharath Kumar G,Mantu Jain,Bikash Ranjan Meher et al.
Bharath Kumar G et al.
Background: Chronic low back pain (CLBP) is a leading cause of pain and disability worldwide. Most cases are nonspecific, lacking a clear pathological cause, and management remains challenging. Botulinum toxin type A (BoN...
Effects of hypoxia-inducible factor prolyl hydroxylase inhibitors on lipid profiles in patients with chronic kidney disease: a systematic review and meta-analysis [0.03%]
Yun-Hui Huang,Yu-Han Huang,Tzu-Rong Peng et al.
Yun-Hui Huang et al.
Background: Hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) are novel oral agents for treating anemia in chronic kidney disease (CKD), with potential effects on lipid modulation. We aimed to systematical...