Efficacy and safety of oliceridine versus sufentanil in perioperative anesthesia and analgesia: a systematic review and meta-analysis with trial sequential analysis [0.03%]
口服.oliceridine与舒芬太尼在围手术期麻醉和镇痛中的有效性和安全性：系统评价和meta分析及试验序贯分析
Munder Lateiresh,Ayham Qatza,Engy Elkoury et al.
Munder Lateiresh et al.
Background: Perioperative pain management is a significant challenge when using conventional µ opioid agonists, which often require careful balancing of efficacy and safety. Oliceridine, a G-protein-biased µ-opioid rece...
Cognitive function in the context of pharmacogenetic CYP2D6 variability and anticholinergic burden in older adults - results from the ActiFE study [0.03%]
药代遗传学CYP2D6变异和抗胆碱能负荷在老年人认知功能中的作用——来自ActiFE研究的结果
Linda Lorenz,Judith Berres,Michael D Denkinger et al.
Linda Lorenz et al.
Purpose: To investigate the role of CYP2D6 and its pharmacogenetic variability in the association between anticholinergic burden and cognitive function in older adults. ...
Association between venetoclax concentration and febrile neutropenia in acute leukemia: a retrospective analysis [0.03%]
维奈克拉浓度与急性白血病发热性中性粒细胞减少症之间的关系：一项回顾性分析
Yuting Yan,Jin Sun,Yujiao Guo et al.
Yuting Yan et al.
Purpose: Venetoclax, a selective BCL-2 inhibitor, demonstrates efficacy in acute leukemia (AL) but variable pharmacokinetics. Therapeutic drug monitoring (TDM) may provide valuable pharmacologic insights for optimizing ve...
Cardiovascular safety of psilocybin in psychiatric practice: a narrative review [0.03%]
心理治疗中裸盖菇素的心血管安全性：综述文章
Lukasz Szarpak,Michal Pruc,Damian Swieczkowski et al.
Lukasz Szarpak et al.
Purpose: Psilocybin-assisted interventions are moving from efficacy trials toward psychiatric implementation. Cardiovascular interpretation is central to this transition because trial participants are generally medically ...
Hydroxychloroquine in pregnancy: therapeutic applications, mechanisms of action, and safety - a narrative review [0.03%]
羟氯喹在妊娠期的应用、作用机制及安全性——叙述性综述
Ameena Kadar K A,Hanna T S,Raima Nazar et al.
Ameena Kadar K A et al.
Background: Hydroxychloroquine (HCQ), a 4-aminoquinoline originally developed as an antimalarial, is widely used as an immunomodulatory therapy in rheumatic diseases during pregnancy. It is recommended for women with Syst...
Population pharmacokinetic modeling of amisulpride drug interactions and a transporter binding analysis [0.03%]
氨基磺吡啶药物相互作用的群体药代动力学模型及转运蛋白结合分析
Tongying Gan,Chang Liu,Bixuan Wu
Tongying Gan
Purpose: The combination of amisulpride and metformin is common in schizophrenia, but their potential drug-drug interaction has been largely overlooked, despite both drugs being prototypical substrates for renal eliminati...
Effect of glucocorticoids on smell sensation in patients with non-traumatic olfactory disorders: a systematic review and meta-analysis [0.03%]
糖皮质激素对非创伤性嗅觉障碍患者嗅觉感觉的影响：系统评价和-meta-分析
Sajjad Salimi,Shahin Amiri,Seyed Amir Karimi et al.
Sajjad Salimi et al.
Background: The efficacy of glucocorticoids (GCs) for treating non-traumatic olfactory disorders (ODs) remains controversial, with existing meta-analyses showing inconsistent results, largely due to variations in included...
A novel topical nitroglycerin-lidocaine combination for procedural pain management and rapid cannulation in neonates: results from a randomized controlled clinical trial [0.03%]
硝酸甘油利多卡因新型联合外用制剂在新生儿程序性疼痛管理及快速置管中的临床疗效：一项随机对照试验
Fatemeh Saghafi,Farhad Mohammadi,Mohadesah Esmaeili et al.
Fatemeh Saghafi et al.
Introduction: Venipuncture is a common and painful procedure in neonates. Sweet solutions (sucrose and glucose) are recommended and widely used as standard care for reducing neonatal procedural pain. Topical local anesthe...
Randomized Controlled Trial
European journal of clinical pharmacology. 2026 Jul 25;82(8):218. DOI:10.1007/s00228-026-04146-z 2026
Most COVID-19 vaccine adverse events detected within 48 hours in Ethiopia: implications for cohort event monitoring efficiency in resource-limited settings [0.03%]
埃塞俄比亚大多数新冠疫苗不良事件在接种后48小时内被发现：资源匮乏地区队列事件监测效率的启示
Tigist Dires Gebreyesus,Teshita Shute,Asnakech Alemu et al.
Tigist Dires Gebreyesus et al.
Background: The World Health Organization recommends cohort event monitoring with a 30-day follow-up period for vaccine safety surveillance in low- and middle-income countries (LMICs). However, in resource-limited setting...