A phase I study assessing the safety, tolerability, immunogenicity, and low-density lipoprotein cholesterol-lowering activity of immunotherapeutics targeting PCSK9 [0.03%]
针对PCSK9免疫治疗性药物的安全性、耐受性、免疫原性和低密度脂蛋白胆固醇降低作用Ⅰ期临床试验评估研究
Markus Zeitlinger,Martin Bauer,Roman Reindl-Schwaighofer et al.
Markus Zeitlinger et al.
Purpose: AT04A and AT06A are two AFFITOPE® peptide vaccine candidates being developed for the treatment of hypercholesterolemia by inducing proprotein convertase subtilisin/kexin type 9 (PCSK9)-specific antibodies. This ...
Direct oral anticoagulant safety during breastfeeding: a narrative review [0.03%]
直接口服抗凝药在母乳喂养期间的安全性：叙述性综述
Maryam Daei,Hossein Khalili,Zinat Heidari
Maryam Daei
Purpose: There are limited data regarding the safety of direct oral anticoagulants (DOACs) during breastfeeding. The aim of the present study is to investigate the extent of excretion of DOACs into human milk according to...
Effectiveness of fondaparinux vs unfractionated heparin following percutaneous coronary intervention in survivors of out-of-hospital cardiac arrest due to acute myocardial infarction [0.03%]
替奈帕格与未分级肝素在心源性院外心脏骤停行冠脉介入治疗后的疗效比较：急性心肌梗死幸存者中的疗效分析
Leonardo De Luca,Massimo Uguccioni,Enrico Natale et al.
Leonardo De Luca et al.
Aim: There is no specific evidence on the antithrombotic management of survivors of out-of-hospital cardiac arrest (OHCA) due to acute myocardial infarction (AMI). We sought to compare the short-term outcome of unfraction...
Comparing the clinical outcomes across different sodium/glucose cotransporter 2 (SGLT2) inhibitors in heart failure patients: a systematic review and network meta-analysis of randomized controlled trials [0.03%]
不同钠葡萄糖共转运蛋白2(SGLT2)抑制剂在心力衰竭患者中的临床疗效比较：随机对照试验的系统评价和网状Meta分析
Yao Hao Teo,Celine Shuen Yin Yoong,Nicholas L Syn et al.
Yao Hao Teo et al.
Purpose: Empagliflozin, dapagliflozin, canagliflozin, and ertugliflozin have been shown in randomized controlled trials to improve cardiovascular, metabolic, and renal outcomes in heart failure patients. To date, there ha...
Trends and patterns in EU(7)-PIM prescribing to elderly patients in Germany [0.03%]
德国老年患者EU（7）-PIM处方的倾向及规律
Iva Selke Krulichová,Gisbert W Selke,Petra A Thürmann
Iva Selke Krulichová
Purpose: The aim of this study was to explore patterns and long-term development in prescribing potentially inappropriate medication (PIM) according to the EU(7)-PIM list to elderly patients in Germany. ...
Observational Study
European journal of clinical pharmacology. 2021 Oct;77(10):1553-1561. DOI:10.1007/s00228-021-03148-3 2021
Torsade de pointes associated with chloroquine, hydroxychloroquine, and azithromycin: a retrospective analysis of individual case safety reports from VigiBase [0.03%]
基于VigiBase数据库的氯喹、羟氯喹和阿奇霉素致尖端扭转性室速病例报道回顾分析
Diego Macías Saint-Gerons,Rafael Tabarés-Seisdedos
Diego Macías Saint-Gerons
Purpose: To analyze the cases of torsade de pointes (TdP) and related symptoms reported in association with chloroquine (CQ), hydroxychloroquine (HCQ), and azithromycin (AZT) to the World Health Organization (WHO) global ...
Drugs and Dupuytren's disease: a pharmacovigilance study in VigiBase® [0.03%]
药物与Dupuytren氏病：VigiBase®中的药物警戒研究
Jean-Louis Montastruc,Julia Guion-Firmin,Claire de Canecaude et al.
Jean-Louis Montastruc et al.
Drug-drug interactions between vitamin K antagonists and statins: a systematic review [0.03%]
维生素K拮抗剂与他汀类药物相互作用的系统评价
Anna E Engell,Andreas L O Svendsen,Bent S Lind et al.
Anna E Engell et al.
Purpose: Concomitant use of vitamin K antagonists (VKA) and statins is frequent in cardiovascular patients. However, clinical guidelines on this drug combination are divergent. Therefore, we performed a systematic review ...
Correction to: Essentials in saline pharmacology for nasal or respiratory hygiene in times of COVID-19 [0.03%]
关于盐水药理学在COVID-19时期的鼻或呼吸道卫生中的关键点的更正原文发表日期:2020年7月6日
Suzy Huijghebaert,Levi Hoste,Guido Vanham
Suzy Huijghebaert
Johannes Heck,Benjamin Krichevsky,Dirk O Stichtenoth et al.
Johannes Heck et al.