Evaluation of drug-drug interactions of pemigatinib in healthy participants [0.03%]
评估pemigatinib与健康受试者药物-药物相互作用研究中的其他药物之间的相互作用
Tao Ji,Kevin Rockich,Noam Epstein et al.
Tao Ji et al.
Purpose: Pemigatinib (INCB054828), a potent and selective oral fibroblast growth factor receptor 1-3 inhibitor, is a Biopharmaceutical Classification System class II compound with good permeability and pH-dependent solubi...
Effect of SAcubitril/Valsartan on left vEntricular ejection fraction and on the potential indication for Implantable Cardioverter Defibrillator in primary prevention: the SAVE-ICD study [0.03%]
SACCS/ valsartan对左室射血分数及一级预防植入型心律转复除颤器的影响：SAVE-ICD研究
Federico Guerra,Ernesto Ammendola,Matteo Ziacchi et al.
Federico Guerra et al.
Purpose: Sacubitril/valsartan has been associated with a positive reverse left ventricular remodelling in patients with heart failure with reduced ejection fraction (HFrEF). These patients may also benefit from an ICD imp...
Observational Study
European journal of clinical pharmacology. 2021 Dec;77(12):1835-1842. DOI:10.1007/s00228-021-03189-8 2021
Comparison of S-1-based vs. capecitabine-based adjuvant chemotherapy for patients with gastric cancer: a systematic review and meta-analysis [0.03%]
一项系统性回顾和元分析：胃癌患者接受以S-1为基础的辅助化疗与卡培他滨为基础的辅助化疗的比较研究
Qingqian Zhang,Yue Qian,Ying Yin
Qingqian Zhang
Background: S-1-based and capecitabine-based adjuvant treatments are proved efficacious for patients with gastric cancer, but conventional meta-analyses of the direct comparisons between two alternative adjuvant regimens ...
Successful deprescribing of proton pump inhibitors with a patient-centered process: the DESPIBP Project [0.03%]
以患者为中心的成功停用质子泵抑制剂项目：DESPIBP项目的经验
Lamuela L J Calvo,P García Cámara,M Llorente Barrio et al.
Lamuela L J Calvo et al.
Background: Proton-pump inhibitors (PPIs) are among the most frequently prescribed drugs, but they are being overprescribed. Objective: ...
Serum concentrations of antidepressants, antipsychotics, and antiepileptics over the bariatric surgery procedure [0.03%]
减肥手术过程中抗抑郁药、抗精神病药和抗癫痫药的血清浓度变化规律
Susanna M Wallerstedt,Karin Nylén,Magnus A B Axelsson
Susanna M Wallerstedt
Purpose: As a substantial proportion of bariatric surgery patients use psychotropic/antiepileptic drugs, we investigated the impact of this procedure on serum concentrations. ...
Pharmacoepidemiological methods for computing the duration of pharmacological prescriptions using secondary data sources [0.03%]
基于次要数据源的计算药物处方周期的药物流行病学方法研究
Marianne Meaidi,Henrik Støvring,Klaus Rostgaard et al.
Marianne Meaidi et al.
Purpose: In pharmacoepidemiology, correctly defining the exposure period of pharmacological treatment is a challenging step when information on the time in treatment is missing or incomplete. ...
Population pharmacokinetics and exposure-response relationship of trastuzumab and bevacizumab in early-stage breast cancer [0.03%]
曲妥珠单抗和贝伐珠单抗早期乳腺癌患者的群体药代动力学及暴露-效应关系研究
A Petitcollin,N Azzopardi,J Y Pierga et al.
A Petitcollin et al.
Aims: To describe the sources of interindividual variability of bevacizumab and trastuzumab pharmacokinetics in early-stage breast cancer, and to study the relationship between exposure and both early clinical response an...
Randomized Controlled Trial
European journal of clinical pharmacology. 2021 Dec;77(12):1861-1873. DOI:10.1007/s00228-021-03179-w 2021
Bo Xu,Gaorui Tang,Zhen Chen
Bo Xu
Purpose: Patients with type 1 diabetes mellitus (T1DM) receiving insulin therapy commonly suffer from insulin-mediated hypoglycemia and require glucagon for glycemic control to achieve normal plasma glucose (PG) levels. S...
Comparative study evaluating antihistamine versus leukotriene receptor antagonist as adjuvant therapy for rheumatoid arthritis [0.03%]
抗组胺药与白三烯受体拮抗药作为类风湿关节炎辅助治疗的比较研究
Tarek Mohamed Mostafa,Sahar Kamal Hegazy,Salwa El-Morsy Abd El-Ghany et al.
Tarek Mohamed Mostafa et al.
Purpose: Investigating the efficacy and safety of rupatadine (RUP) versus montelukast (MON) as adjuvant therapy for patients with rheumatoid arthritis (RA). ...
Randomized Controlled Trial
European journal of clinical pharmacology. 2021 Dec;77(12):1825-1834. DOI:10.1007/s00228-021-03181-2 2021
Circulating microRNA-30a-5p, microRNA-101-3p, microRNA-140-3p and microRNA-141-3p as potential biomarkers for dexmedetomidine response in pediatric patients [0.03%]
用于儿科患者右美托咪定反应的潜在生物标志物：循环miR-30a-5p、miR-101-3p、miR-140-3p和miR-141-3p
Xinmei Cai,Bilian Li,Wei Wei et al.
Xinmei Cai et al.
Purpose: The aim of this study was to investigate the expression levels of plasma miR-30a-5p, miR-101-3p, miR-140-3p and miR-141-3p and their relationship to dexmedetomidine efficacy and adverse effects in pediatric patie...