The impact of denosumab and calcitriol on asthma risk and lung function: a drug target mendelian randomization study [0.03%]
关于denosumab和calcitriol对哮喘风险及肺功能影响的药物靶标孟德尔随机化研究
Zehua Jiang,Maosen Zhang,Maolan Wu et al.
Zehua Jiang et al.
Background: Osteoporosis and asthma are prevalent chronic conditions that significantly impact public health. Inflammatory cell merging, leading to reduced bone density, increases the risk of fractures, while asthma is a ...
The impact of gene polymorphisms on the response of methotrexate-based treatments [0.03%]
基因多态性对甲氨蝶呤为基础的治疗疗效影响的研究进展
Patricia Esperón,Marcelo Vital,Andrea Giletti
Patricia Esperón
Purpose: Methotrexate (MTX) is a long-standing drug used to treat leukemia (at high doses to inhibit DNA/RNA synthesis) and rheumatoid arthritis (at low doses for anti-inflammatory effects). Its characteristic narrow ther...
Physicians' gender and specialty in relation to adverse drug reaction reporting in Sweden [0.03%]
瑞典医生的性别和专业与不良药物反应报告的关系
Lina-Maria Nordvall,Bo Rolander,Maria Larsson et al.
Lina-Maria Nordvall et al.
Purpose: To evaluate the possible influence of gender and specialty on adverse drug reaction (ADR) reporting among physicians before and after the COVID-19 pandemic. ...
Observational Study
European journal of clinical pharmacology. 2026 May 8;82(6):146. DOI:10.1007/s00228-026-04077-9 2026
Association between anticholinergic and sedative medications and physical functioning: data from the Canadian longitudinal study on aging (CLSA) [0.03%]
抗胆碱能和镇静类药物与人体机能之间的关系：加拿大老年人纵向研究数据的分析
Keren Pelen,Patrick Boissy,Karina Lebel et al.
Keren Pelen et al.
Purpose: The cumulative use of anticholinergic and sedative medications has been associated with lower physical function in older adults. This study aimed to identify which physical function attributes are most impacted i...
The efficacy and safety of pentoxifylline in the treatment of chronic kidney disease: a systematic review and meta-analysis [0.03%]
氨茶碱治疗慢性肾脏疾病有效性和安全性的系统评价和meta分析
Yanfang Xu,Feijie Xu,Wenting Shen
Yanfang Xu
Purpose: This research sought to systematically evaluate the effects of pentoxifylline on renal function, anemia parameters, inflammatory status, and safety among individuals with chronic kidney disease (CKD). ...
Exploring the long-term hydroxychloroquine's effects on COVID-19 outcomes in patients with autoimmune diseases: a systematic review and meta-analysis [0.03%]
自身免疫性疾病患者的长期羟氯喹对COVID-19结局的影响：系统综述和meta分析
Heba M Amal,Amr Maher Galal Mohamed,Mona Osman Abdel-Halim et al.
Heba M Amal et al.
Background: Hydroxychloroquine (HCQ) usage in COVID patients was a popular topic of study, especially during the first wave of the pandemic. However, the long-term impact of HCQ therapy on infected COVID-19 patients remai...
The role of Spanish clinical pharmacologists in economic evaluations of health technologies [0.03%]
西班牙临床药理学家在健康技术经济评估中的作用
Claudia Erika Delgado-Espinoza,Rosa M Antonijoan,María Jose Martínez-Zapata
Claudia Erika Delgado-Espinoza
Purpose: This study aimed to describe the role and perceptions of clinical pharmacologists (CPs) in conducting economic evaluations of health technologies within the Spanish National Health System from a healthcare provid...
Efficacy of botulinum toxin type a for treating chronic low back pain: a systematic review and metanalysis [0.03%]
肉毒杆菌素A治疗慢性下背痛疗效的系统评价和网状Meta分析
Bharath Kumar G,Mantu Jain,Bikash Ranjan Meher et al.
Bharath Kumar G et al.
Background: Chronic low back pain (CLBP) is a leading cause of pain and disability worldwide. Most cases are nonspecific, lacking a clear pathological cause, and management remains challenging. Botulinum toxin type A (BoN...
Effects of hypoxia-inducible factor prolyl hydroxylase inhibitors on lipid profiles in patients with chronic kidney disease: a systematic review and meta-analysis [0.03%]
缺氧诱导因子脯氨酸羟化酶抑制剂对慢性肾脏病患者脂质谱影响的系统评价和Meta分析
Yun-Hui Huang,Yu-Han Huang,Tzu-Rong Peng et al.
Yun-Hui Huang et al.
Background: Hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) are novel oral agents for treating anemia in chronic kidney disease (CKD), with potential effects on lipid modulation. We aimed to systematical...
Examining the risk of neurotoxicity in patients who receive unadjusted doses of oral beta-lactams in renal insufficiency: a retrospective cohort study [0.03%]
肾功能不全患者接受未根据肾功能调整剂量的口服β-内酰胺类药物治疗的风险：一项回顾性队列研究
Noah Zlotnik,Philip W Lam,Jennifer Lo et al.
Noah Zlotnik et al.
Background: In patients with reduced renal function, drug monographs recommend reduced doses of oral beta-lactams. However, dose reductions could result in suboptimal pharmacokinetic-pharmacodynamic target attainment, com...