Vincent Spegg,Matthias Altmeyer
Vincent Spegg
Genome stability is key for healthy cells in healthy organisms, and deregulated maintenance of genome integrity is a hallmark of aging and of age-associated diseases including cancer and neurodegeneration. To maintain a stable genome, genom...
Cross-species chromosome painting and repetitive DNA mapping illuminate the karyotype evolution in true crocodiles (Crocodylidae) [0.03%]
跨物种染色体绘画和重复DNA映射阐明真鳄类（Crocodylidae）染色体进化变迁
Vanessa Sales-Oliveira,Marie Altmanová,Václav Gvoždík et al.
Vanessa Sales-Oliveira et al.
Crocodilians have maintained very similar karyotype structures and diploid chromosome numbers for around 100 million years, with only minor variations in collinearity. Why this karyotype structure has largely stayed unaltered for so long is...
Looping out of control: R-loops in transcription-replication conflict [0.03%]
失控的发卡结构 RNA-DNA 杂交链在转录-复制冲突中的作用
Charanya Kumar,Dirk Remus
Charanya Kumar
Transcription-replication conflict is a major cause of replication stress that arises when replication forks collide with the transcription machinery. Replication fork stalling at sites of transcription compromises chromosome replication fi...
New voices in epigenetics [0.03%]
表观遗传学的新进展
Genevieve Almouzni,Tom Misteli,Yamini Dalal
Genevieve Almouzni
Centromeric and pericentric transcription and transcripts: their intricate relationships, regulation, and functions [0.03%]
着丝粒和近端序列区域的转录及其转录本的复杂关系、调控及功能
Jing Zhu,Qiao Guo,Minjun Choi et al.
Jing Zhu et al.
Centromeres are no longer considered to be silent. Both centromeric and pericentric transcription have been discovered, and their RNA transcripts have been characterized and probed for functions in numerous monocentric model organisms recen...
Germaine Karam,Antoine Molaro
Germaine Karam
During mammalian reproduction, germ cell chromatin packaging is key to prepare parental genomes for fertilization and to initiate embryonic development. While chromatin modifications such as DNA methylation and histone post-translational mo...
Increased genome size is caused by heterochromatin addition in two non-related bat species, Hesperoptenus doriae and Philetor brachypterus (Vespertilionidae, Chiroptera, Mammalia) [0.03%]
异染色质增加导致两种不相关的蝙蝠物种基因组大小增加：Hesperoptenus doriae 和 Philetor brachypterus（Vespertilionidae，Chiroptera，Mammalia）
Marianne Volleth,Johann Greilhuber,Klaus-Gerhard Heller et al.
Marianne Volleth et al.
The average genome size (GS) of bats, which are the only mammals capable of powered flight, is approximately 18% smaller than that of closely related mammalian orders. The low nuclear DNA content of Chiroptera is comparable to that of birds...
Genetic heterogeneity in p53-null leukemia increases transiently with spindle assembly checkpoint inhibition and is not rescued by p53 [0.03%]
p53缺失型白血病的小鼠模型中检查点抑制暂时增加了遗传异质性且不能被p53挽救治疗降低该异质性
Mai Wang,Steven Phan,Brandon H Hayes et al.
Mai Wang et al.
Chromosome gains or losses often lead to copy number variations (CNV) and loss of heterozygosity (LOH). Both quantities are low in hematologic "liquid" cancers versus solid tumors in data of The Cancer Genome Atlas (TCGA) that also shows th...
The regulation of Tfh cell differentiation by β-hydroxybutyrylation modification of transcription factor Bcl6 [0.03%]
β-羟基丁酰化修饰转录因子Bcl6调控Tfh细胞分化机制研究
Jingtian Guo,Yimeng Wang,Lei Tang et al.
Jingtian Guo et al.
Transcriptional repressor B cell lymphoma 6 (Bcl6) is a major transcription factor involved in Tfh cell differentiation and germinal center response, which is regulated by a variety of biological processes. However, the functional impact of...
Modeling of covalent modifications of histones to estimate the binding affinity [0.03%]
用于估算结合亲和力的组蛋白共价修饰模型化研究
Ali Aslhashemi,Mahdi Rezaei Karamati,Hossein Motavalli et al.
Ali Aslhashemi et al.
Covalent histone modifications such as methylation, acetylation, phosphorylation, and other epigenetic modifications of the chromatin play an essential role in regulating eukaryotic cells of which most of these reactions are catalyzed by th...