Pannexin-1 is present in a subpopulation of bovine milk-derived small extracellular vesicles [0.03%]
存在于牛乳小细胞外囊泡亚群中的pannexin-1蛋白质
Md Ruhul Amin,Spencer R Marsh,Claire Beard et al.
Md Ruhul Amin et al.
Pannexin-1 (Panx1) is a large-pore membrane channel protein implicated in diverse physiological and pathological processes, yet its presence in extracellular vesicles has not been fully characterized. In this study, we investigated small ex...
Rab24 protein levels show dynamic changes in mouse tissues and human cancers [0.03%]
Rab24蛋白在小鼠组织和人类肿瘤中的表达量变化规律不同
H G Mauricio Ramm,Farhad Ahmed,Sadaf Fazeli et al.
H G Mauricio Ramm et al.
Rab24 is an unusual member of the Rab family of small GTPases, implicated in autophagy, endocytosis and cell division. In order to elucidate possible organ and age-specific roles of Rab24, we investigated tissue-specific levels of Rab24 in ...
Phenothiazine alleviates cisplatin-mediated acute kidney injury by inhibiting ferroptosis [0.03%]
吩噻嗪通过抑制铁死亡来缓解顺铂引起的急性肾损伤
Xue Sun,Yang Chen,Chong Wei et al.
Xue Sun et al.
Cisplatin is a first-line chemotherapeutic agent for various tumors; however, its clinical utility is substantially limited by the risk of cisplatin-induced acute kidney injury (AKI). Since inhibition of ferroptosis effectively mitigates ci...
Pannexins in the heart: cell-specific expression and contributions to disease [0.03%]
心脏中的pannexin：特定细胞的表达和对疾病的影响
Mark C Renton,Meghan W Sedovy,Amanda Reynolds et al.
Mark C Renton et al.
Heart disease is the leading cause of death globally. Although modern interventions have dramatically reduced the morbidity and mortality of heart disease, the lack of knowledge of key underlying mechanisms has limited the development of ef...
Autonomic neural control of motor activity in the intestine of freshwater barramundi (Lates calcarifer) [0.03%]
淡水巨石斑鱼(Lates calcarifer)肠神经系统对运动活动的自主神经控制
Hayley Rhodes,Lee Travis,Timothy J Hibberd et al.
Hayley Rhodes et al.
Evolutionary pressure on the gastrointestinal (GI) tract of teleost fish differs substantially from those of terrestrial animals. The intestine is a pivotal organ in teleost, for maintaining osmotic balance against the surrounding aquatic e...
Organelles with screening pigment in the supporting cells of the retina of the camera-like eye of the gastropod Helix pomatia [0.03%]
鲍鱼Helix pomatia摄像眼视网膜支持细胞中的具筛分色素的细胞器
Irina P Shepeleva
Irina P Shepeleva
For the first time, the morphological properties of organelles with screening pigment in the supporting cells of the non-optic part and the peripheral and central region of the optic part of the retina of the camera-like eye of the gastropo...
Meckel's cartilage midsegment: spatiotemporal dynamics and osteogenic role in mice [0.03%]
鼠梅克尔软骨中段的时空动态及成骨作用
Qi Sun,Cheng Li,Lizhu Yin et al.
Qi Sun et al.
Meckel's cartilage is a transient yet essential structure in the development of the mammalian mandible, with its midsegment undergoing distinct degradation and potentially contributing to bone formation. However, the mechanisms regulating i...
Aldosterone induced by chronic stress promotes pancreatic steatosis in young male rats [0.03%]
慢性应激诱导的醛固酮促进年轻雄性大鼠胰腺脂肪变性
Eliut Pérez-Sánchez,Cristhian Neftaly Sánchez-Solís,Sumiko Morimoto et al.
Eliut Pérez-Sánchez et al.
Aldosterone, a stress-related hormone, may contribute to pancreatic dysfunction. Its role in pancreatic physiology, inflammation, and fibrosis remains poorly understood. This study aimed to evaluate the effects of aldosterone on pancreatic ...
Panx1 and drug discovery: from non-specific inhibitors to tailored drug compounds [0.03%]
连接蛋白1和药物发现：从非特异性抑制剂到靶向药化合物
Michael Kohr,Carola Meier
Michael Kohr
Pannexin (Panx)-1-mediated ATP release has been associated with a broad range of pathological conditions. Conversely, the use of Panx1-inhibitors has shown promising results in the medication of diseases, such as neuroinflammation, melanoma...
Characterization of bovine oviductal organoids: Polarity, cryopreservation, hormonal stimulation, and extracellular vesicles [0.03%]
牛输卵管类器官的特征：极性、冻存、激素刺激和细胞外囊泡
Riley E Thompson-Brandhagen,Mindy A Meyers,Brandi Dunn et al.
Riley E Thompson-Brandhagen et al.
The oviduct is an important reproductive organ that fosters fertilization and early embryo development in mammals. With growing utilization of assisted reproductive technologies (ARTs) in animal agriculture, recent advancements in cell cult...