Histological, ultrastructural, and single-cell profiling reveal immune-mediated remodeling in gallbladder inflammation [0.03%]
组织学、电镜及单细胞转录组分析揭示胆囊炎免疫重塑特征
Dmytro Vlasenko,Andrea Maccagno,Adriano Sanna et al.
Dmytro Vlasenko et al.
Gallbladder inflammation comprises distinct pathological entities, including acute, neutrophil-dominated injury and chronic, fibrotic remodeling. This study aimed to define the cellular and structural programs that characterize these two in...
Proteolytic dysregulation in the skin: insight from rare monogenic skin diseases [0.03%]
来自罕见单基因皮肤病的见解：皮肤蛋白酶失调
Zhongtao Li,Sheng Wang,Diana C Blaydon et al.
Zhongtao Li et al.
Proteases are essential enzymes that, through the breakdown of proteins, regulate many aspects of tissue homeostasis including barrier function, cellular signaling, and tissue repair mechanisms in organisms. Disease gene discovery in a numb...
Brain peptides in Alzheimer's disease - pathophysiology and therapeutic advances [0.03%]
阿尔茨海默病的脑肽研究-病理生理和治疗进展
Sonu Pahal,Arushi Gupta,Vivek Kumar et al.
Sonu Pahal et al.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, memory impairment, and hallmark neuropathological features, including extracellular amyloid-β (Aβ) plaques and intracellular neurofib...
Three-dimensional structure and epithelial changes of the piriform sinus fistula in cotton rats [0.03%]
棉鼠梨状窝瘘的三维结构及上皮改变
Teppei Nakamura,Marina Hosotani,Osamu Ichii et al.
Teppei Nakamura et al.
Piriform sinus fistula (PSF) is a rare congenital anomaly derived from the third or fourth pharyngeal pouch. However, its developmental mechanisms remain poorly understood owing to the absence of suitable animal models. Cotton rats (Sigmodo...
TGFβ signaling regulates Col15a1 expression in fenestrated endothelial cells of the rat pituitary [0.03%]
TGFβ信号调节大鼠垂体窗孔内皮细胞中Col15a1的表达
Takashi Nakakura,Takehiro Tsukada,Takeshi Suzuki
Takashi Nakakura
Fenestrated capillaries in the anterior lobe (AL) of the pituitary gland are specialized for efficient hormone exchange and are surrounded by extracellular matrix-rich basement membranes (BMs). Although several collagens have been implicate...
Interleukin-4 changes the transcriptome, ECM-associated components and function of mare endometrial fibroblast: Insights from healthy and fibrotic cells [0.03%]
白细胞介素4改变了母马子宫内膜正常及纤维化成纤维细胞的转录组以及基底膜相关组分和功能
Anna Wójtowicz,Agnieszka Sadowska,Kamil Myszczyński et al.
Anna Wójtowicz et al.
Fibrosis remains incompletely understood, particularly in terms of how immune mediators shape stromal programs. We used a spontaneous large‑animal model-endometrosis (equine endometrial fibrosis) to define how interleukin‑4 (IL‑4) reprog...
MG132 facilitates dentin regeneration by modulating inflammation and odontoblast differentiation [0.03%]
MG132通过调节炎症和成牙本质细胞分化促进牙本质再生
Bandana Rana,Elina Pokharel,Je-Hee Jang et al.
Bandana Rana et al.
Although regeneration of the dentin-pulp complex is a key goal in endodontic therapy, pulpal inflammation can impede effective tissue repair and sustained healing. Recent studies suggest that proteasome inhibitors can modulate key cellular ...
The relationship between Connexin 43 (Cx43) and partner protein, human discs large homologue-1 (Dlg1) during wound closure in keratinocytes [0.03%]
角质形成细胞伤口愈合过程中缝隙蛋白43（Connexin 43，Cx43）与人盘状同源物1蛋白（discs large homologue-1，Dlg1）相互作用关系的研究
Harry Scott,Li Dong,Andrew Stevenson et al.
Harry Scott et al.
Plasma membrane gap junctions, formed by connexin proteins, are responsible for direct intercellular communication between adjacent cells by allowing the exchange of ions, metabolites, secondary messengers and microRNAs. Connexin 43 (Cx43) ...
Hydrogen peroxide reduces Cx40, Cx43, and Cx45 gap junction function [0.03%]
过氧化氢减少Cx40、Cx43和Cx45间隙连接功能
Yi X Li,Donglin Bai
Yi X Li
Cardiac gap junctions (GJs), formed by connexin 40 (Cx40), Cx43, and Cx45, are essential for the rapid propagation of action potentials in the myocardium, which synchronizes the atria and ventricles to produce a rhythmic heartbeat. Oxidativ...
Significant expression of prosaposin in the intermediate lobe of mouse pituitary gland [0.03%]
小鼠垂体中间叶富含前脑啡肽原的表达
Aimi Fuyuki,Masashi Higuchi,Takeshi Homma et al.
Aimi Fuyuki et al.
Prosaposin (PSAP) is a highly conserved glycoprotein in vertebrates. It is known to be transported into lysosomes and facilitates lysosomal hydrolysis. In addition, PSAP is secreted in various body fluids, including serum. Extracellular PSA...