Zebrafish Models for Skeletal and Extraskeletal Osteogenesis Imperfecta Features: Unveiling Pathophysiology and Paving the Way for Drug Discovery [0.03%]
斑马鱼骨骼和骨外成骨不全症特征模型：揭示病理生理学并为药物发现铺平道路
Cecilia Masiero,Carla Aresi,Antonella Forlino et al.
Cecilia Masiero et al.
In the last decades, the easy genetic manipulation, the external fertilization, the high percentage of homology with human genes and the reduced husbandry costs compared to rodents, made zebrafish a valid model for studying human diseases a...
Preventing OsteoPorosis in Spinal Cord Injury (POPSCI) Study-Early Zoledronic Acid Infusion in Patients with Acute Spinal Cord Injury [0.03%]
预防脊髓损伤患者骨质疏松的早期临床研究（POPSCI研究）- 伊班磷酸钠治疗急性期脊髓损伤患者
Shejil Kumar,Jean Doyle,Cameron Wood et al.
Shejil Kumar et al.
Accelerated sub-lesional bone loss is common in the first 2-3 years after traumatic spinal cord injury (TSCI), particularly in the distal femur and proximal tibia. Few studies have explored efficacy of antiresorptives for acute bone loss pr...
Early-Onset Osteoporosis: Molecular Analysis in Large Cohort and Focus on the PLS3 Gene [0.03%]
早发性骨质疏松症的大规模队列分子分析及PLS3基因研究聚焦
Maxence Mancini,Roland Chapurlat,Bertrand Isidor et al.
Maxence Mancini et al.
Osteoporosis is a skeletal disorder characterized by abnormal bone microarchitecture and low bone mineral density (BMD), responsible for an increased risk of fractures and skeletal fragility. It is a common pathology of the aging population...
Fermented Dairy Products, Musculoskeletal and Mental Health in Older Adults: is There Evidence to Support Benefits that go Beyond Those of Non-Fermented Dairy Products? [0.03%]
老年人群中的发酵乳制品、骨骼肌肉及心理健康：有证据表明其益处优于非发酵乳制品吗？
M Papageorgiou,M Lyrakou,A Kyriacou et al.
M Papageorgiou et al.
Fermented dairy products have recently gained popularity due to their purported health benefits, nevertheless, their role in ageing remains uncertain. This narrative review aims to evaluate evidence from observational (prospective) and inte...
Laura Ventura,Sara J E Verdonk,Lidiia Zhytnik et al.
Laura Ventura et al.
Osteogenesis imperfecta (OI) is a rare genetic disorder characterized by fragile bones and skeletal deformities. Individuals with OI may have dental abnormalities such as dentinogenesis imperfecta (DI) type I, malocclusions, and unerupted o...
Higher Plasma Copper Exposure was Adversely Associated with Skeletal Muscle Indicators in Chinese Children Aged 6-9 Years: A Cross-Sectional Study [0.03%]
中国6-9岁儿童血浆铜暴露与骨骼肌指标横断面研究及其相互作用分析
Jie Xu,Jing Lan,Qiaoting Huang et al.
Jie Xu et al.
It is unclear whether blood concentrations of copper (Cu), magnesium (Mg), and calcium (Ca) influence skeletal muscle mass and strength in children. We aimed to explore the associations between plasma Cu, Mg, and Ca and skeletal muscle indi...
Irisin Ameliorates Muscle Atrophy by Inhibiting the Upregulation of the Ubiquitin‒Proteasome System in Chronic Kidney Disease [0.03%]
鸢垂素通过抑制慢性肾脏病中蛋白酶体系统上调改善肌肉萎缩
Shiyuan Wang,Yajing Pan,Qi Pang et al.
Shiyuan Wang et al.
Muscle atrophy is a common complication of chronic kidney disease (CKD). Irisin, a novel muscle cytokine, protects against muscle atrophy, but its specific role in CKD-associated muscle atrophy requires further elucidation. Because the ubiq...
Sex-Specific Association of Clinical Parameters and Components of Femoral Bone Quality in Patients Undergoing Total Hip Arthroplasty [0.03%]
髋关节置换术患者股骨骨质各成分与临床参数的性别特异性关联分析
Assil-Ramin Alimy,Maximilian Lenard Thiessen,André Strahl et al.
Assil-Ramin Alimy et al.
Poor bone quality is a critical factor associated with an increased risk of complications after total hip arthroplasty (THA). However, no consistent recommendations have yet been established for assessing indicators of bone quality preopera...
Osteocyte Sptbn1 Deficiency Alters Cell Survival and Mechanotransduction Following Formation of Plasma Membrane Disruptions (PMD) from Mechanical Loading [0.03%]
骨细胞Sptbn1缺乏影响机械加载后血浆膜中断(PMD)形成后的细胞存活和力学信号转导
Mackenzie L Hagan,Anik Tuladhar,Kanglun Yu et al.
Mackenzie L Hagan et al.
We and others have shown that application of high-level mechanical loading promotes the formation of transient plasma membrane disruptions (PMD) which initiate mechanotransduction. We hypothesized that increasing osteocyte cell membrane fra...