Differential diagnosis of heritable and acquired osteomalacia in children: biochemical and biomaterial signatures [0.03%]
儿童遗传性和获得性骨软化症的鉴别诊断：生化和生物材料标志物
Suma Uday,Wolfgang Högler
Suma Uday
Defective mineralization of bone matrix results in osteomalacia, which universally affects the skeletal system and dentition and manifests alongside the clinically and radiologically more obvious growth plate disorder rickets in young child...
Microbes Matter: Exploring the Connection Between Infant Gut Microbiota and Bone Development [0.03%]
婴儿肠道菌群与骨骼发育之间的联系探究
Perry Caviness,Bharath K Mulakala,Oxana P Lorenzo et al.
Perry Caviness et al.
Human milk, compared to milk formula, is considered the optimal source of nutrition for infants as it can shape offspring microbiome composition, which is necessary for the production of key biomolecules that aid in development of infant ph...
Identification and Validation of Novel Lipids Linked to Bone Mineral Density Change and Fracture Risk [0.03%]
识别并验证与骨矿密度变化和骨折风险相关的新型脂质
Canchen Ma,Ziyuan Shen,Jing Tian et al.
Canchen Ma et al.
To identify and validate lipid metabolites associated with bone mineral density (BMD) change and fracture risk through integrated Mendelian randomization (MR) and observational analyses. Two-sample MR analysis was first performed to uncover...
Bone Mineral Density and Trabecular Bone Score in Children, Adolescents and Young Adults with Familial Dysautonomia [0.03%]
家族性自主神经病儿童、青少年和年轻人的骨密度和 trabecular bone score 分析
Bat El Bar-Aluma,Ronit Porges,Liana Tripto-Shkolnik et al.
Bat El Bar-Aluma et al.
Familial dysautonomia (FD) is characterized by skeletal morbidity, including osteoporosis and increased fracture risk. We aimed to assess bone mineral density (BMD) and trabecular bone score (TBS) in individuals with FD, and to explore corr...
A Mosaic PHEX Variant in Hypophosphatemic Rickets: Distinguishing Postzygotic Mutation from Sex Chromosome Aneuploidy [0.03%]
低磷性佝偻病中的PHEX镶嵌变异体：将合子后突变与性染色体非整倍体区分开来
Wu Tzen Lim,Marni Nenke,Lesley Rawlings et al.
Wu Tzen Lim et al.
Hereditary hypophosphatemic rickets, most commonly caused by X-linked dominant PHEX variants, leads to hypophosphatemia and bone mineralization defects. We identified a novel mosaic nonsense variant in the PHEX gene on the X chromosome by n...
A Systematic Review of the Effects of Bisphosphonates on Osteoblasts In Vitro [0.03%]
双膦酸盐体外作用于成骨细胞的系统性综述研究
Henrique Hadad,Laís Kawamata de Jesus,Maísa Pereira da Silva et al.
Henrique Hadad et al.
Bisphosphonates (BPs) are widely used to treat bone disorders, prevent skeletal-related events, and manage bone metastasis. These drugs are synthetic analogs of pyrophosphate and primarily function by inhibiting osteoclast activity. However...
Association of the Appendicular Skeletal Muscle Mass-to-Visceral Fat Area Ratio with Cause-Specific Mortality in Diabetes [0.03%]
糖尿病患者骨骼肌质量与内脏脂肪面积比值与特定原因死亡之间的关联研究
Shuwu Wei,Jiale Zhang,Huijuan Zheng et al.
Shuwu Wei et al.
The relationship between muscle mass and visceral fat with mortality risk in diabetes has been extensively studied. This study investigates the association between the appendicular skeletal muscle mass-to-visceral fat area ratio (SVR) and c...
Characterization of Bone Matrix Mineralization and Osteocyte Lacunar Density Unveils Microstructural Impairment at the Main Femoral Fracture-Initiating Site in Type 2 Diabetes Mellitus [0.03%]
骨基质矿化和骨细胞腔密度的特征揭示了2型糖尿病患者主要股骨骨折起始部位的微结构损伤
Aleksandar Cirovic,Jelena Jadzic,Christine Plumeyer et al.
Aleksandar Cirovic et al.
This study aimed to perform microstructural characterization of the increased fragility of human bone in type 2 diabetes mellitus (T2DM) by exploring the matrix mineralization and osteocyte lacunar density at the superolateral femoral neck-...
Lower Limb Bone Mineral Density Reduction is Closely Relative With Diabetic Peripheral Neuropathy in the Postmenopausal Women and Men Over 50 Years Old With T2DM: A cross-Sectional, Controlled Study [0.03%]
绝经后女性和超过50岁T2DM男性下肢骨密度降低与糖尿病周围神经病变密切相关：一项横断面研究
Xiaopu Lin,Xiaoming Wen,Yanting Zhou et al.
Xiaopu Lin et al.
A cross-sectional, controlled study was designed to investigate the relationship between BMD at different sites and DPN in patients with type 2 diabetes mellitus (T2DM). Nerve conduction parameters and BMD of different sites were measured. ...
Exploring the Role of FGF7 in Tumor-Induced Osteomalacia. Clinic-Pathologic Analysis in a Patient with a Sino-Nasal Phosphaturic Mesenchymal Tumor [0.03%]
FGF7在肿瘤相关性骨软化症中作用的探索及鼻窦磷摄取性基质瘤1例临床病理分析
L Colangelo,F R Di Ciommo,B Palmisano et al.
L Colangelo et al.
Tumor-induced osteomalacia (TIO) is an ultrarare paraneoplastic syndrome due to the overproduction of Fibroblast Growth Factor 23 (FGF23). Although other phosphate-regulating substances (i.e., "phosphatonins") have been demonstrated to be e...