Evaluation of Low Alkaline Phosphatase Levels in Clinical Practice: Implications for Diagnosing Hypophosphatasia [0.03%]
临床实践中低碱性磷酸酶水平的评估：诊断低碱性磷酸酶血症的意义
Gonul Buyukyilmaz,Serkan Bilge Koca,Refika Gören et al.
Gonul Buyukyilmaz et al.
Persistent low serum alkaline phosphatase (ALP) levels are crucial in identifying genetic disorders such as hypophosphatasia (HPP). This study investigates the causes of low ALP levels in children, aiming to evaluate the demographic and cli...
Quantitative Computed Tomography-Based Analysis of Bone Structure in the Surgical Neck of the Humerus during Aging in Men [0.03%]
基于定量CT的男性肱骨外科颈骨结构老龄化变化分析
Yeming Wang,Jian Li,Yutao Men et al.
Yeming Wang et al.
The changes in bone mineral density (BMD), bone structure, and bone size at the proximal humerus with aging, which can lead to fragile fractures in men, are not well understood. This study aimed to investigate age-related changes in the ske...
The Impact of Sedentary Behavior and Physical Activity on Bone Health: A Narrative Review from the Rehabilitation Working Group of the International Osteoporosis Foundation [0.03%]
久坐行为和体力活动对骨健康的影响：国际骨质疏松基金会康复工作组的叙述性综述
Olivier Bruyère,David Scott,Alexandra Papaioannou et al.
Olivier Bruyère et al.
Physical activity (PA) and sedentary behavior (SB) are two key lifestyle factors with profound implications for bone health across the lifespan. While PA is recognized for its positive effects on bone mineral density (BMD) and fracture prev...
Consensus-Based Recommendations for the Diagnosis, Treatment, and Monitoring of Hypoparathyroidism: Insights from the DACH Region [0.03%]
基于共识的低血钙症诊断、治疗和监测建议：来自德语地区国家的见解
Elena Tsourdi,Karin Amrein,Christian Meier et al.
Elena Tsourdi et al.
Hypoparathyroidism (HypoPT) is a rare endocrine disorder characterized by low parathyroid hormone (PTH) levels, hypocalcemia, hyperphosphatemia, reduced active vitamin D (1,25-OH2 vitamin D), and hypercalciuria. Due to its rarity, non-speci...
Clinical, Biochemical and Radiological Features of LRP5 Gene Variants in Children [0.03%]
儿童LRP5基因变异的临床、生化和影像学特征分析
Graziamaria Ubertini,Danilo Fintini,Francesco d&#x;Aniello et al.
Graziamaria Ubertini et al.
Alterations in the low-density lipoprotein receptor-related protein 5 (LRP5) gene have been associated with primary osteoporosis, leading to recurrent low-trauma fractures. Heterozygous carriers typically show a milder phenotype, with reduc...
Effectiveness of Radiotherapy in Preventing Heterotopic Ossification: A Meta-analysis of Randomized Controlled Trials Beyond Total Hip Arthroplasty [0.03%]
放射治疗预防异位骨化的疗效Meta分析（全髋关节置换以外的系统性疾病及创伤）
Lei Wen,Ge Chen,Changshun Chen et al.
Lei Wen et al.
Heterotopic ossification (HO) frequently occurs after procedures such as hip replacements, acetabular fractures, and elbow fractures. While radiotherapy (RT) has been a longstanding preventive measure against HO, its efficacy remains contro...
Effect of Oral Semaglutide on Volumetric BMD and Bone Microarchitecture in Overweight/Obese Individuals with Type 2 Diabetes [0.03%]
利拉鲁肽对超重或肥胖的2型糖尿病患者骨骼体积骨密度和骨微结构的影响
Liza Das,Sanjay Kumar Bhadada,Durairaj Arjunan et al.
Liza Das et al.
Obesity, type 2 diabetes, and therapeutic weight loss are all associated with impaired bone quantity and microarchitecture. Glucagon-like peptide receptor analogs (GLP1RAs) have direct beneficial effects on bone microarchitecture, in precli...
Expanding the Genotypic and Phenotypic Spectrum of P3H1 Related Osteogenesis Imperfecta [0.03%]
P3H1基因相关的成骨不全症的表型和基因型谱系的研究
Erdem Kındış,Enise Avcı Durmuşaliğlu,Elif Eviz
Erdem Kındış
Osteogenesis Imperfecta (OI) is a genetically heterogeneous disorder with a clinical spectrum ranging from mild to severe. Biallelic P3H1 (OMIM*610339) variants are generally associated with a severe recessive phenotype. This study reports ...
Impacts of Nonenzymatic Glycation Crosslinks in Bone Matrix on the Mechanosensitivity of Osteocyte [0.03%]
骨基质非酶糖化交联对骨细胞力学敏感性的影响
Cong-Jin Liu,Xiao Yang,Jing-Wen Shi et al.
Cong-Jin Liu et al.
The products of nonenzymatic glycation (NEG) are a key contributor to various types of osteoporosis, as they affect both the physical properties of bone matrix and the function of osteoblasts and osteoclasts. However, their impact on the me...
Yuehua Li,Lei Zheng,Wenjie Cheng et al.
Yuehua Li et al.
Heparan sulfate (HS) is synthesized in majority of cells in the human body and is typically released as an extension of polysaccharide chains, which then covalently bind to the protein core of proteoglycans to form heparan sulfate proteogly...