Transcriptomic responses to repeated exposure of human C3A liver spheroids to polystyrene nanoplastics [0.03%]
人C3A肝球体多次接触聚苯乙烯纳米塑料的转录组响应
Kyriaki Xiftou,Jian Jiang,Florian Caiment et al.
Kyriaki Xiftou et al.
Increasing evidence of nanoplastics (NPs) accumulation in the human liver has raised concerns regarding their potential hepatotoxicity. However, current knowledge is largely derived from animal studies or simplistic in vitro models, often w...
Revealing DNA damage levels in rat testicular germ cells in vivo using an adapted version of the alkaline comet assay [0.03%]
利用改良的碱性彗星实验法检测大鼠睾丸生精细胞中的DNA损伤水平
Ann-Karin Hardie Olsen,Xiaoxiong Ma,Congying Zheng et al.
Ann-Karin Hardie Olsen et al.
Heritable mutations in male germ cells pose a critical risk to human health and future generations, however standardized methods for assessing germ cell genotoxicity remain limited. We refined the in vivo alkaline comet assay (proof-of-conc...
Prenatal developmental toxicity of nitrous oxide: results of a GLP-compliant OECD TG 414 study in rats and implications for hazard classification [0.03%]
一氧化二氮的 prenatal development toxicity: ratosg 中进行的 GLP OECD TG 414 研究结果及其对危险分类的影响
Thomas Colnot,Wolfgang Dekant
Thomas Colnot
Nitrous oxide (N2O) is classified as a reproductive toxicant (Repr. 1B, H360D) under the EU CLP Regulation based on developmental toxicity findings in non-guideline rat studies conducted in the 1970s and 1980s. Those studies reported malfor...
The crucible of resilience: hormesis as the unifying principle of evolution, genetics, and epigenetics [0.03%]
应对逆境的熔炉：作为进化、遗传及表观遗传统合原理的环境强加的低剂量刺激反应关系（ hormesis）理论
Edward J Calabrese,Evgenios Agathokleous
Edward J Calabrese
The traditional linear no-threshold model of toxicity and stress fails to capture the complex, adaptive nature of biological systems. Hormesis-a biphasic dose-response phenomenon where low-dose stress induces beneficial, adaptive responses ...
Correction: From animal models to NAMs: a paradigm shift in developmental immunotoxicity testing [0.03%]
纠正：从动物模型到NAMs：发育免疫毒性检测的范式转变
Martina Iulini,Véronique de Bruijn,Selma Hurem et al.
Martina Iulini et al.
Published Erratum
Archives of toxicology. 2026 Jun 15. DOI:10.1007/s00204-026-04476-y 2026
Circadian regulation of hepatic detoxification: implications for drug-induced liver injury [0.03%]
肝脏解毒作用的昼夜节律调节及其对药物性肝损伤的影响
Ruiming Wen,Haixia Wang,Songtao Wang
Ruiming Wen
The hepatic capacity for xenobiotic detoxification exhibits pronounced circadian rhythmicity. The molecular basis of this rhythm lies in the autonomous transcriptional-translational feedback loops constituted by clock-controlled genes (CCGs...
Defining early carcinogenic markers for the prediction of the hazard potential of mineral fibres in an in vitro human 3D bronchial model [0.03%]
基于人体三维支气管模型的矿物纤维致癌潜力预测的早期癌变标志物研究
Vanessa Almonti,Serena Mirata,Mario Passalacqua et al.
Vanessa Almonti et al.
This study aimed to identify early carcinogenic markers to predict the hazard potential of mineral fibres using a human 3D bronchial model. Traditional 2D cell models inadequately mimic lung complexity, prompting the use of more physiologic...
Nanoplastic toxicity: an emerging blind spot in human risk assessment [0.03%]
纳米塑料毒理学：人类风险评估中的一个新兴盲点问题
Pragnesh Parmar,Gunvanti Rathod
Pragnesh Parmar
NLRP3 inflammasome activation by particles and fibers: implications for human hazard assessment [0.03%]
颗粒和纤维对NLRP3炎性小体的激活作用及其对人体危害评估的意义
Mathias Busch,Gerrit Bredeck,Hans Bouwmeester et al.
Mathias Busch et al.
The NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome has been shown to be involved in the manifestation of adverse effects following exposure to occupational, dietary and environmental particulate matter. In this review...
Recent advances in multidimensionally regulated nanozyme-integrated biosensors for rapid and ultrasensitive foodborne mycotoxin detection [0.03%]
近期基于多维度调控的纳米酶集成型生物传感器快速灵敏检测食品中霉菌毒素的研究进展
Chunlong Sun,Qiulin Wang,Zhengjie Chen et al.
Chunlong Sun et al.
Mycotoxins pose great risks to global food safety and human public health. Traditional instrumental detection suffers from high equipment costs and complicated procedures, whereas natural enzyme-based rapid assays are restricted by poor str...