Challenging the specificity of chlorzoxazone and 4-nitrophenol as marker substrates for CYP2E1 activity in Supersomes™ [0.03%]
氯唑沙宗和4-硝基酚作为CYP2E1活性标记底物在Supersomes中的特异性挑战研究
Anna Hellmann,Ann-Kathrin Lenich,Stephanie Ruez et al.
Anna Hellmann et al.
Cytochrome P450 2E1 (CYP2E1) plays a pivotal role in the metabolism and detoxification of low molecular-weight xenobiotics, as well as in their bioactivation into toxic and DNA-reactive intermediates. Prominent examples include drugs and ch...
Cell identity uncertainty and exposure heterogeneity in germ cell-resolved comet assays [0.03%]
基于生精细胞的彗星实验中的细胞身份不确定性与暴露异质性
Man Sun,Dan Zang,Jun Chen
Man Sun
How structural variations in synthetic cannabinoids affect their metabolism: A pilot study on the in vivo metabolism of 8 synthetic cannabinoid receptor agonists [0.03%]
合成大麻素结构变异对其代谢影响的初步研究：8种合成大麻素受体激动剂的体内代谢研究
María Mata-Pesquera,David Fabregat-Safont,Manuela Barneo-Muñoz et al.
María Mata-Pesquera et al.
The structural diversity and continuous emergence of synthetic cannabinoid receptor agonists (SCRAs) pose an important challenge to forensic and clinical toxicology. Understanding their metabolic pathways is essential for identifying reliab...
No clear evidence of PFAS-induced immunomodulation in SARS-CoV-2-specific human T cell responses following vaccination [0.03%]
全人源T细胞小鼠模型中PFAS对新冠疫苗诱导的免疫反应无影响
Hermann-Josef Thierse,Katharina Sommerkorn,Moustapha Sy et al.
Hermann-Josef Thierse et al.
The aryl hydrocarbon receptor is downregulated in MASLD while its activation attenuates steatosis in human hepatocytes through an IGFBP1-associated pathway [0.03%]
aryl烃受体在MASLD中表达下调，而其激活通过与IGFBP1相关的途径减轻人肝细胞脂变
Marta Del Pozo-Medina,Polina Soluyanova,Eugenia Pareja et al.
Marta Del Pozo-Medina et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) represents a growing global health concern; however, its multiple pathogenic mechanisms remain incompletely understood. The role of the aryl hydrocarbon receptor (AHR) in MASL...
Learning the assay, not the hazard: how computational toxicity models inherit the artifacts of their high-throughput training data [0.03%]
学习测试方法，而非毒性危害：计算毒理学模型如何继承其高通量训练数据中的伪像
Muhammad Javid Iqbal,Tooba Amjad,Cristian Paz
Muhammad Javid Iqbal
High-throughput screening data have become the de facto ground truth for in silico toxicology. But a high-throughput "active" can reflect target engagement, non-specific cytotoxicity, or assay interference and the programmes that generate t...
Does fluoridated toothpaste induce genotoxicity and cytotoxicity in human oral epithelial cells? [0.03%]
含氟牙膏诱导人口腔上皮细胞遗传毒性和细胞毒性吗？
Gabriel Carvalhal de Aguiar,Antonio Silva,Daniel Araki Ribeiro
Gabriel Carvalhal de Aguiar
Revisiting cannabinoid receptor-2: a key regulator of hepatic steatosis, inflammatory cascades, and fibrotic progression [0.03%]
大麻素受体-2再探：肝脏脂变、炎症级联和纤维化进展的关键调节因子
Shilpa Kumari,Biswanath Nayak,Preeti Garg et al.
Shilpa Kumari et al.
Liver diseases constitute a major global health challenge, affecting over 25% of the world's population, with metabolic dysfunction-associated steatotic liver disease (MASLD) emerging as the most prevalent chronic liver disorder and a leadi...
Molecular characterization of the uterotrophic assay: temporal gene expression changes in uterus and pituitary gland following ethinylestradiol [0.03%]
雌酚酮诱发的大鼠子宫和垂体基因表达的改变及其与子宫致增生活性评价的关系研究
M Pavkovic,A Mahringer,U Bach et al.
M Pavkovic et al.
The uterotrophic bioassay is a recognized tool for assessing estrogenic activities of chemicals, relying on estrogen-induced uterine growth. This study employed the assay in immature female rats using ethinyl estradiol (EE) to explore tempo...
Chalcones as multitarget modulators in non-small cell lung cancer: mechanistic insights and therapeutic perspectives [0.03%]
茋类化合物作为非小细胞肺癌多靶标调节剂的机制及治疗意义研究
Ellen Mayara Souza Cruz,Virginia Márcia Concato-Lopes,Mariana Barbosa Detoni et al.
Ellen Mayara Souza Cruz et al.
Non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related mortality worldwide, and the search for novel therapeutic strategies is ongoing. Chalcones, a class of naturally occurring and synthetically derived open-chain f...