Mechanistic investigation of the hepatotoxicity and potential carcinogenicity of microcystin-LR, -LA, and -RR in the HepaRG cell line model [0.03%]
微囊藻毒素-LR、-LA和-RR肝毒性和潜在致癌性的机制研究：肝细胞系模型中的研究
Enzo Zini Moreira Silva,Sahra Kiessig,Ilinca Suciu et al.
Enzo Zini Moreira Silva et al.
Microcystins (MCs) are cyanobacterial toxins found in water and food and are suspected to pose significant health risks, particularly to the liver. To gain insight into the mechanisms of hepatotoxicity and the potential carcinogenicity of M...
Multi-omics study to elucidate molecular mechanism of polyhexamethylene guanidine phosphate (PHMG-p)-induced pulmonary damage in mice [0.03%]
用于阐明聚六亚甲基胍磷酸盐（PHMG-P）诱导小鼠肺损伤的分子机制的多组学研究
Jung Dae Lee,Hyang Yeon Kim,Jueng-Eun Im et al.
Jung Dae Lee et al.
Polyhexamethylene guanidine phosphate (PHMG-p), a cationic disinfectant previously used in humidifiers, has been linked to severe pulmonary diseases in Korea. This study aimed to elucidate the molecular mechanisms underlying PHMG-p-induced ...
Aging in a highly polluted world: challenges and solutions to prevent Alzheimer's disease [0.03%]
污染严重的世界中的老龄化：预防阿尔茨海默病的挑战与解决方案
Jose L Domingo
Jose L Domingo
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder globally and a leading cause of disability and death among the elderly. As populations age worldwide, the epidemiological burden of AD is expected to more than double...
Diazinon-induced oxidative stress and organ toxicity in rodent models: a narrative review of mechanistic pathways, biomarkers and antioxidant interventions [0.03%]
二硫磷诱导的啮齿动物模型氧化应激和器官毒性：机制路径、生物标志物及抗氧化干预的叙述性回顾
Ruxi Liu,Bo Wu
Ruxi Liu
Diazinon (DZN) is a widely used organophosphorus insecticide whose toxicity has traditionally been attributed to acetylcholinesterase inhibition after metabolic activation to diazoxon. However, a growing body of rodent evidence indicates th...
Will there ever be an in vitro assay that is predictive for human hepatotoxicity? [0.03%]
体外试验能预测人类肝毒性吗？
David C Thompson
David C Thompson
Advances in novel alternative methods (NAMs)-including in silico modeling, hepatic co-cultures, 3D models such as spheroids and organoids, and microphysiological liver platforms-have greatly improved our ability to study human hepatic biolo...
Electronic cigarette aerosols disrupt airway barrier function via MMP-dependent E-cadherin cleavage: findings from cell culture and murine models [0.03%]
电子烟气溶胶通过基质金属蛋白酶依赖性的E-钙黏着蛋白切割破坏呼吸道屏障功能：体外和整体动物模型的研究结果
Amelia L Beaumont,Sarah G Ozeki,Claire E Lee et al.
Amelia L Beaumont et al.
Electronic cigarette (e-cigarette) use continues to rise, yet the toxicological mechanisms by which inhaled aerosols impair airway epithelial integrity remain poorly defined. E-cadherin, a key adherens junction protein required for epitheli...
Mitochondrial dynamics in environmental neurotoxicity: beyond oxidative stress toward spatial and functional reorganization [0.03%]
环境神经毒性下的线粒体动态变化：从氧化应激到空间和功能重组
Xinyi Yu,Weiqi Lin,Wenqi Hu et al.
Xinyi Yu et al.
Environmental stressors are widely recognized as key drivers of neurotoxicity, yet their underlying mechanisms are still predominantly interpreted within a damage-centered framework focused on mitochondrial dysfunction, particularly oxidati...
The in vitro alkaline comet assay with liver models as a complementary tool for genotoxicity assessment of N-nitrosamines [0.03%]
体外碱性彗星试验与肝模型结合用于亚硝胺致突变性评估的辅助方法
M A Djuari,A Londenberg,A Bassan et al.
M A Djuari et al.
N-nitrosamine (NA) impurities in pharmaceuticals represent "cohort of concern" compounds under ICH M7(R2), due to their mutagenic/carcinogenic potential, involving cytochrome P450 (CYP)-mediated metabolic activation. Increasing interest in ...
PPAOT predictor: ARKA-RASTR strategy-driven rodent acute oral toxicity prediction for pyrazole and pyrrolidine scaffolds-based chemicals with intelligent mechanistic interpretation [0.03%]
基于吡唑和吡咯啶骨架化合物的智能机理解释的急性口服毒性预测模型：ARKA-RASTR策略驱动的PPAOT预测器
Jianing Xu,Shuo Chen,Ting Ren et al.
Jianing Xu et al.
Pyrazole and pyrrolidine represent two classes of high-frequency nitrogen-containing "privileged scaffolds" in drug discovery and industrial chemicals; however, their potential acute toxicity poses significant challenges to clinical transla...
Associations of serum per- and polyfluoroalkyl substances (PFAS) mixture with the risk of chronic diseases: evidence from single‑ , multi-pollutant, and machine learning models [0.03%]
血清含氟化合物混合物与慢性病风险的关系：来自单污染物、多污染物和机器学习模型的证据
Mei Li,Liting Sheng,Zige Ding et al.
Mei Li et al.
Per- and polyfluoroalkyl substances (PFAS) are persistent chemicals commonly found in consumer products. Despite growing concern over their health effects, their associations with chronic diseases in humans are still unclear. We included 10...