Reassessing the carcinogenic potential of dibutyl hydrogen phosphate: new insight from repeated-dose toxicity studies [0.03%]
二丁基氢磷酸酯致癌性的潜在性重新评估：重复剂量毒性研究的新见解
Susann Fayyaz,Ursula G Sauer,Qiang Li et al.
Susann Fayyaz et al.
ADME profile of phencyclidine (PCP) analogues: emerging dissociative hallucinogens 3-MeO-PCP (CAS: 72242-03-6) and 4-MeO-PCP (CAS: 2201-35-6)-a multi-in silico approach for comprehensive prediction of absorption, distribution, metabolism and excretion relevant to clinical and forensic toxicology [0.03%]
苯环己哌啶（PCP）类似物的药代动力学性质：新型分离式迷幻药物3-MeO-PCP和4-MeO-PCP的吸收、分布、代谢与排泄预测
Kamil Jurowski,Damian Kobylarz,Maciej Noga
Kamil Jurowski
A multi-platform in silico workflow was applied to characterize the ADME profile of the methoxy-substituted phencyclidines 3-MeO-PCP and 4-MeO-PCP for clinical toxicological and forensic use. Predictions from ACD/Percepta, SwissADME, pkCSM,...
Assessment of endocrine disruptor impact on carbohydrate metabolism in the HepaRG human hepatic cell line [0.03%]
内分泌干扰物对HepaRG人肝细胞系糖代谢影响的评估
Kévin Bernal,Arnaud Tête,Béatrice Le-Grand et al.
Kévin Bernal et al.
Endocrine-disrupting chemicals (EDCs) are increasingly implicated in the development of metabolic disorders such as type 2 diabetes mellitus (T2DM). As hepatic dysfunction is a hallmark of early metabolic disease, we investigated how EDCs m...
Comparative toxicity of plant protection products, their active substances and mixtures in zebrafish embryos and HepaRG cells [0.03%]
用于植物保护产品的植物保护产品、其活性物质和混合物的斑马鱼胚胎和HepaRG细胞中的比较毒性
Bente Nissen,Alkiviadis Stagkos-Georgiadis,Martin Krauss et al.
Bente Nissen et al.
The intensive use of plant protection products (PPPs) is essential in modern agriculture to ensure food security. PPPs are complex formulations of active substances (ASs) and co-formulants, yet regulatory risk assessment primarily focuses o...
Metabolic and antioxidant imbalance in Sertoli cells induced by tributyltin exposure is accompanied by Sirt3 downregulation [0.03%]
三丁基锡暴露诱导的大鼠支持细胞线粒体代谢及抗氧化失衡与Sirt3下调有关
L Rato,A Bastos,L Machado et al.
L Rato et al.
Tributyltin (TBT), an environmental obesogen and endocrine disruptor that can accumulate in the food chain, impairs Sertoli cell (SC) function, yet its impact on the redox-regulating SIRT1/PGC-1α/SIRT3 axis remains uncharacterized. This st...
Applicability of in vitro mouse lung epithelial cell responses for potency grouping and hazard identification of metal oxide nanoparticles: impact of form, size, surface area, and solubility on toxicity [0.03%]
体外小鼠肺上皮细胞对金属氧化物纳米颗粒的效力分组和危害识别的适用性：形态、尺寸、比表面积和溶解度对毒性的影响
Andrey Boyadzhiev,Andrew Williams,Sabina Halappanavar
Andrey Boyadzhiev
Human health risk assessment of engineered nanomaterials (ENM; materials with any dimension or structure between 1 and 100 nm) is challenged by the large number of compounds requiring assessment and the intricate association between physico...
Identification of functional genetic components modulating toxicity response to PFOS using genome-wide CRISPR screens in HepG2/C3A cells [0.03%]
利用基于CRISPR的基因敲除筛选鉴定全基因组范围内调节PFOS毒性的功能遗传成分
Chanhee Kim,Abderrahmane Tagmount,Zhaohan Zhu et al.
Chanhee Kim et al.
Perfluorooctane sulfonate (PFOS) poses significant health and environmental risks due to its persistence and widespread use and has been linked to various adverse outcomes, such as liver toxicity. Although the molecular responses and toxici...
Classification of industrial chemicals for respiratory chemosensory irritation using the TRPV1-expressing neuronal SH-SY5Y cell model and machine learning [0.03%]
基于瞬时受体电位香草素1表达神经细胞模型和机器学习的呼吸用化学物气道刺激分类研究
María Hinojosa,Gunnar Johanson,Ulf Norinder et al.
María Hinojosa et al.
Immune effects of trichloroethylene: key findings of occupational hypersensitivity syndrome and its pathogenesis [0.03%]
三氯乙烯的免疫效应：职业性过敏综合征及其发病机制的主要发现
Tamie Nakajima,Yuki Ito,Hisao Naito et al.
Tamie Nakajima et al.
Trichloroethylene (TCE) remains a versatile organic solvent used globally. In recent years, immunological occupational diseases such as hypersensitivity syndrome (HS) and systemic sclerosis (SSc) have attracted attention in terms of the num...
Sex-specific toxicity targets of aristolochic acids: nephrotoxicity in males, hepatotoxicity in females [0.03%]
马兜铃酸类化合物的性别特异性毒性靶标：对男性主要造成肾毒性，对女性主要造成肝毒性
Hong-Ching Kwok,Nikola M Pavlović,Zongwei Cai et al.
Hong-Ching Kwok et al.
Aristolochic acids (AAs), derived from Aristolochia herbs, are well-known nephrotoxins, and emerging evidence suggests their potential role in the development of liver cancers. However, the specific organs most affected by AAs, particularly...