Gasdermin D membrane pores orchestrate IL-1α secretion from necrotic macrophages after NFS-rich silica exposure [0.03%]
富氮硅石暴露后气真皮素D膜孔调节坏死巨噬细胞中IL-1α的释放
Riccardo Leinardi,Amandine Pochet,Francine Uwambayinema et al.
Riccardo Leinardi et al.
IL-1α is an intracellular danger signal (DAMP) released by macrophages contributing to the development of silica-induced lung inflammation. The exact molecular mechanism orchestrating IL-1α extracellular release from particle-exposed macr...
Toxicology of 3-monochloropropane-1,2-diol and its esters: a narrative review [0.03%]
3-氯-1,2-丙二醇及其酯的毒理学：叙述性综述
Elena Fattore,Alessia Lanno,Alberto Danieli et al.
Elena Fattore et al.
3-Monochloropropane-1,2-diol (3-MCPD) is a chiral molecule naturally existing as a racemic mixture of (R)- and (S)-enantiomers. It was thoroughly investigated during the 1970s as a male antifertility drug until research was abandoned becaus...
Lysosomal dysfunction in Schwann cells is involved in bortezomib-induced peripheral neurotoxicity [0.03%]
自噬功能障碍参与硼替佐米诱导的外周神经毒性作用
Zhanxun Wu,Wenping Yan,Ke Wang et al.
Zhanxun Wu et al.
Bortezomib (BTZ) is a proteasome inhibitor serves as a first-line drug for multiple myeloma treatment. BTZ-induced peripheral neuropathy (BIPN) is the most common adverse effect of BTZ with an incidence as high as 40-60%. However, the patho...
Metabolic signature of HepaRG cells exposed to ethanol and tumor necrosis factor alpha to study alcoholic steatohepatitis by LC-MS-based untargeted metabolomics [0.03%]
基于LC-MS的无靶标代谢组学研究乙醇和肿瘤坏死因子α暴露诱导的HepaRG细胞酒精性脂肪肝病模型的代谢标志物
Elias Iturrospe,Rani Robeyns,Katyeny Manuela da Silva et al.
Elias Iturrospe et al.
Despite the high prevalence of alcoholic liver disease, its identification and characterization remain poor, especially in early stages such as alcoholic fatty liver disease and alcoholic steatohepatitis. This latter implies diagnostic diff...
Morphological alterations in C57BL/6 mouse intestinal organoids as a tool for predicting chemical-induced toxicity [0.03%]
C57BL/6小鼠肠类器官形态变化可作为化学诱导毒性预测的工具
Ziwei Wang,Shen Chen,Yaqin Pang et al.
Ziwei Wang et al.
Intestinal organoid may serve as an alternative model for toxicity testing. However, the linkage between specific morphological alterations in organoids and chemical-induced toxicity has yet to be defined. Here, we generated C57BL/6 mouse i...
SIRT3/GLUT4 signaling activation by metformin protect against cisplatin-induced ototoxicity in vitro [0.03%]
二甲双胍通过激活SIRT3 / GLUT4信号转导来对抗顺铂引起的耳毒性作用（体外研究）
Peiyu Du,Tianyi Liu,Pan Luo et al.
Peiyu Du et al.
Cisplatin is highly effective for killing tumor cells. However, as one of its side effects, ototoxicity limits the clinical application of cisplatin. The mechanisms of cisplatin-induced ototoxicity have not been fully clarified yet. SIRT3 i...
Mammalian toxicity of trifluoroacetate and assessment of human health risks due to environmental exposures [0.03%]
全氟丙基乙烯基醚的哺乳动物毒性和环境暴露对人类健康的风险评估——以血清素转运体为例
Wolfgang Dekant,Raphael Dekant
Wolfgang Dekant
While trifluoroacetic acid has limited technical uses, the highly water-soluble trifluoroacetate (TFA) is reported to be present in water bodies at low concentrations. Most of the TFA in the environment is discussed to arise from natural pr...
Species differences and human relevance of the toxicity of 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitors and a new approach method in vitro for investigation [0.03%]
4-羟基苯丙酮酸双氧化酶（HPPD）抑制剂毒性物种差异及对人体的相关性研究及其新体外研究方法探索
Jane Botham,Richard W Lewis,Kim Z Travis et al.
Jane Botham et al.
The mode of action (MoA) of the 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor herbicides in mammals is well described and is generally accepted to be due to a build-up of excess systemic tyrosine which is associated with the range of...
Evidential requirements for the regulatory hazard and risk assessment of respiratory sensitisers: methyl methacrylate as an example [0.03%]
以甲基丙烯酸甲酯为例的呼吸致敏剂监管危害和风险评估所需证据要求
Bette Meek,James W Bridges,Andrew Fasey et al.
Bette Meek et al.
This review addresses the need for a framework to increase the consistency, objectivity and transparency in the regulatory assessment of respiratory sensitisers and associated uncertainties. Principal issues are considered and illustrated t...
Circulating microRNAs as promising testicular translatable safety biomarkers: current state and future perspectives [0.03%]
循环microRNA有望成为可翻译的安全生物标志物以用于评估睾丸毒性：现状与未来展望
Jiangwei Zhang,Sarah Campion,Natasha Catlin et al.
Jiangwei Zhang et al.
Drug-induced testicular injury (DITI) is one of the often-observed and challenging safety issues seen during drug development. Semen analysis and circulating hormones currently utilized have significant gaps in their ability to detect testi...