Neuropathological measures of increased tau phosphorylation across the Down syndrome lifespan [0.03%]
唐氏综合症生命周期中tau过度磷酸化的神经病理学指标
Jesse R Pascual,Isabel Rivera,Halyma Nguyen et al.
Jesse R Pascual et al.
Individuals with Down syndrome (DS) have an increased risk of developing Alzheimer disease (AD), with nearly all individuals exhibiting AD neuropathology, including amyloid beta (Aβ) plaques and neurofibrillary tangles (NFT), by age 40 yea...
A distinct tau oligomer strain defines the molecular and proteomic landscape of rapidly progressive Alzheimer's disease [0.03%]
一种独特的tau寡聚体应激定义了快速进展型阿尔茨海默病的分子和蛋白质组景观
Tayyaba Saleem,Wiebke Möbius,Matthias Schmitz et al.
Tayyaba Saleem et al.
Rapidly progressive Alzheimer's disease (rpAD) is a rare subtype with rapid decline, but its molecular underpinnings remain poorly defined. Here, brain-derived tau oligomers (TauO) were systematically compared across nondemented controls, s...
TDP-43 impairs glycolysis by sequestering hexokinase 1 in amyotrophic lateral sclerosis [0.03%]
TDP-43通过在肌萎缩侧索硬化中捕获己糖激酶1来损害糖酵解
Cassandra Barone,Rihua Wang,Sarah Cooke et al.
Cassandra Barone et al.
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive motor neuron degeneration and cytoplasmic mislocalization of TDP-43. While metabolic dysfunction is increasingly recognized in ALS, the m...
Editorial Expression of Concern: Neurofibrillary and neurodegenerative pathology in APP-transgenic mice injected with AAV2-mutant TAU: neuroprotective effects of Cerebrolysin [0.03%]
表达关注声明：APP转基因小鼠注射AAV2突变tau后的神经原纤维和神经营养不良病理变化：脑活素的神经保护作用
Kiren Ubhi,Edward Rockenstein,Edith Doppler et al.
Kiren Ubhi et al.
H3K27ME3 loss in diffuse midline gliomas lacking H3K27M or EZHIP expressions, a potential diagnostic pitfall! [0.03%]
缺乏H3K27M或EZHIP表达的弥漫内皮中间瘤中出现H3K27ME3丢失，可能成为潜在的诊断陷阱！
Arnault Tauziède-Espariat,David Castel,Yassine Ajlil et al.
Arnault Tauziède-Espariat et al.
Association of mitochondrial genetic background with pS65-Ub in Lewy body disease [0.03%]
线粒体遗传背景与路易小体重塑素pS65-Ub关联性研究
Ngan Le Kim Tran,Xu Hou,Michael G Heckman et al.
Ngan Le Kim Tran et al.
Mitochondrial dysfunction is a hallmark of neurodegenerative diseases, where respiratory defects and downstream bioenergetic failures arise from impaired mitophagy or the accumulation of damaged mitochondria. Mitophagy is a mitochondrial qu...
Pediatric H3 G34-mutant diffuse hemispheric glioma: clinical, imaging and molecular prognostic factors, MGMT expression, and temozolomide response [0.03%]
儿科H3 G34突变半球胶质瘤的临床、影像及分子预后因素，MGMT表达和替莫唑胺反应
Dana Tlais,Qunyu Zhang,Jordan T Roach et al.
Dana Tlais et al.
Previous studies have demonstrated poor outcomes in pediatric patients with H3 G34-mutant diffuse hemispheric glioma (DHG). However, the biological basis for this therapeutic resistance remains poorly understood. Furthermore, the effectiven...
Multicenter Study
Acta neuropathologica. 2026 Mar 2;151(1):22. DOI:10.1007/s00401-026-02992-w 2026
Disentangling on and off-target binding in flortaucipir PET: a voxel-to-voxel P-tau, ferric iron, and MAO-B histology-to-flortaucipir PET comparison [0.03%]
一种和非特异性结合的氟环桃西必尔正电子发射断层扫描成像：基于tau蛋白磷酸化、三价铁和单胺氧化酶B的组织学与氟环桃西必尔正电子发射断层扫描成像的像素对比研究
Yuheng Chen,Renaud La Joie,Felipe L Pereira et al.
Yuheng Chen et al.
Flortaucipir PET imaging has significantly advanced our ability to visualize tau pathology in vivo. However, off-target Flortaucipir signal remains a considerable challenge for interpreting of imaging results, particularly in non-Alzheimer'...
Comparative Study
Acta neuropathologica. 2026 Feb 25;151(1):21. DOI:10.1007/s00401-026-02983-x 2026
Epigenomic subtypes of late-onset Alzheimer's disease reveal distinct microglial signatures [0.03%]
表观基因型亚型的晚发性阿尔茨海默病呈现明显的小胶质细胞特征
Valentin T Laroche,Rachel Cavill,Morteza Kouhsar et al.
Valentin T Laroche et al.
Growing evidence suggests that clinical, pathological, and genetic heterogeneity in late-onset Alzheimer's disease (LOAD) contributes to variable therapeutic outcomes, potentially explaining many trial failures. Advances in molecular subtyp...
Correction: Selective targeting of 3 repeat Tau with brain penetrating single chain antibodies for the treatment of neurodegenerative disorders [0.03%]
纠正：选择性靶向3重复Tau蛋白的穿透血脑屏障的单链抗体治疗神经退行性疾病
Brian Spencer,Sven Brüschweiler,Marco Sealey-Cardona et al.
Brian Spencer et al.
Published Erratum
Acta neuropathologica. 2026 Feb 19;151(1):18. DOI:10.1007/s00401-026-02982-y 2026