AETA peptide contributes to Alzheimer's disease signature of synapse dysfunction [0.03%]
AETA肽贡献于阿尔茨海默病的突触功能障碍特征
Jade Dunot,Carine Gandin,Marin Truchi et al.
Jade Dunot et al.
Alzheimer's disease (AD), the leading cause of dementia, is characterized by early synaptic dysfunction that precedes overt cognitive decline. While amyloid-β and Tau remain central to AD pathogenesis, molecular triggers of synapse weakeni...
GRP78 associates with alpha-synuclein in vulnerable neurons of the Parkinson's disease brain [0.03%]
格兰氏蛋白78与帕金森病易感神经细胞中的α-突触核蛋白相互作用
Dominik Hrabos,Anna Mrowiecova,Jitka Cicmancova et al.
Dominik Hrabos et al.
Reevaluating the role of beta2-microglobulin: new insights on selective vulnerability in ALS pathology [0.03%]
β2微球蛋白在ALS病理选择性易感性中的作用及其新见解
Melanie Leboeuf,Jik Nijssen,Laura Helen Comley et al.
Melanie Leboeuf et al.
Amyotrophic lateral sclerosis (ALS) is characterized by the selective loss of motor neurons (MNs). Why these neurons are particularly vulnerable in ALS remains unclear, as does why certain MN groups remain resistant throughout the disease c...
TANC1::HTRA1 and KPNA4::WWTR1 fusions in non-vestibular intracranial schwannomas [0.03%]
非前庭颅内施万瘤中的TANC1::HTRA1和KPNA4::WWTR1融合基因
Takahiro Tsuchiya,Satoru Miyawaki,Yudai Hirano et al.
Takahiro Tsuchiya et al.
Neocortical tau burden determines the degree of cognitive impairment in individuals with Braak stage V neurofibrillary degeneration [0.03%]
新皮层tau负荷决定Braak五期神经原纤维缠结变性个体认知障碍的程度
Timothy E Richardson,Jonathan Cherry,Shrishtee Kandoi et al.
Timothy E Richardson et al.
Alzheimer disease neuropathologic change (ADNC) is considered to be the most common cause of cognitive decline and dementia worldwide. ADNC level is determined using the density of neuritic plaques in combination with the topographical dist...
Alpana Singh,Marisa N Denkinger,Antoine Leuzy et al.
Alpana Singh et al.
Cerebral amyloid angiopathy (CAA) is a cerebrovascular disorder characterized by the deposition of amyloid-β (Aβ) in the walls of leptomeningeal and cortical blood vessels that increases risk of intracerebral hemorrhages and progressive c...
The phosphoproteomic landscape of the neurological manifestations in tuberous sclerosis complex [0.03%]
结节性硬化症神经表现的磷酸化蛋白质组景观
Marie Girodengo,Simeon R Mihaylov,Katarzyna Klonowska et al.
Marie Girodengo et al.
Tuberous sclerosis complex (TSC) is a rare disease caused by mutations in TSC1 and TSC2, resulting in activation of mechanistic target of rapamycin complex 1 (mTORC1). Neurological manifestations in TSC patients include epilepsy, autism and...
Future directions in the treatment of brain metastases: evaluating the role of cellular players in the tumour microenvironment [0.03%]
脑转移治疗的未来方向：评估肿瘤微环境中细胞的作用
Chris W Govaerts,J Marc C van Dijk,Anouk van der Hoorn et al.
Chris W Govaerts et al.
Recent clinical trials have demonstrated the efficacy of different modalities of systemic therapy in treating brain metastases, including immune checkpoint inhibitors and various types of targeted therapy. These findings expand treatment op...
Frequency of mixed neuropathologies in individuals with down syndrome with and without Alzheimer's dementia [0.03%]
唐氏综合征伴或不伴有阿尔茨海默病痴呆的混合神经病理特征频率
Lisi Flores-Aguilar,Thomas D Zaikos,Isabel Rivera et al.
Lisi Flores-Aguilar et al.
Individuals with Down syndrome (DS) develop Alzheimer's disease neuropathological change (ADNC) by the age of 40 years, and most develop dementia by their early 50s. The frequency of co-pathologies in clinically and neuropathologically char...
APOE ε4 influences the widespread TDP-43 pathological subtype in sporadic amyotrophic lateral sclerosis [0.03%]
APOE ε4影响散发性肌萎缩侧索硬化中广泛存在的TDP-43病理亚型
Yuya Hatano,Asa Nakahara,Mari Tada et al.
Yuya Hatano et al.
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder, most sporadic cases exhibiting TAR DNA-binding protein 43 (TDP-43) pathology. The anatomical distribution of TDP-43 pathology varies among patients; however, factors...