Prion-like transmission and propagation of human β-amyloid to the bank vole rodent model [0.03%]
人β淀粉样蛋白在广尾松鼠鼠模型中的朊病毒样的传播和扩散
Michele Angelo Di Bari,Rosalia Bruno,Geraldina Riccardi et al.
Michele Angelo Di Bari et al.
Over the past decades, growing experimental and observational evidence has suggested that Aβ and pTau, the hallmarks of Alzheimer's disease (AD), may spread through the nervous system via a prion-like mechanism. Here, we investigated the t...
Inhibition of tRNA fragments dysregulated in human mTLE exacerbates pathology and seizure activity [0.03%]
抑制人类mTLE中失调的tRNA片段可加重病理和癫痫发作活动
Noora Puhakka,Vamshidhar R Vangoor,Andreia Gomes-Duarte et al.
Noora Puhakka et al.
Mesial temporal lobe epilepsy (mTLE) is a subtype of focal epilepsy in which approximately one-third of patients develop pharmaco-resistance, likely driven by multiple mechanisms including structural changes and dysregulated non-coding RNAs...
VMA21 deficiency leads to autophagic dysregulation and altered vesicle trafficking in X-linked myopathy with excessive autophagy [0.03%]
VMA21缺陷通过自噬失调和囊泡转运改变引起X-连锁自噬过度型肌病
Christian A Suarez,Sara K Pittman,Michio Inoue et al.
Christian A Suarez et al.
X-Linked myopathy with excessive autophagy (XMEA) is a rare vacuolar myopathy caused by mutations in Vma21, an assembly chaperone required for vacuolar H⁺-ATPase (V-ATPase) function. However, the mechanisms linking Vma21 deficiency to prog...
Donor-specific pathological features associate with genetic background, lesion type distribution, and clinical heterogeneity in multiple sclerosis [0.03%]
与遗传背景、病变类型分布及临床异质性相关的供者特异性病理特征在多发性硬化症中的关联研究
Lukas Lütje,J Q Alida Chen,Jörg Hamann et al.
Lukas Lütje et al.
Multiple sclerosis (MS) shows pronounced pathological and clinical variability between individuals, reflecting differences in genetic susceptibility, inflammatory activity, and tissue repair. This variability complicates efforts to relate l...
Tau368 improves p-tau diagnostic accuracy for FTLD-tau from FTLD-TDP [0.03%]
tau368改善了FTLD-tau与FTLD-TDP的p-tau诊断准确性
Przemysław R Kac,Katheryn A Q Cousins,Alicja Szadziewska et al.
Przemysław R Kac et al.
Across tauopathies-Alzheimer's disease (AD), frontotemporal lobar degeneration due to tau (FTLD-tau)-we compared cerebrospinal fluid (CSF) biomarkers of phosphorylated-tau (p-tau) p-tau181, p-tau212, tau368, total tau (t-tau), and the tau36...
Risk stratification for meningiomas with discordant molecular classification [0.03%]
分子分类不一致的脑膜瘤的风险分层
Brooke C Braman,Ayush Aggarwal,Minh P Nguyen et al.
Brooke C Braman et al.
CTE has multiple pathologic variants that might relate to different clinical symptom presentation [0.03%]
CTE具有多种病理亚型，可能与不同的临床表现相关
Fatima Tuz-Zahra,Eli Hallowell,Chris Tilton et al.
Fatima Tuz-Zahra et al.
Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disease found in individuals with a history of repetitive head injury (RHI) received through playing contact sports. Currently, CTE can only be diagnosed after death ...
Neuropathological study of the effects of aducanumab anti-Aβ immunotherapy on patients with Alzheimer's disease [0.03%]
关于抗Aβ免疫疗法阿杜卡努单抗对阿尔茨海默病患者神经病理影响的研究
Lindsay A Welikovitch,Derek H Oakley,Rachel E Bennett et al.
Lindsay A Welikovitch et al.
Fluid and imaging biomarker data show that anti-amyloid (Aβ) antibodies promote the clearance of Aβ from the brains of patients with Alzheimer's disease (AD). We examined postmortem brain tissue of individuals who participated in aducanum...
Mechanisms of increased Alzheimer's disease pathology with R47H and R62H TREM2 variants [0.03%]
R47H和R62H TREM2变异体增加阿尔茨海默病病理变化的机制
Nurun N Fancy,Nanet Willumsen,Vicky M N Chau et al.
Nurun N Fancy et al.
TREM2 plays multiple functional roles in microglia and variants are associated with increased risks of Alzheimer's disease (AD). Genetic polymorphisms reducing expression of the functionally related protein CD33 are protective. Here we have...
Expression of GPR34 in microglia remains stable in human Alzheimer's disease [0.03%]
人阿尔茨海默病中微胶质细胞中的GPR34表达稳定
Sophie Seiffer,Jonas Rotter,Jana Brendler et al.
Sophie Seiffer et al.
Microglia are the resident immune cells of the human central nervous system and play key roles in development, homeostasis, and disease. These functions are mediated by a broad repertoire of cell-surface receptors, including G protein-coupl...