Targeting chordoma via an isocitrate dehydrogenase-1-dependent susceptibility to redox metabolism [0.03%]
靶向胶质瘤的异柠檬酸脱氢酶依赖性抗氧化代谢弱点
Matthew Pun,Akash Deogharkar,Siva Kumar Natarajan et al.
Matthew Pun et al.
Chordomas are rare cancers that arise along the axial skeleton. Alterations in metabolism are a hallmark of cancer, and we sought to identify metabolic vulnerabilities in chordoma. We discovered that the tricarboxylic acid (TCA)-related enz...
Validation of proposed cIMPACT-NOW update 12 molecular grading criteria for IDH-mutant astrocytoma [0.03%]
IDH突变型星形细胞瘤拟议的cIMPACT-NOW更新12条分子分级标准的验证研究
Timothy E Richardson,Jorge Samanamud,Michael Christian Virata et al.
Timothy E Richardson et al.
Cerebral amyloid angiopathy, brain iron concentrations, and cognitive decline in older people [0.03%]
老年痴呆患者脑淀粉样血管病、铁浓度与认知功能下降的关系
Sonal Agrawal,Maude Wagner,Sue E Leurgans et al.
Sonal Agrawal et al.
Cerebral amyloid angiopathy (CAA) is a common brain pathology in older people and has been recently recognized as a major risk factor for amyloid-related imaging abnormalities during anti-amyloid antibody therapy. CAA pathophysiology may in...
Hina Khan,Mary Gifford,Arash Kordbacheh et al.
Hina Khan et al.
Parkinson's disease (PD) is characterized by progressive degeneration of nigrostriatal dopamine neurons and synucleinopathy, which is the accumulation of aggregated α-synuclein (α-syn). Increasing evidence implicates α-syn-associated neu...
Correlative ultrastructural mapping of Lewy pathology reveals regional diversity in Parkinson's and dementia with Lewy bodies [0.03%]
相关超微结构莱维病理图谱的绘制揭示了帕金森病和路易体痴呆在不同脑区的多样性
Notash Shafiei,Daria Proniakova,Marija Simjanoska et al.
Notash Shafiei et al.
Lewy body diseases, including Parkinson's disease (PD) and dementia with Lewy bodies (DLB), are defined by neuronal accumulation of misfolded α-synuclein (α-Syn), yet the ultrastructural diversity of these inclusions across brain regions ...
Chao Qi,Sofia Lövestam,Jenny Shi et al.
Chao Qi et al.
Mutations in MAPT, the tau gene, give rise to forms of frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17 T), with abundant filamentous tau inclusions in brain cells. Some mutations that encode missense and deletion v...
Courtney L Smith,John L Robinson,Edward B Lee
Courtney L Smith
Annexin A11 (ANXA11) is a Ca2⁺-dependent phospholipid-binding protein that has recently emerged as a key player in neurodegeneration. Rare pathogenic ANXA11 variants were initially identified in cases of amyotrophic lateral sclerosis (ALS)...
CTE-type tau filaments in Alzheimer's disease with co-morbid LATE-NC [0.03%]
伴有LATE的阿尔茨海默病中的CTE型tau原纤维
Jaimin K Rana,Emile S Pinarbasi,Martin G Fernandez et al.
Jaimin K Rana et al.
Mutation-specific neuropathologic signatures in MAPT-associated frontotemporal lobar degeneration [0.03%]
MAPT相关tauopathy的突变特异性神经病理标志
Marika Bogdani,Vaishnavi S Jadhav,Brian C Kraemer et al.
Marika Bogdani et al.
Autosomal-dominant frontotemporal lobar degeneration with tau pathology (FTLD-tau) is caused by pathogenic variants in the MAPT gene. Although abnormal tau aggregation is a shared endpoint, MAPT mutations produce distinct cellular phenotype...
Molecular changes during AT/RT progression associated with epithelial-mesenchymal transition and extracellular matrix changes [0.03%]
与上皮间质转化和细胞外基质变化相关的AT/RT进展过程中的分子改变
Lea Altendorf,Anton Althammer,Rajanya Roy et al.
Lea Altendorf et al.
Atypical teratoid/rhabdoid tumors (AT/RT) are the most common malignant brain tumors during infancy and associated with a dismal prognosis. The majority of patients suffer from tumor progression or recurrence, but underlying mechanisms rema...