Future directions in the treatment of brain metastases: evaluating the role of cellular players in the tumour microenvironment [0.03%]
脑转移治疗的未来方向：评估肿瘤微环境中细胞的作用
Chris W Govaerts,J Marc C van Dijk,Anouk van der Hoorn et al.
Chris W Govaerts et al.
Recent clinical trials have demonstrated the efficacy of different modalities of systemic therapy in treating brain metastases, including immune checkpoint inhibitors and various types of targeted therapy. These findings expand treatment op...
Frequency of mixed neuropathologies in individuals with down syndrome with and without Alzheimer's dementia [0.03%]
唐氏综合征伴或不伴有阿尔茨海默病痴呆的混合神经病理特征频率
Lisi Flores-Aguilar,Thomas D Zaikos,Isabel Rivera et al.
Lisi Flores-Aguilar et al.
Individuals with Down syndrome (DS) develop Alzheimer's disease neuropathological change (ADNC) by the age of 40 years, and most develop dementia by their early 50s. The frequency of co-pathologies in clinically and neuropathologically char...
APOE ε4 influences the widespread TDP-43 pathological subtype in sporadic amyotrophic lateral sclerosis [0.03%]
APOE ε4影响散发性肌萎缩侧索硬化中广泛存在的TDP-43病理亚型
Yuya Hatano,Asa Nakahara,Mari Tada et al.
Yuya Hatano et al.
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder, most sporadic cases exhibiting TAR DNA-binding protein 43 (TDP-43) pathology. The anatomical distribution of TDP-43 pathology varies among patients; however, factors...
Molecular signatures and biomarker development for limbic-predominant age-related TDP-43 encephalopathy (LATE) [0.03%]
LPAGD计划的分子标志物和生物标记物开发工作组：变构Tau病和额颞叶痴呆中的TDP-43脑病（LATE）分子标志物和生物标记物研究进展
Ling Wu,Tobilola Akingbade,Peter T Nelson et al.
Ling Wu et al.
Limbic-predominant age-related TDP-43 encephalopathy (LATE) is a neurodegenerative disease marked by TDP-43 proteinopathy, affecting approximately one-third of individuals aged 80 and above. LATE neuropathological change (LATE-NC) is charac...
Molecular profiling of alpha-synuclein pathology and seeding activity in Parkinson's disease [0.03%]
帕金森病中α-突触核蛋白病理和促聚集活性的分子特征分析
Zeynep Bengisu Kaya,Danilyn Amerna,Ananya Susarla et al.
Zeynep Bengisu Kaya et al.
Parkinson's disease (PD) is neuropathologically characterized by the abnormal accumulation of fibrillar alpha-synuclein (aSyn) within selectively vulnerable neuronal populations. Although this pathological hallmark is shared across individu...
CnQuant: high-resolution chromosomal copy number profiling for precision oncology in the clinics [0.03%]
CnQuant：临床精准肿瘤学的高分辨率染色体拷贝数谱分析方法
Benjamin Maciej Freyter,Claus Hultschig,Jon Brugger et al.
Benjamin Maciej Freyter et al.
Lipofuscin accumulation in aging and CLN1 is associated with deficient de-S-acylation, lyso-mitochondrial dysfunction, and lipid dyshomeostasis [0.03%]
脂褐质积累与CLN1缺陷相关的去棕榈酰化、溶酶体线粒体功能障碍和脂质稳态失调
Sofia Massaro Tieze,Alexander Esqueda,Rachel McAllister et al.
Sofia Massaro Tieze et al.
Lipofuscin is an autofluorescent material that accrues in brain tissues with age and in Neuronal Ceroid Lipofuscinosis (NCL), a neurodegenerative disease with pediatric onset. The distribution, composition, and organellar origin of lipofusc...
Idiotypic-susceptible Alzheimer's disease: a clinically relevant, neurofibrillary tangle subtype [0.03%]
idiotypic-易感的阿尔茨海默病：一种具有临床意义的神经原纤维缠结亚型
John L Robinson,Helen Cai,Nicholas J Loh et al.
John L Robinson et al.
Neurofibrillary tangles in Alzheimer's disease (AD) stereotypically spread from the medial temporal lobe to association areas and then to idiotypic areas (i.e., primary motor, somatosensory, auditory, and visual). Previous studies have repo...
Pathogenic IgG from long COVID patients with neurological sequelae triggers sensitive but not cognitive impairments upon transfer into mice [0.03%]
患有神经后遗症的长新冠患者的致病性IgG触发敏感但不会导致认知障碍转移至小鼠体内
Margaux Mignolet,Catherine Deroux,Thomas Florkin et al.
Margaux Mignolet et al.
Approximately 30% of long COVID patients still experience neurological symptoms (brain fog, pain, chronic fatigue) more than 4 months after the onset of COVID-19. This condition, known as 'neurological long COVID', remains poorly understood...
The hypoxia-inflammation cycle as a key mechanism of smoldering inflammation and progression in multiple sclerosis [0.03%]
低氧炎症循环在病灶持续存在的多发性硬化症中的作用机制研究
M Missaglia,M Filippi,F Esposito et al.
M Missaglia et al.
Disease progression in multiple sclerosis (MS) remains a major unmet clinical challenge, as it is driven by pathogenic mechanisms that are poorly targeted by currently available disease-modifying treatments. Whereas acute focal inflammation...