Yasuteru Inoue,Hu Wang,Michael G Heckman et al.
Yasuteru Inoue et al.
Disturbances within the cerebrovascular system substantially contribute to the pathogenesis of age-related cognitive impairment and Alzheimer's disease (AD). Cerebral amyloid angiopathy (CAA) is characterized by the deposition of amyloid-β...
Expansion of the spectrum of tumors diagnosed as myxopapillary ependymomas [0.03%]
被诊断为黏液乳头状室管膜瘤的肿瘤谱系的扩大
Fuat Kaan Aras,Dennis Friedel,Felix Keller et al.
Fuat Kaan Aras et al.
Neuropathological changes in the nucleus basalis of Meynert in people with type 1 or type 2 diabetes mellitus [0.03%]
1型或2型糖尿病患者Meynert黑质核团的神经病理改变
Wei Jiang,Martin J Kalsbeek,Felipe Correa-da-Silva et al.
Wei Jiang et al.
People with type 1 or type 2 diabetes mellitus (T1DM or T2DM) often experience cognitive impairment. We profiled cells in the nucleus basalis of Meynert (NBM) in postmortem human brain tissue to investigate the neuropathological changes. Si...
Reversible tau hyperphosphorylation in hibernation: a blood biomarker and brain tissue study [0.03%]
冬眠中的tau过度磷酸化的可逆性：一项血液生物标志物和脑组织研究
Wagner S Brum,Laia Montoliu-Gaya,Gunnar Brinkmalm et al.
Wagner S Brum et al.
Tau hyperphosphorylation, a key neuropathological feature of tauopathies such as Alzheimer's disease (AD), also occurs physiologically during mammalian hibernation and is fully reversed upon arousal, offering a unique translational model to...
In silico purification improves DNA methylation-based classification rates of pediatric low-grade gliomas [0.03%]
基于DNA甲基化的儿科低级别胶质瘤分类率的改善通过模拟纯化实现
Liv Jürgensen,Salvatore Benfatto,Simone Schmid et al.
Liv Jürgensen et al.
DNA methylation-based classification using the Heidelberg Classifier is a state-of-the-art data-driven method for molecular diagnosis of central nervous system (CNS) tumors. However, many pediatric low-grade glioma (pLGG) samples fail to yi...
Alpha synuclein-mediated cytoskeletal dysfunction impairs myelination in human oligodendrocytes [0.03%]
α-突触核蛋白介导的细胞骨架功能障碍损害人类少突胶质细胞的髓鞘化
Jeanette Wihan,Kristina Battis,Alana Hoffmann et al.
Jeanette Wihan et al.
Oligodendroglial alpha-synuclein (aSyn) deposits are a key feature in the atypical parkinsonian disorder, multiple system atrophy (MSA) linked to profound myelin loss and neurodegeneration while precise cellular and molecular mechanisms rem...
Genetic and clinical characteristics of cranial nerve schwannoma harboring SH3PXD2A-HTRA1 fusion gene [0.03%]
SH3PXD2A-HTRA1基因融合阳性颅神经施万细胞瘤的临床和遗传特征分析
Junki Sogano,Ryota Tamura,Masahiro Yo et al.
Junki Sogano et al.
The SH3PXD2A-HTRA1 fusion gene has recently been identified in a subset of schwannomas, but its frequency and clinical significance remain unclear. This study aimed to investigate the prevalence and clinical relevance of this fusion gene in...
Complement profiling of sural nerves in chronic-inflammatory demyelinating polyneuropathy [0.03%]
慢性炎症性脱髓鞘多发性神经病的腓肠神经补体谱分析
Frauke Stascheit,Andreas Roos,Christina B Schroeter et al.
Frauke Stascheit et al.
Chronic-inflammatory demyelinating polyneuropathy (CIDP) is a rare immune-mediated polyneuropathy causing substantial disability. While both cell-mediated and humoral mechanisms contribute to CIDP, the role of complement remains poorly unde...
Limbic Alzheimer's co-pathology in multiple system atrophy is associated with cognitive impairment and diagnostic inaccuracy [0.03%]
路易体痴呆共病病理与多系统萎缩的认知障碍及诊断不准确相关性研究
Janna van Wetering,Natasja A C Deshayes,Joëlle Boone et al.
Janna van Wetering et al.
The clinical heterogeneity of multiple system atrophy (MSA) may, along with the primary aggregation of alpha-synuclein (α-syn), partly be shaped by co-pathologies, such as amyloid-beta (Aβ), phosphorylated (p)-tau, and pTDP-43, though the...
Spatial transcriptomic analysis reveals lack of response to PD-1 blockade in recurrent glioblastoma [0.03%]
空间转录组分析揭示了复发性胶质母细胞瘤对PD-1阻断缺乏反应
Sara Blaabjerg Artzi,Marc Nihøj Klausen,Dylan Scott Lykke Harwood et al.
Sara Blaabjerg Artzi et al.
Immune checkpoint inhibitors have transformed treatment for several cancers, yet clinical trials of programmed cell death protein 1 (PD-1) blockade in glioblastoma (GBM) have consistently failed to show therapeutic benefit. While some studi...