Intracellular trafficking SNARE protein, syntaxin-6, modifies prion cellular phenotypes and risk of disease development in vivo [0.03%]
胞内运输SNARE蛋白syx6改变细胞型菌斑表型并降低活体小鼠发病风险
Elizabeth Hill,Mitali Patel,Juan M Ribes et al.
Elizabeth Hill et al.
Increased expression of syntaxin-6, a SNARE protein involved in intracellular protein trafficking, is a proposed genetic risk mechanism for sporadic prion disease and progressive supranuclear palsy, as well as being implicated in Alzheimer'...
Spatial protein profiling reveals active roles for astrocytes in the chronic active lesion core during multiple sclerosis [0.03%]
空间蛋白质组学揭示了星形胶质细胞在多发性硬化症慢性活动病灶核心的活性作用
Brandon C Smith,Anthony Chomyk,Maria L Habean et al.
Brandon C Smith et al.
Chronic active lesions are a manifestation of multiple sclerosis (MS) and have been associated with disease progression. While astrocytes are heavily implicated in MS, little is known about their role in lesions, particularly in the lesion ...
Alpha-synuclein deposition patterns in Alzheimer's disease: association with cortical amyloid beta and variable tau load [0.03%]
阿尔茨海默病中的α-突触核蛋白沉积模式与皮层淀粉样蛋白β和可变tau负荷的关联性研究
Antonia Neubauer,Doris Weissenbrunner,Susanna Pekrun et al.
Antonia Neubauer et al.
Alpha-synuclein (α-syn) deposits are common in around half of the Alzheimer's disease (AD) cases. While direct and indirect protein interactions are suggested, the relationships between different protein aggregates remain poorly understood...
Brain-derived 5-hydroxymethylcytosine epigenetic scores are related to Alzheimer's disease pathology and cognitive decline [0.03%]
大脑源性5-羟甲基胞嘧啶表观遗传学评分与阿尔茨海默病病理和认知衰退有关
Zhou Zhang,Ana W Capuano,Alana Beadell et al.
Zhou Zhang et al.
Background: Cytosine modifications play critical roles in gene regulation and disease pathogenesis. Elucidating novel epigenetic contributions to Alzheimer's disease (AD) could advance diagnostic, prognostic, and therapeu...
LRRK2 kinase-mediated accumulation of lysosome-associated phospho-Rabs in tauopathies and synucleinopathies [0.03%]
LRRK2激酶介导的tau病和α-突触核蛋白病中溶酶体相关磷酸化Rab的积累
Silas A Buck,Tuyana Malankhanova,Samuel Strader et al.
Silas A Buck et al.
Parkinson's disease (PD) pathogenic mutations in leucine-rich repeat kinase 2 (LRRK2) are associated with endolysosomal dysfunction across cell types, and carriers of LRRK2 mutations variably present with phosphorylated tau and α-synuclein...
Genetic and proteomic analysis identifies BAG3 as an amyloid-responsive regulator of neuronal proteostasis [0.03%]
基因和蛋白质基因组分析鉴定出BAG3是调控神经元蛋白稳态的淀粉样蛋白反应调节因子
Zachary M Augur,Garrett M Fogo,Mason R Arbery et al.
Zachary M Augur et al.
The autophagy-lysosome pathway (ALP) and the ubiquitin-proteasome system (UPS) are the primary protein degradative mechanisms maintaining proteostasis in neurons. However, the impact of human genetic variation on these pathways and the role...
Molecular characterization and clinical features of diffuse midline glioma in the pediatric precision oncology registry INFORM [0.03%]
儿童精确诊断肿瘤注册表(INFORM)中弥散性中线胶质瘤的分子特征和临床特点
Elke Pfaff,Kathrin Schramm,Mirjam Blattner-Johnson et al.
Elke Pfaff et al.
Diffuse midline glioma (DMG; a subtype of pediatric high-grade glioma) is a fatal disease in children, due to the localization in critical structures of the central nervous system, its invasive nature, and limited treatment options. Molecul...
Timothy E Richardson,Jamie M Walker,Kurt Farrell et al.
Timothy E Richardson et al.
Primary age-related tauopathy (PART) was proposed in 2014 as a neuropathological term to describe patients with Alzheimer's-type medial temporal lobe neurofibrillary degeneration in the absence of significant β-amyloid pathology. Over the ...
Tumor-associated macrophages in meningiomas: a novel biomarker for poor survival outperforming the benefits of T cells [0.03%]
脑膜瘤中的肿瘤相关巨噬细胞：一项优于T细胞益处的新型预后生物标志物研究
Catharina Lotsch,Rolf Warta,Fang Liu et al.
Catharina Lotsch et al.
Tumor-associated macrophages (TAMs) represent the main immune cell population in various brain malignancies, but there is rare knowledge on the functional and, in particular, the prognostic role of TAMs in the meningioma (MGM) microenvironm...
Evolution of pilocytic astrocytoma to diffuse leptomeningeal glioneuronal tumor (DLGNT): bridging two distinct tumor types [0.03%]
毛细胞星形细胞瘤向弥漫性脑室膜胶质神经元肿瘤(DLGNT)的演变：两种不同类型肿瘤之间的桥梁
Daniel C Moreira,Soniya N Pinto,Margit K Mikkelsen et al.
Daniel C Moreira et al.